British ophthalmologist, Consultant in Birmingham and Midland Eye Hospital, Born 1852, Newton Abbot; died 1913.
Middle East : asia, egipto, pakistan, afganistan, norte de africa. Murphy y col: in their study of 55 patients in the USA, found that men and women were equally affected
HLA-B5 : Behcet estomatitis aftosa (úlceras o llagas en la boca), úlceras genitales y uveítis DR1 is associated seronegative [3] - rheumatoid arthritis [ Dr4 LES AR.
De los shunts para ser específicos. Murphy et al. 3 documented posterior vitreous detachment (PVD) in 27% of their patients with Eales disease. All these patients with PVD except one, experienced vitreous hemorrhage. Four of these patients had macular holes. The age range of the patients with PVD was from 13 to 63 years, with a mean age of 35 years. The PVD in the younger patients could have been due to a low-grade, chronic inflammation of the vitreous. The macular holes may represent a complication of posterior vitreous separation from the retina secondary to premature vitreous degeneration.Anteroposterior contraction of fibrovascular tissue adherent to both retina and posterior vitreous can cause both traction and rhegmatogenous retinal detachments, though the former are much more common Arteriolar y venular pueden estar afectados.
Disminución significativa de la visión. Secundaria a las multiples hemorragias.
Uveitis es muy rara en etapas tardías de la enfermedad. SP= segmento posterior: Envainamiento vascular =sheating.se envainan tanto los vass que pueden llegar a ocluirse. Hemorragias n flama se encuentran alrededor de los vasos envainados. A mild vitreous haze overlying the areas of vasculitis is more common
Cystoid macular edema can occur in patients with Eales disease due to increased capillary permeability, and inflamation. This can often be associated with significant vision loss. Beading: rectificar al parecer eso significa. Rubeosis que te puede llevar a GNV.
Patients with Eales disease can also develop BVO, which can be either solitary or multiple. These patients can be differentiated from patients with primary BVO because the pathologic changes in BVO are usually confined to the affected quadrant of the retina. In contrast, Eales disease affects more extensive areas of the peripheral retina and does not respect either the anatomic distribution of venules in the retina or the horizontal midline. These two conditions can occur together, and Eales disease may predispose to the development of BVO The NVE is usually located at the junction between perfused and nonperfused retina
The cause of Eales disease is unknown. Eales disease is a diagnosis of exclusion and is thought to be idiopathic. No causative drugs, environmental factors, or infectious agents for Eales disease have been identified. Although a hypersensitivity to tuberculin protein has been reported, no clear relationship to tuberculosis has been found. An 88-kd acute phase reactant protein has been found in patients with Eales disease that is immunologically identical to that found in patients with posterior uveitis, tuberculosis, leprosy, and rheumatoid arthritis. The role of this protein is yet undetermined.