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The MRF Genome Library: Epidemiology of meningococcal disease-causing lineages in England and Wales from 2010/11 to 2011/12
1. The MRF
Meningococcus Genome Library
www.meningitis.org/research/genome
Dorothea Hill
University of Oxford
MRF conference 2013
Wednesday 6th November
2. ‘Publicly accessible data requires a stable home and
someone to pay the mortgage.’ Dr. Francine Berman, Research Data Alliance
Funding
MRU: Isolates
Illumina genome
sequencing
BIGS database
http://pubmlst.org
3. Whole-genome population structure with ‘Genome Comparator’:
two CC269 (lineage 2) sub-lineages.
lineage 2.2
261 loci
Incl. ST-275, ST-1161
lineage 2.1
Incl. ST-269, ST-467, ST-283
451 loci
lineage 5 (CC32)
100 loci
4. Community improvement of the MRF Genome Library.
dorothea.hill@zoo.ox.ac.uk
Jolley, K. and M. Maiden, Automated extraction of typing information for bacterial pathogens
from whole genome sequence data: Neisseria meningitidis as an exemplar. Euro Surveill, 2013.
5. Meningococcal Reference Unit:
Ray Borrow, Jay Lucidarme, Steve Gray
Pathogen genomics:
Julian Parkhill, David Harris
Maiden Group:
Martin Maiden, Keith Jolley, James Bray