7. Epicutaneous sensitization leads to systemic immune response Spergel JM et al. J Clin Invest 1998; 101:1614–22 - 땅콩 단백질함유 피부연화제 국소도포 : 땅콩 감작이 증가 - 천식 (+) AD(-) vs 천식 (-) AD(+) : 두군 모두 집먼지진드기에 기도 과민성 , 아세틸콜린에 AD 환아에서 천식범위의 반응 > 피부감작이 기도 감작으로 발전 .
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13. 아토피피부염 발생기전 아토피피부염 유 전 환 경 환경에 대한 비정상적인 Th2 면역반응 염증자극에 대한 피부의 과잉반응 피부 장벽의 기능장애
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15. Genetics Inflammation & desquamation Immune Response (host depense genes) Skin Barrier (epidermal differenciation genes) TEWL(impaired barrier formation) Filaggrin (Loss-of–function mutation) Protein SPINK5 gene (uppermost epidermist) LEKT1 inhition 2 serine protease Imbalance of protease vs protease inhibitor impaired barrier function
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28. Th2 type reactivity before and after birth . Potential pathway of IgE-mediated antigen focusing occurring via interaction of foetal gastrointestinal tract and amniotic fluid. Hypothesis ( 엄마의 특이 IgE + 산모를 통한 항원 노출 ) -> 두 위험요소가 결합하여 아기의 면역을 Th2 로 유지하게 하여 출생 후 아토피 질환에 영향을 미칠 것이다 . Holloway JA. Warner JO. Does atopic disease start in foetal life?. Allergy. 55(1):2-10, 2000
29. Th2 type reactivity before and after birth . ( Bjorksten,1998 ) Primary immune responses to allergens encountered early in life include TH 1- and TH 2-like immunity. ( Bjorksten,1998 ) Allergy Prevention
30. Correa JMM et alii J Pediatr (Rio J) 2001; 77 (6): 441-46 Allergy Prevention X X X
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33. Dietary prevention recommendations /comments from several professional organizations J Allergy Clin Immunol 2008;122:29-33 Allergy Prevention
38. I Pregnancy: physiological T helper type 2 priming; intrauterine allergen exposure. II Neonatal period: the establishment of gut microbiota and neonatal antigen exposure. III Critical windowcounterregulatory mechanisms. IV Early symptoms of allergic disease: V Fully established allergic disease: European journal of gastroenterology & hepatology17(12), December 2005 Allergen free Nutrients
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Notes de l'éditeur
I Pregnancy: physiological T helper type 2 priming; intrauterine allergen exposure. II Neonatal period: neonatal T helper type 2 responses are lower in infants who develop atopic disease compared with those who remain healthy; mode of delivery, the establishment of gut microbiota and neonatal antigen exposure. III Critical window: healthy infants exhibit a decline in T helper type 2 responses during the early postnatal period, whereas a converse pattern is characteristic in infants developing atopic disease; counterregulatory mechanisms. IV Early symptoms of allergic disease: atopic eczema, food allergy; induction of tolerance, control of allergic inflammation. V Fully established allergic disease:
