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Organic Compounds
Enzymes & Digestion



 Honors Biology ~ Edgar
Figure 4.1
Figure 4.2
             EXPERIMENT
                                                  “Atmosphere”
                                            CH4
                      Water vapor
                                                      Electrode
                                          NH
                                             3 H2


                                                    Condenser


                          Cooled “rain”
                          containing                      Cold
                          organic                         water
                          molecules




                      H2O
                      “sea”


                   Sample for chemical analysis
Figure 4.7
             (a) Structural isomers




             (b) Cis-trans isomers




               cis isomer: The two Xs         trans isomer: The two Xs
               are on the same side.          are on opposite sides.


             (c) Enantiomers

                               CO2H                  CO2H




                        H               NH2   NH2              H
                             CH3                        CH3
                            L isomer                D isomer
Figure 4.8




                                Effective    Ineffective
        Drug    Condition
                               Enantiomer    Enantiomer



    Ibuprofen        Pain;
                inflammation
                               S-Ibuprofen   R-Ibuprofen



    Albuterol     Asthma

                               R-Albuterol   S-Albuterol
Figure 4.UN02




                Estradiol
                            Testosterone
Carbonyl
Hydroxyl
Carboxyl
Amino
Phosphate
Methyl
Sulfhydryl
Hemoglobin JMOL
Monomers and Polymers
Cooperative Binding
Carbonic Anhydrase

• 104 to 106 reactions per second.
Hemoglobin JMOL
Functions of Proteins

 When in doubt…..proteins
Storage
Structural
Transport
Hormonal
Receptor
Contractile & Motor
Defensive
Enzymes
Restriction Enzyme
Enzymes
Enzyme Simulation
• How is the velocity of an enzyme reaction
  effected by:
  – pH
  – Temperature
  – Substrate Concentration
Initial Velocity (V0 or VI)
Initial Velocity (V0 or VI)
Vmax
Enzymatic Pathway
Protein Quantification
Starch
   Starch




                    Glucose




Monomers vs. polymers
AMYLASE:
AMY Gene (multiple copies)




      LACTASE:
      LCT (Single Mutation)
Animal Digestion
Intracellular Digestion
Extracelluar Digestion
2 types of enzymes: Lumen and Brush Boarder
The Fate of Fat
Lipase
Atherosclerosis
Fats – inhibit
      Peristalsis and acid
      secretion




    Release of
    Sodium
    Bicarbonate

Amino acids/Fatty Acids
– enzymes from
pancreas and bile

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Notes de l'éditeur

  1. Figure 4.1 What properties make carbon the basis of all life?
  2. Figure 4.2 INQUIRY: Can organic molecules form under conditions believed to simulate those on the early Earth?
  3. Figure 4.7 Three types of isomers, compounds with the same molecular formula but different structures.
  4. Figure 4.8 The pharmacological importance of enantiomers.
  5. Figure 4.UN02
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