In this webinar, Helena Deus talks about the COVID-19 knowledge graph that Elsevier created by applying text mining techniques on relevant papers. She also discusses why a knowledge graph was used.

1. THE PROTEIN REGULATORY
NETWORKS OF COVID-19

4. THE PROTEIN REGULATORY NETWORKS OF COVID-19
WHAT SCIENTISTS NEED TO WORK ON DURING A PANDEMIC?
1. Drug repurpose / Vaccine repurpose
1. Find FDA approved drugs /medicines (already shown to be safe)
2. Identify which drugs bind to proteins used by the virus
2. Scale up testing
1. Most hospitals use only one testing facility, which can quickly get overwhelmed
2. Carry out antibody tests and contact tracing
3. Reliable information
1. Doctors sharing and trusting information shared on social media faster than preprints
available
2. Policy makers need help understanding the spread in order to control it

5. SCALING UP VACCINES AND TREATMENTS
https://www.av.co/covid
THE PROTEIN REGULATORY NETWORKS OF COVID-19

6. SCALING UP VACCINES AND TREATMENTS
https://www.av.co/covid
THE PROTEIN REGULATORY NETWORKS OF COVID-19

7. DEEP DIVE INTO THE
BIOLOGY OF COVID-19

8. COVID-19 – The name of the disease
Sars-Cov-2 or 2019-nCoV (old) – The virus
itself
Coronavirus – The class of virus that Sars-
Cov-2 belong to (MERS and SARS also
caused by coronavirus
THE PROTEIN REGULATORY NETWORKS OF COVID-19
WHAT IS COVID-19 AND SARS-COV-2?

9. THE CORONAVIRUS IS VERY MUCH LIKE A COMPUTER VIRUS
Operating
System Files
Root Access
Antivirus
Firewall
Malicious Rootkit
DNA
Skin
Coronavirus
virus
making
machine
Ability to
make
millions of
copies!
Immune
system
Cell
Membrane
THE PROTEIN REGULATORY NETWORKS OF COVID-19

10. THE PROTEIN REGULATORY NETWORKS OF COVID-19
https://www.visualcapitalist.com/visualizing-what-covid-19-does-to-your-body/

11. INNATE VS ADAPTIVE IMMUNE SYSTEM
THE PROTEIN REGULATORY NETWORKS OF COVID-19

13. HOW SARS-COV-2 ENTERS THE CELL
THE PROTEIN REGULATORY NETWORKS OF COVID-19
https://www.antibodies-online.com/

14. QUERYING THE
COVID-19 KNOWLEDGE
GRAPH
https://b14bf0da.databases.neo4j.io/browser/
username: elsevier
password: 3153v13ruser

15. MATCH A LIST OF DRUGS

16. EXPLODE’ ONE OF THE DRUGS

17. FIND OUT WHICH DRUGS DOWN REGULATE ACE2

18. LEARN MORE ABOUT THE PROTEIN VIA KEGG

19. CAN WE COMPENSATE WITH MAS1?

20. LEARN MORE ABOUT N-ACETYLCYSTEINE

21. THANK YOU!