Introduction: Occupational stress is reported as the major work-related health problem in Greece, because of the continuing worsening of work climate due to the acceleration of the economic debt crisis and the fiscal problems. Work stress is related to a number of problems and its combination with the growth of job insecurity can easily create conflicts between employers and employees. Purpose: The main purpose of this study is to investigate how Doctors and Nurses working in the Greek private Health sector are influenced by occupational stress and job insecurity, how they react and what consequences are reported considering the quality of delivered services. Design/methodology/approach: A questionnaire consisted of 77 items was used in order to investigate the main factors and the level of occupational stress, burnout, job insecurity, personality type, job involvement and job satisfaction. The participants came up to 130 doctors and 103 nurses and mostly of them are working in private hospitals of Athens and Thessaloniki.