Pathology is the scientific study of disease. It focuses on the etiology, pathogenesis, morphology, and functional consequences of disease. Pathologists study diseases through various methods including gross and microscopic examination of tissues and cells, immunohistochemistry, cell culture, and molecular techniques. Learning pathology involves understanding both general pathology which examines common disease processes, and systemic pathology which examines organ-specific diseases.

1. Chapter One Introduction to Pathology Section A What is pathology?

12. Pathogenesis Immunologic, cytogenetic and molecular analyses of tissues and cells are increasingly becoming guides to render diagnoses, to assess prognosis, and to suggest therapy.

16. Renal Infarction

19. Normal glomerulus

20. Membranous GN

23. Section B What do pathologists do?

34. Tissue sections are embedded with paraffin.

35. stony hard lump or mass on palpation

37. Diagnosis: Carcinoma of the breast The invasive duct carcinoma usually has an abundant fibrous stroma, so it is also refered to as scirrhous carcinoma. Dense collagenous background

39. Sputum smears of cytology

40. Pap smear of CIN-III Large hyperchromatic nuclei, nuclear pleomorphism .There are some interspersed neutrophils with lobated nuclei and much smaller size.

42. Sample Case:

44. Right neck mass

52. Nude mice

53. Section C How do pathologists do?

57. Renal Infarction

63. Renal Infarction

64. Liver cirrohsis

65. Liver carcinoma

70. Normal glomerulus

71. Membranous GN

72. A masson trichrome preparation shows complete replacement of virtually all glomeruli by blue-staining collagen. Chronic glomerulonephritis:

78. Section D about the subject of Pathology, How to learn pathology?

80. Pathology The Status of Pathology in Medicine a bridging discipline the clinical practice of medicine basic science