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GENETIC CODE
INTRODUCTION ,[object Object]
Genetic code is a Dictionary consists of “Genetic words” called CODONS.,[object Object]
First elucidation of codon was done by Marshall Nirenberg and Heinrich J.Matthaei in 1961.,[object Object]
Similarly another experiment confirmed that poly-adenine RNA sequence specified the amino acid “Lysine” and poly-cystosine sequence coded for amino acid “Proline”.,[object Object]
SALIENT FEATURES OF GENETIC CODE ,[object Object]
Genetic code has “Start and Stop codons”.Startcodon is usually AUG.,[object Object]
Genetic code is continuous and non-overlapping.
Genetic code is Universal.
Genetic code is Degenerate.      >Degeneracy of code is not uniform.       >Degeneracy results because there are         more codons to encode 20 amino          acids.
   >This property of genetic code makes it        more fault-tolerant for “Point mutation” ,[object Object],      “5’ base of anticodon that binds to 3’         base on the mRNA was not spatially        confined as the other 2 bases and        could does have non-standard base       pairing”.
[object Object],    >Genetic code tells how protein sequence information is stored in nucleic acids and how that information is translated into proteins. ,[object Object],    >In certain proteins, non-standard aminoacids are subtituted for standard Stop codon depending on associated signal sequence in mRNA.

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Gentic code

  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. Genetic code is continuous and non-overlapping.
  • 9. Genetic code is Universal.
  • 10. Genetic code is Degenerate. >Degeneracy of code is not uniform. >Degeneracy results because there are more codons to encode 20 amino acids.
  • 11.
  • 12.
  • 13.
  • 14. >For example, UGA can be code for Selenocysteine (now viewed as 21 amino acid) and UAG can code for Pyrrolysine (viewed as 22nd amino acid). >Genetic code is Universal except few mitochondrial codes and, small variants such as translation of the codon UGA as Tryptophan in the species Mycoplasma and translation of CUG as Serine rather than Leucine in the genus Candida.
  • 15. >In Bacteria and Archaea, GUG and UUG are common start codons but in rare cases certain proteins may use alternative start codons not normally used by that species. Conclusion >Despite these differences, all known species codes are very similar to each other and the coding mechanism is the same for all organisms: three base codons, tRNA, ribosomes, reading the code in the same direction and translating the code 3 letters at a time into sequence of amino acids.