1. K.Lykostratis Fn
Shear Stress response L
Shear Stress
Calcium Fn
channel Fn
L
PIP2 PLC G Ra R
Fn
+ qin TalinIn Talin Talin Talin
+/- t
Calpain Paxillin
Calpain TalinIn Ta
t Talin lin
degradation a
Paxillin
*
a
Na+ -Ca+ DAG Pa
exchanger TalinCl xilli FA
n K i
v
Calpain Calpastatin FAKi
IP3 RPTP i
Talin
Cac PKC-Ca- a RPTP
qex GRB2
Paxillin
a
Fn
PKCa Calpain PIPKIγ661 Paxillin
PKC-Ca
* Paxillin*
PKCbas
FAKi
Calpastatin
a Talin FAKi
GRB2
+ PKCi *
RPTP PIPKIγ661 PIPKIγ661 FAK
R
aP *
Talin
qcc
Cas IKKi
Paxillin*
Capacitative IKKi PKCa
Fn
calcium entry *
SRCi-p SRC SRC FAK
Ca2+ qres - ER
-ATPase
IKKa
PTP_3 Paxillin*
Talin
PTP_P
Paxillin
CSK
EST *
FAK
*
LEGEND
Ik NF-kB NF-kB
Fn
= Affinity
FAK
= Catalysis
*
= Nuclear ERKp
= Enzyme ERKpp
PTP_PE
nucleus
ST
= GTPase GEF NF-kB
Talin
IkBαt ERK
Paxillin
= GTPase
*
IkBβt
= Adaptor Ik NF-kB PTP_2
IkBεt C-fos
Fn
ES _P FAK
= Phosphatase C-jun
T
P
*
PT
= Kinase
Ik
= TF MEKpp
B Ik Ik Ik MEK Paxillin**
B B B
MEKp
RasG
Paxillin*
Talin
TPp
GRB2
SOS
Paxillin
RasG * SRC
*
FAK
FAK
TPp RasG
PTP_PE **
**
Fn
FAK
TP FAK
Fn
Paxillin
ST
SRC
**
*
RAF RAFp
Talin
RasG
DP RasG
TP
* *
SRC SRC
Talin
RasG
GRB2
SOS
DP
RAF
PTP_1
Paxillin*
FAK
PTP_SR
*
Fn
*
**
C FAK SRC
Fn
Paxillin
**
Talin
SOS
SOS
DOCK1 Paxillin**
GRB2
CRK ** Talin Fn
FAK
GRB2
SOS
FAK
**
Fn
Paxillin
**
DOCK1
CAS
Talin
CRK
Talin
Paxill
*
GR
in FAK
B2
Pa
FA xil
*
K ** ** li n DOCK1 DOCK1 DOCK1
Fn
DOCK1
Ta CRK CRK CRK
li CRK CRK CRK n
n CRK CAS Paxillin Paxillin Pax*illi
Paxillin Paxillin CAS* Paxillin CAS* Paxillin CAS* Paxillin CAS* Paxillin *
SRC Talin
** **
**
** CAS Paxillin ** ** **
**
** Talin Talin ** Talin *
** Talin ** Talin **
** Talin ** Talin ** Talin ** Talin FAK FAK FAK
FAK FAK FAK FAK FAK FAK
FAK
** Talin
Fn
Fn Fn Fn Fn Fn Fn
Fn Fn Fn Fn
Fn
1