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Optic atrophy and neuroretinitis
1. By
Mutahir Shah
Resident M Phil VS
Pakistan Institute of Community
Ophthalmology
Optic Atrophy and Neuroretinitis
2. Optic Atrophy:-
Introduction
Optic atrophy refers to the late stage changes that
take place in the optic nerve resulting from axonal
degeneration in the pathway between the retina and
the lateral geniculate body, manifesting with
disturbance in visual function and in the appearance
of the optic nerve head.
It can be classified in several ways,
including by whether axonal death is initiated in the retina
(anterograde)
or more centrally (retrograde), and by cause.
Optic ‘atrophy’ is not true atrophy, a term that strictly
refers to involutional change secondary to lack of use.
3. Primary Optic Atrophy
Primary optic atrophy
Primary optic atrophy occurs without antecedent
swelling of the optic nerve head.
It may be caused by lesions affecting the visual
pathways at any point from the retrolaminar portion of
the optic nerve to the lateral geniculate body.
Lesions anterior to the optic chiasm result in
unilateral optic atrophy, whereas those involving the
chiasm and optic tract will cause bilateral changes.
4. • Signs
Flat white disc with clearly delineated margins (Fig.
19.7A).
Reduction in the number of small blood vessels on
the disc surface.
Attenuation of peripapillary blood vessels and
thinning of the retinal nerve fibre layer (RNFL).
The atrophy may be diffuse or sectoral depending on
the cause and level of the lesion.
Temporal pallor of the optic nerve head may indicate
atrophy of fibres of the papillomacular bundle, and is
classically seen following demyelinating optic neuritis.
Band atrophy is a similar phenomenon caused by
involvement of the fibres entering the optic disc
nasally and temporally; it occurs in lesions of the optic
chiasm or tract and gives nasal as well as temporal
5. Optic atrophy. (A) Primary due to compression; (B) primary due to nutritional
neuropathy – note predominantly temporal pallor;
6. • Important causes
Optic neuritis.
Compression by tumours and aneurysms.
Hereditary optic neuropathies.
Toxic and nutritional optic neuropathies; these
may give temporal pallor, particularly in
early/milder cases when the papillomacular fibres
are preferentially affected (Fig. 19.7B).
○ Trauma.
7. Secondary optic atrophy
Secondary optic atrophy is preceded by long-standing
swelling of the optic nerve head.
• Signs vary according to the cause and its
course.
Slightly or moderately raised white or greyish disc
with poorly delineated margins due to gliosis (Fig. C).
Obscuration of the lamina cribrosa.
Reduction in the number of small blood vessels on
the disc surface.
Peripapillary circumferential retinochoroidal folds,
especially temporal to the disc (Paton lines –C),
sheathing of arterioles and venous tortuosity may be
8. secondary due to chronic papilloedema – note prominent Paton lines
9. Causes
Include
chronic papilloedema,
anterior ischaemic optic neuropathy
papillitis.
Intraocular inflammatory causes of marked disc
swelling are sometimes considered to cause
secondary rather than consecutive atrophy
10. Consecutive optic atrophy
Consecutive optic atrophy is caused by disease of
the inner retina or its blood supply.
The cause is usually obvious on fundus
examination,
e.g. extensive retinal photocoagulation, retinitis
pigmentosa or prior central retinal artery occlusion.
The disc appears waxy, with reasonably preserved
architecture
consecutive due to vasculitis
11. Neuroretinitis
Neuroretinitis refers to the combination of optic
neuritis and signs of retinal, usually macular,
inflammation.
Cat-scratch fever is responsible for 60% of cases.
About 25% of cases are idiopathic (Leber
idiopathic stellate neuroretinitis).
Other notable causes include syphilis, Lyme
disease, mumps and leptospirosis.
12. Diagnosis
Symptoms.
Painless unilateral visual impairment, usually gradually
worsening over about a week.
Signs
VA is impaired to a variable degree.
Signs of optic nerve dysfunction are usually mild or
absent, as visual loss is largely due to macular
involvement.
Papillitis associated with peripapillary and macular
oedema (Fig. 19.12A).
A macular star (Fig. 19.12B) typically appears as disc
swelling settles; the macular star resolves with a return to
normal or near-normal visual acuity over 6–12 months.
Venous engorgement and splinter haemorrhages may be
present in severe case.
Fellow eye involvement occasionally develops.
14. Investigation and Treatment
Optical coherence tomography (OCT)
demonstrates sub- and intraretinal fluid to a
variable extent.
Fluorescein angiography (FA) shows diffuse
leakage from superficial disc vessels.
Blood tests may include serology for Bartonella
and other causes according to clinical suspicion
Treatment
This is specific to the cause, and often consists of
antibiotics. Recurrent idiopathic cases may
require treatment with steroids and/or other
immunosuppressants.