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Desarrollo embriologico del complejo dentino pulpar. @munevarjuan

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Desarrollo embriologico del complejo dentino pulpar. @munevarjuan

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Desarrollo embriologico del complejo dentino pulpar. @munevarjuan

  1. 1. DESARROLLO EMBRIOLOGICO DEL COMPLEJO DENTINO - PULPAR Presentado por:Presentado a: * Alvarado, Carmen* Dr. Jorge Forero * Arnal, Aylin* Dr. Juan Carlos Munévar * Contreras, Ma. Gabriela
  2. 2. Índice1. Desarrollo Embriológico del complejo Pulpo Dentinal; Estadios de desarrollo.2. Sistemas Experimentales para el Estudio del Desarrollo Dental.3. Interacciones epitelio mesenquima4. Mecanismos celular, fisiología.
  3. 3. Desarrollo embriológico del complejo dentino-pulpar
  4. 4. Pulpa, tejido blando de origen mesenquimatosoOdontoblastos, células especializadas Dispuestas en forma periféricaQue están en contacto con la matriz de la dentinaComplejo dentino pulpar
  5. 5. Desarrollo embrionario Morfogénesis = Desarrollo y formación de los patrones coronarios y radiculares. Histogénesis = Formación de diferentes tejidos dentarios
  6. 6. La papila dental que da origenLa pulpa deriva de a la pulpa madura se desarrolla la cresta neural conforme las Células ectomesenquimatosa Proliferan y se condensan El desarrollo se inicia a partir de la 6ta semana de vida intrauterina El epitelio bucal se forma de dos capas: 1. Capa basal de células epitelialesFormación de dos estructuras en 2. Capa superficial de células forma de herradura = Lamina aplanadas dentaria primaria Lamina vestibular Lamina dental
  7. 7. Estadios del desarrollo embrionario Estadio de brote o yema dentaria: Fase inicial Las células epiteliales de la lámina dental proliferan y producen una proyección en forma de brote En el ectomesénquima adyacente aparecen diez brotes o yemas a la vez en cada maxilar.
  8. 8. Estadios del desarrollo embrionario Estadio de Casquete: Las células de la lámina dental han proliferado Las células externas son cuboides y constituyen el epitelio externo del esmalte Las células internas son alargadas y representan el epitelio interno del esmalte Entre estos dos epitelios existe una red de células, conocida como retículo estrellado El reborde del órgano del esmalte se conoce como asa cervical
  9. 9. Estadios del desarrollo embrionario Estadio de Campana:. Se acentúa la invaginación del epitelio interno Ectomesénquima parcialmente invaginado por el epitelio y vasos sanguíneos ubicados en la papila dental El ectomesénquima condensado que rodea al órgano del esmalte y al complejo de la papila forma el saco dental y el ligamento periodontal
  10. 10. Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  11. 11. INTERACCIONESEPITELIO-MESENQUIMA
  12. 12. Cuatro moléculas de señalización claves en el desarrollo dental. BMP Proteína Morfogenética Ósea FGFs Factor de Crecimiento Fibroblástico Shh Sonic Hedgehog Wnt Son moléculas de señalización
  13. 13. FACTORES DE CRECIMIENTO
  14. 14. BMP2Señal imp. Durante el inicio del desarrollo dental. Induce laexpresión de Msx1,2 y Lef1•Componentes de la osteo-inducción.•Relacionado con la interacción epitelio. mesénquima deldesarrollo del diente y otros órganos• BMP 2,4 y 7 son expresadas en el epitelio dental durantela morfogénesis temprana•BMP2: Inducen expresión de Lef1 en mesénquima
  15. 15. Bmp-2Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  16. 16. Bmp-2Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  17. 17. Bmp-2Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  18. 18. BMP-4Principal componente de señalización capaz de inducir laodontogénesis en el mesénquima.•Bmp4: cromosoma 14. Papila dental, odontoblastos,preodontoblastos. Molares inf.•Inducen la expresión de Msx1 y Msx2.•Determina las posiciones en las cuales se forman losgérmenes dentales y sus características morfológicas.
  19. 19. Bmp-4Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  20. 20. Bmp-4Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  21. 21. Bmp-4Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  22. 22. BMP-7•Induce la proliferación celular y expresión de Msx1 y Msx2•Función similar a la de BMP4•Expresado en epitelio mandibular
  23. 23. Bmp-7Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  24. 24. Bmp-7Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  25. 25. Bmp-7Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  26. 26. FGFEstimulador de la división y proliferación celular en elepitelio y mesénquima. Induce exp. Msx1• Median en el crecimiento y diferenciación de células en eldesarrollo• Expresados en las células epiteliales de desarrollo de losgérmenes dentales cuando las interacciones epiteliomesénquima regulan la morfogénesis odontogénica.•Sólo siete (7) participan en el desarrollo dentario. 3, 7, y10 se expresan en el mesénquima y 4, 8, 9 y 20 lo hacen enel ectodermo
  27. 27. FGF TIPOSFGF4 – FGF 8- FGF9:-Se expresan en el epitelio oral primitivo-En iniciación esta expresión se restringe al epitelio dentaly persiste hasta inicio de brote-FGF4 y FGF8 Se comienza a regular en etapa de casquete ynudo del esmalte-FGF4 y FGF8 Median la iniciación del desarrollo deldiente.-FGF4 y FGF9 Determinan morfología coronal
  28. 28. FGF4Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  29. 29. FGF4Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  30. 30. FGF4Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  31. 31. FACTORES DE TRANSCRIPCION
  32. 32. FACTORES DE TRANSCRIPCION Msx 1 Segmento Muscular home box 1 Segmento Muscular home box 2 Shh Sonic Hedgehog Lef 1 Factor intensificación de células Linfoides Pax 9 Paired box gene
  33. 33. GENES HOMEOBOX
  34. 34. Msx1 y 21 = Cromosoma 5. Molares. Papila dental, odontoblastos,ligamento periodontal.2 = cromosoma 13. Molares inf. Odontoblastos,cementoblastos, ligamento periodontal. Necesario para que BMP4 se exprese en los cambios desde epitelio a mesénquima amplificando la señal de BMP4.
  35. 35. Funciones: Necesario para la iniciación del desarrollo deincisivos. En la señalización de la etapa de brote.-Son expresados donde las interacciones epiteliomesénquima son requeridas.-Formación del nudo del esmalte.-Control de la formación de los procesos palatinos- Alteraciones en este gen produce: Hipodoncia, Paladarhendido
  36. 36. Msx-1Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  37. 37. Msx-1Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  38. 38. Msx-1Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  39. 39. Msx-2Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  40. 40. Msx-2Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  41. 41. Dlx1 Dlx2 Son expresados en mandíbula. Cromosoma 2 locus 2q32, en el msénquima dental. Interviene en el desarrollo óseo. - Requeridos para la formación de molares. - La expresión de otros genes Dlx depende de la pérdida de Dlx1 y 2. - Los ratones transgénicos que carecen de estas no desarrollan molares superioresQuintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  42. 42. Dlx-1 y Dlx-2Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  43. 43. Lef 1Potenciador linfoide vinculante. Cromosoma 3, Locus 4q23-q25. Induce señalización durante el desarrollo junto conWnt en molares inferiores.Factor de transcripción por células linfoides. - Única función en odontogénesis es activar el FGF4 yconectar el Wnt. - Su daño causa mutación en etapa de casquete.
  44. 44. Lef 1Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  45. 45. ShhSe restringe a engrosamientos específicos del epitelio.Papel crucial en la morfogénesis.Formación de cúspides.
  46. 46. SHHQuintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  47. 47. Pax-9Cromosoma 14 locus14q12-q13. Se expresan en mesénquima. Esencial para la morfogénesis Alteraciones para este gen causa oligodoncia severa
  48. 48. Pax-9Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  49. 49. Pax-9Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  50. 50. Explicación Barx-1
  51. 51. Barx-1Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  52. 52. Barx-1Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  53. 53. Explicacion P21
  54. 54. P21Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  55. 55. P21Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  56. 56. Explicacion Pitx-2
  57. 57. Pitx-2Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  58. 58. Pitx-2Quintessence International. “Developmental biology and building a tooth”, Dental research, Irma Thesleff Vol.34, No 8. 2003 pag 613-620
  59. 59. OTROSFACTORES,explicacion
  60. 60. Ectodisplasin
  61. 61. Ectodisplasin
  62. 62. Desarrollo de la raíz
  63. 63.  Después de formarse el esmalte se comienza a formarla raíz Unión de las células del epitelio interno y externo delórgano dental Vaina radicular epitelial de Hertwig determina tamaño,forma y número de raíces Epitelio interno Epitelio Asa órgano externo dental
  64. 64. Proliferación de células epiteliales de la Hendidura de la vaina radicular Induce diferenciación de células mesenquimatosas adyacentes ODONTOBLASTOS Cementoblastos Depositan la matriz del cemento sobre la Dentina radicular
  65. 65. Diferenciación del odontoblasto
  66. 66.  Diferenciación de ameloblastos yodontoblastos = Fase de campana Preodontoblastos se diferencianmas rápido que los odontoblastos Ameloblastos maduros aparecenprimero que los odontoblastos A pesar de esto Matriz de dentina se forma antes que el esmalte.
  67. 67.  Una capa de células (preodontoblastos), se alinean a lo largo de la membrana basal, separando el epitelio interno del esmalte de la papila dental. Las células dejan de dividirse y se alargan formando células cilíndricas con núcleo basal. Los odontoblastos se diferencian y van adoptando forma alargada y características de células secretoras de proteínas.
  68. 68.  La dentinogénesis comienza en los lugares donde seforman las puntas de cúspides y bordes incisales, es aquídonde los odontoblastos alcanzan la madurez completa. Con el comienzo de la dentinogénesis la papila dental seconvierte en la pulpa dental. Formando el complejo dentino-pulpar
  69. 69. SISTEMASEXPERIMENTALES
  70. 70. Modelo transgénicoUn ratón transgénico es un ratón al que se le ha modificado su ADN. Estas modificaciones consisten en la introducción de un gen nuevo.
  71. 71. Modelo Knockout Un “”ratón knock-out”” (KO) es un organismo genéticamente modificado (OGM) el cual carece de la expresión de un gen en particular Son muy útiles en el estudio del cáncer y otras enfermedades complejas.
  72. 72. Microdiseccion de captura laserCorrelación entre loscambios morfológicos y la expresión de losgenes estudiados de la MEC durante la diferenciación de los odontoblastos.
  73. 73. Sistema de cultivo para el órgano dental1. Estudio in vitro para separar epitelio y mesénquima dental.2. Se separa el epitelio y mesenquima dental por medio de enzimas3. Se incuban en un medio rico en proteína BMP y es colocado en el mesénquima4. Se trasplantan in vivo para estudiar efectos en el desarrollo dental

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