Product Spec Sheet for Proliposome formulation manufactured by Encapsula NanoSciences that is used specifically in the cosmetic industry. The brand name is Cosmesome-Chol. The Cosmesome-Chol formulation is composed of saturated phospholipids and it does contain alcohol. The proliposome formulation forms liposomes upon dilution with water. During the dilution process water soluble active ingredients can be encapsulated inside the liposomes or liposoluble active ingredients can be incorporated into the lipid bilayers. The formulation is packaged under sterile conditions inside spout pouches.

1. COSMESOMETM
–Chol
CHARACTERISTICS
CosmesomeTM –Chol is a highly concentrated lipid
formulation for cosmetic industry that forms nano-sized
liposomes upon dilution of the formulation
with water using standard mixing devices.
CosmesomeTM –Chol is composed of high purity
saturated soy phospholipids and vitamin A, vitamin E,
and lipid soluble form of vitamin C that form
liposomes with high encapsulation and incorporation
efficiency. The formulation is colorless and
odorless.
CosmesomeTM -Chol is composed of proprietary
blend of phospholipids, vitamin A, vitamin E, and
lipid soluble form of vitamin C in the form of
interdigitated lipids.
Hydration of these lipids with water causes
rearrangement of the lipid bilayers which
spontaneously forms liposomes. If water- soluble
active ingredients, such as peptides, minerals or
other water soluble molecules, are dissolved in water
and added to CosmesomeTM –Chol, liposomes with
high entrapment of the active molecule is formed. If
lipid soluble molecules such as lipid soluble
molecules or antioxidants are added to
CosmesomeTM -Chol and hydrated with water, the
lipid soluble molecule will be incorporated into the
lipid bilayers of the liposomes. Up to 65% of a water
soluble molecule in the solution is encapsulated
inside the liposomes and almost 100% of lipid soluble
molecules is incorporated into the lipid bilayers of
the liposomes.
Since the lipids that are used in the formulation are
saturated, the formulation has to be heated to above
65°C after hydration for at least 20 minutes.
INCI NAME
WATER (and) ALCOHOL (and) HYDROGENATED
LECITHIN (and) CHOLESTEROL
QUICK FACTS
CosmesomeTM products are made
from saturated phospholipids and
are used in processes that require
heating above 65oC. Before using
CosmesomeTM products make sure
that your active ingredient is stable
during processing. The formulation
is alcohol free.
If the active ingredient is
temperature sensitive use the
DermasomeTM product line.
6 Cadillac Dr, Suite 245
Brentwood, TN 37027
United States of America
1-(800) 387-0620
info@encapsula.com
/company/encapsula-nanosciences-
llc
DISCLAIMER
.
Any formulation suggestions or
technical information is based on our
knowledge on the basis of current
scientific data and publications.
Encapsula is only a raw ingredient
manufacturer and cannot accept any
liabilities for products manufactured
by others. Every manufacturer and
formulator is responsible for
compliance with all statutory
regulations including those in the field
of patent legislation.

2. COMPOSITION
Phospholipid 20%
and Cholesterol
Hydrophilic medium 80%
ANALYTICAL DATA
Peroxide value Max. 5
PH (pur) 5-7
MICROBIOLOGICAL DATA
Yeasts/g absence
Molds/g absence
S. aureus / C. albicans absence
and P. aeruginosa/g
PHYSIO-CHIMICAL PROPERTIES
Appearance: Amber liquid
Miscibility Form liposomes spontaneously when
heated to above 65 C after the
addition of water.
STORAGE CONDITION
Stable for 24 months in its original closed packaging
below 8℃ (preferred to be kept in refrigerator).
Reclose container immediately after use and protect
from direct sunlight. If container is opened, keep
container in refrigerator at 4℃ and use within 3
months.
REGULATORY STATUS
No specific regulation
Contains 20% ethanol
PACKAGING
2 oz, 18 oz, 1 Gallon
COSMESOMETM
–Chol
QUICK FACTS
DISCLAIMER
Any formulation suggestions or
technical information is based on our
knowledge on the basis of current
scientific data and publications.
Encapsula is only a raw ingredient
manufacturer and cannot accept any
liabilities for products manufactured
by others. Every manufacturer and
formulator is responsible for
compliance with all statutory
regulations including those in the field
of patent legislation.
.
CosmesomeTM products are made
from saturated phospholipids and
are used in processes that require
heating above 65oC. Before using
CosmesomeTM products make sure
that your active ingredient is stable
during processing. The formulation
is alcohol free.
If the active ingredient is
temperature sensitive use the
DermasomeTM product line.
6 Cadillac Dr, Suite 245
Brentwood, TN 37027
United States of America
1-(800) 387-0620
info@encapsula.com
/company/encapsula-nanosciences-
llc