4. An unknown philosopher stated “The lungs
are the center of the universe and the seat of
the soul”.
The earliest reference for attempts to restore
breathing was about 3150 BC when
Egyptian physicians tried to save drowned
victims by placing a reed in the throat and
blowing into the lungs . The Chinese in 2000
BC described lien ch’i, as a transfer of
inspired air into the “soul” (life): mouth
positive pressure.
5. Hippocrates (460−375 BC) wrote the first
directions for intubation in “Treatise on Air”
by placing a “cannula into the trachea along
the jaw bone so that air can be drawn into
the lungs.”
6. First written idea of assisted ventilation by:
Claudius Galen, a physician, in 128 AD who
followed on this by experimentation by
breathing into a hollow reed placed in the
throats of many different animals, and noted
that their chests expanded.
7. The first recorded attempt of “mechanical” ventilation
was in 1550, attributed to Paracelsus, when he used a
fire bellows as a device connected to a tube inserted
in the patient’s mouth to blow air into the lungs to
assist breathing, an “IPPB”.
8. It was John Mayow, an English physician-
scientist in 1673, who first conceived and built an
external negative pressure ventilator, which consisted
of a unit with a bellows and a bladder to pull and
expel air, suggesting that this mimicked the action of
the inspiratory muscles . While he was also the first
to show the necessity of oxygen for life, preceding
Priestley, he did not name it.
His work remained obscure until 1832.
9. First modern negative pressure ventilator:
John Dalziel (1832)
“tank respirator”: Patient sitting in an air tight box
with head sticking out with manual bellows
Dr. Robert Lewins modified it.
Alfred E. Jones from USA, following a similar design,
patented the first American tank respirator in 1864.
He treated asthma and bronchitis with his device
12. Alexander Graham Bell, the inventor of the
telephone, and not a physician, after the death of his
1-day-old son in 1881 designed a metal vacuum
jacket in 1882, which developed negative pressures
with a separate hand pump to artificially “expand’ the
lungs to save lives. It was a unit made of two rigid
halves with soft linings held to the chest by a strap,
with negative pressure provided by large bellows. He
successfully experimented with healthy volunteers.
13. The first widely used negative pressure ventilator:
The Drinker Respirator (aka Emerson Iron Lung)
Designed by Philip Drinker and Louis Agassiz Shaw Jr.
(1928), Powered by an electric motor and 2 air pumps
from a vacuum cleaner.
The first clinical use of the Drinker respirator on a human
was on October 12, 1928, at the Boston Children's
Hospital. The subject was an eight-year-old girl who was
nearly dead as a result of respiratory failure due to polio.
Her dramatic recovery, within less than a minute of being
placed in the chamber, helped popularize the new device.
17. Rancho Los Amigos Hospital, California (1953)
Iron lung from the 1950s in the Gütersloh Town
Museum
18.
19.
20.
21. In 1959, there were 1,200 people using tank
respirators in the United States, but by 2004 there
were only 39. By 2014, there were only 10 people left
with an iron lung
22. Movement away from negative pressure devices (1960s)
Large, taking up much space, difficult to access patient
No PEEP
Significant leakage leading to patient cooling
“Tank shock” – blood pooling in abdomen and lower
extremities
23. they were used for the first time in Blegdams
Hospital, Copenhagen, Denmark, during a polio
outbreak in 1952.[It proved a success and soon
superseded the iron lung throughout Europe.
are now more common than negative pressure
systems.
Positive
pressure
ventilation
24. In 1980sit was recognized that delivery of
continuous positive airway pressure by close fitting
nasal masks for treatment of obstructive sleep apnea
could also be used to deliver an intermittent positive
pressure
NIPPV
32. Nasal masks (general advantages)
Best suited for more cooperative patients
Better in patients with a lower severity of illness
Not claustrophobic
Allows speaking, drinking, coughing, and secretion clearance
Less aspiration risk with emesis
Generally better tolerated
Nasal masks (cautions, disadvantages)
More leaks possible (eg, mouth-breathing or edentulous
patients)
Effectiveness limited in patients with nasal deformities or
blocked nasal passages
Interfaces
34. Orofacial masks (general advantages)
Best suited for less cooperative patients
Better in patients with a higher severity of illness
Better for patients with mouth-breathing or pursed-lips
breathing
Better in edentulous patients
Generally more effective ventilation
Orofacial masks (cautions, disadvantages)
Claustrophobic
Hinder speaking and coughing
Risk of aspiration with emesis
Interfaces
37. INTERFACE
S
Clinical trials have not demonstrated the
superiority of any interface
Although:
• the nasal mask may be more effective in patients
with a lower severity of illness.
• In patients with a higher severity of illness the
orofacial mask and total face mask appear to result
in comparable outcomes.
38. Coma
Cardiac arrest
Respiratory arrest
Any condition requiring immediate intubation
Cardiac instability
Shock and need for pressor support
Ventricular dysrhythmias
Complicated acute myocardial infarction
GI bleeding - Intractable emesis and/or uncontrollable bleeding
Inability to protect airway
Impaired cough or swallowing
Poor clearance of secretions
Depressed sensorium and lethargy
Status epilepticus
Inability to fix the interface
facial -abnormalities, burns, trauma, anomalies
Potential for upper airway obstruction
Extensive head and neck tumors
Any other tumor with extrinsic airway compression
Angioedema or anaphylaxis causing airway compromise
Non availability of trained medical personnel
CONTRAINDICATIONS
39. Patient cooperation (an essential component that excludes
agitated, belligerent, or comatose patients)
Dyspnea (moderate to severe, but short of respiratory failure)
Tachypnea
Increased work of breathing (accessory muscle use, pursed-lips
breathing)
Hypercapnic respiratory acidosis (pH range 7.10-7.35)
Hypoxemia (PaO 2/FIO 2 < 200 mm Hg, best in rapidly reversible
causes of hypoxemia)
Patient
inclusion
criteria
40. 1. A co-operative patient who can control their airway
and secretions with an adequate cough reflex. The
patient should be able to co-ordinate breathing
with the ventilator and breathe unaided for
several minutes.
2. Hemodynamically stable
Requirements f
or Successful
NIV support
41. Chronic obstructive pulmonary disease
Cardiogenic pulmonary edema
After discontinuation of mechanical ventilation (COPD)
Community-acquired pneumonia (and COPD)
Asthma
Immunocompromised state
Postoperative respiratory distress and respiratory
failure
Do-not-intubate status
Neuromuscular respiratory failure
Decompensated obstructive sleep apnea/cor pulmonale
Cystic fibrosis
Mild Pneumocystic carinii pneumonia
Suitable
Clinical
Conditions
for NIV
43. Controlled mechanical ventilation:
No patient effort
Referred as Timed (T) mode
Similar to PCV
Assist mode:
Ventilatory support to patients effort. No backup
Referred to spont. (S) mode
Similar to PSV
Assist control ventilation:
Ventilatory support in response to pt. effort and backup safety
rate if pt. does not trigger
Referred as spontaneous/timed (S/T) mode
Similar to PS with apnea backup with PC breaths
Modes of
ventilation
44. CPAP:
A constant pressure is applied to airway throughout the cycle
Used primarily to correct hypoxemia
Not a ventilatory mode
Main indication- cardiogenic pulmonary edema, OSA, …
Modes of
ventilation
45. Proportional Assist Ventilation (PAV)
By instantaneously tracking patient inspiratory flow
and its integral (volume) using an in-line
pneumotochograph, this mode has the capability of
responding rapidly to the patient’s ventilatory effort.
By adjusting the gain on the flow and volume signals,
one can select the proportion of breathing work that is
to be assisted.
Modes of
ventilation
46. Other Modes of Noninvasive Ventilatory
Assistance
Modes of
ventilation
47. Most patients who are provided noninvasive
ventilation are provided support with pressure
ventilation, with continuous positive airway
pressure (CPAP), which is the most basic level of
support.
CPAP may be especially useful in patients with
congestive heart failure or obstructive sleep apnea
Modes of
ventilation
49. Bilevel positive airway pressure (BiPAP) is
probably the most common mode noninvasive
positive pressure ventilation and requires
provisions for inspiratory positive airway pressure
(IPAP) and expiratory positive airway pressure
(EPAP).
The difference between IPAP and EPAP is a
reflection of the amount of pressure support
ventilation provided to the patient, and EPAP is
synonymous with positive end-expiratory pressure
(PEEP).
Modes of
ventilation
50. Bi-PAP and
Changes in
EPAP Pressure
5 cm
Delta P 10 cm
10 cm
15 cm
Delta pressure 5
cm
EPAP increased to 10 cm
IPAP increased to 20 cm
Delta P returned to 10 cm
P
R
E
S
S
U
R
E
Decreasing delta pressure will usually result in lower Vt
51. recognize that certain parameters may predict successful
noninvasive ventilation or failure of noninvasive ventilation.
reflection of the patient's ability to cooperate with noninvasive
ventilation,
patient-ventilatory synchrony,
noninvasive ventilation effectiveness
Trials of noninvasive ventilation are usually 1-2
hours in length and are useful to determine if a
patient can be treated with noninvasive ventilation.
Extended trials without significant improvement are not
recommended because this only delays intubation and mechanical
ventilation
Predictors of
successful
noninvasive
ventilation
52. Predictors of success - Response to trial of NIV (1-2 h)
Decrease in PaCO2 greater than 8 mm Hg
Improvement in pH greater than 0.06
Correction of respiratory acidosis
Predictors of
successful
noninvasive
ventilation
53. failure to NIV
No improvement in gas exchange or dyspnea
progressively increases
Deterioration or no change in the mental condition of
the hypercapnic patients
Need for airway protection
Hemodynamic instability
Fresh MI or arrhythmias
Patient unable to tolerate the mask
When to
intubate
during
NIV???
54. Facial and nasal pressure injury and sores
Result of tight mask seals used to attain adequate inspiratory volumes
Minimize pressure by intermittent application of noninvasive ventilation
Schedule breaks (30-90 min) to minimize effects of mask pressure
Balance strap tension to minimize mask leaks without excessive mask
pressures
Cover vulnerable areas (erythematous points of contact) with protective
dressings
Gastric distension
Rarely a problem
Avoid by limiting peak inspiratory pressures to less than 25 cm water
Nasogastric tubes can be placed but can worsen leaks from the mask
Nasogastric tube also bypasses the lower esophageal sphincter and permits
reflux
Dry mucous membranes and thick secretions
Seen in patients with extended use of noninvasive ventilation
Provide humidification for noninvasive ventilation devices
Provide daily oral care
Aspiration of gastric contents
Especially if emesis during noninvasive ventilation
Avoid noninvasive ventilation in patient with ongoing emesis or hematemesis
Complications
of Noninvasive
Ventilation
55. Complications of both noninvasive and invasive ventilation
Barotrauma (significantly less risk with noninvasive
ventilation)
Hypotension related to positive intrathoracic pressure
(support with fluids)
Complications
of Noninvasive
Ventilation
56. Complications Avoided by Noninvasive Ventilation
Ventilator-associated pneumonia
Sinusitis
Reduction in need for sedative agents - Sedatives used in less
than 15% of noninvasive ventilation patients in one survey
Complications
Avoided by
Noninvasive
Ventilation
57.
58. BIPHASIC CUIRASS
VENTILATION
BCV is a modern development of the iron
lung, consisting of a wearable rigid upper-
body shell (a cuirass) which functions as a
negative pressure ventilator.
The ventilation is biphasic because the
cuirass is attached to a pump which
actively controls both the inspiratory and
expiratory phases of the respiratory cycle.
This method is a modern improvement of
'negative pressure ventilation' (NPV),
which could only control inspiratory
breathing, relying on passive recoil for
exhalation.
BCV was developed by Dr Zamir Hayek, a
pioneer in the field of assisted ventilation.
59.
60. * Patient selection is crucial
1. Appropriately monitored location, oximetry, respiratory impedance, vital signs as clinically indicated
2. Patient in bed or chair at >30 angle
3. Select and fit interface
4. Select ventilator
5. Apply headgear; avoid excessive strap tension (one or two fingers under strap)
6. Connect interface to ventilator tubing and turn on ventilator
7. Start with low pressure in spontaneously triggered mode with backup rate;
(pressure limited: 8 to 12 cm H2O inspiratory pressure; 3 to 5 cm H2O expiratory pressure)
8. Gradually increase inspiratory pressure (10 to 20 cm H2O) as tolerated to achieve alleviation of dyspnea,
decreased respiratory rate, increased tidal volume (if being monitored), and good patient-ventilator synchrony
9. Provide O2 supplementation as need to keep O2 sat >90 percent
10. Check for air leaks, readjust straps as needed
11. Add humidifier as indicated
12. Consider mild sedation (eg, intravenously administered lorazepam 0.5 mg) in agitated patients
13. Encouragement, reassurance, and frequent checks and adjustments as needed
14. Monitor occasional blood gases (within 1 to 2 hours) and then as needed
Protocol for initiation of noninvasive positive pressure ventilation