2006: Artificial Immune Systems - The Past, The Present, And The Future?
1. Artificial Immune Systems: The Past, the Present. And the Future? Leandro Nunes de Castro Catholic University of Santos [email_address] , Support: CNPq, FAPESP ICARIS 2006, Institute Gulbenkian, Portugal
37. Immune Engineering Framework Perform the dynamics and metadynamics of the system: how the immune cells and molecules are going to interact with each other and the antigens, and their survival Immune network Generation of a set of nonself detectors for anomaly detection Negative selection Perform the dynamics of the system: how the immune cells and molecules are going to interact with antigens Clonal selection Promote learning (adaptation) through somatic hypermutation and natural selection Affinity maturation Introduction and/or maintenance of population diversity and/or variation Somatic hypermutation Quantify affinities (match Ab-Ag; Ab-Ab) Affinity function Generation of cellular and molecular repertoires Bone-marrow models Usual Role Mechanism/Principle
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46. Part II AIS: The Present Features, Difficulties and Current Investigations