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GBM:
GLIOBLASTOMA
MULTIFORME
DR. HARNARAYAN SINGH
WWW.NEUROSURGERYPRO.COM
WHO Grade IV
brain tumour
Commonest malignant brain
tumour
Extremely rapid growth
Poor survival
Causes of GBM
• No definite cause of GBM
known till date
• History of previous
Radiotherapy is one probable
cause
Symptoms
• Worsening headaches
• Weakness in arm or leg
• Increased sleepiness
• Seizures
• Recurrent vomiting
Diagnosis
MRI of brain with contrast
CT scan
Definitive diagnosis with
Biopsy
Treatment
• Surgery- Craniotomy for maximal safe resection of
tumour
• Radiotherapy- Prevents and delays recurrence
• Chemotherapy in form of oral Temozolamide
Prognosis
• Prognosis is not good
• Survival beyond the first year is seen in less than
50% of patients after diagnosis.
Thank you

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