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Mercury

& climate change

Kriya Dunlap
University of Alaska Fairbanks
what do you know about

mercury?
mercury in the environment …
biomagnification and
bioaccumulation
the

risks of mercury exposure
+

H

g
H
C
3

Mercury has a strong
for

sulfhydryl
– S-H

affinity

groups (Thiol)
19th Century

Felters
950’s plastic factory in

Minimata Bay
salmon-fed sled
potential risks and

Mercury levels in

dogs; the
benefits

of subsistence diets
• low incidence
diseases
• 4.8 kg
• 60%

of age and nutritional

subsistence foods

per week

of subsistence foods is

finfish
Village

sled dogs
wild Alaskan

SALMON
the

benefits…

Eicosapentaenoic acid (20:5ω-3)

Docosahexaenoic acid (22:ω-3)

astaxanthin
Phospholipid membrane
Phospholipase
A2
O
HO

Eicosapentaenoicacid
Arachidonic aci

Cyclooxygenases (COX)
Prostaglandins (PG)
&
Thromboxanes (TX)

Lipoxygenases
(LOX)
Leukotrienes
-less biologically active

-poor substrate for cyclooxygena

-gives rise to series 5 leukotri
mercury exposure

What is the
in salmon-fed sled dogs at different location
along the Yukon River

?

health
implications?
What are the
Why the

Yukon

River?

Fort Yukon

Rampart
Galena

Russian Mission

Salcha
Russian

Mission
Ryan Housler
Rampart
Linda Johnson
Galena
Paddy

Nolner
Josh

Cadzow
Sci Total Environ.
3):80-5

2007 Oct 15;385(1-
Why?
Life

Cycle…
Yu
ko
n

Ri
ve
r
Sa
lm
on
Health Implications

of wild AK

salmon?
•WHO Upper Allowable Threshold of 50
ng/g)
•EPA suggests a maximum consumption
of fish per week for a 70 kg person
•Reported adverse effects as low as

ppm

(50,000

of 226 g
300 ng/g

•Russian Mission sled dogs have some of the
highest reported mercury concentrations of any Alaskan
mammal
Future direction…
Special

Thank you

to…
Reynolds
Joee Reddington
Paddy Nolner
Linda Johnson

Cadzow
Scott Campbell
Nestlé Purina
INBRE
Josh

Arleigh

Jr.
Mercury and climate change
Mercury and climate change
Mercury and climate change
Mercury and climate change
Mercury and climate change
Mercury and climate change
Mercury and climate change
Mercury and climate change

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Mercury and climate change

Notes de l'éditeur

  1. Component of many rocks and is released continually, but very slowly into natural waters by normal chemical weathering processes. Small quantities vaporize into the atmosphere from mercury-containing rocks. In bodies of water hg Settle at the body and adhere to sediment. Mercury is used int eh production of chemiscals, paints, plastics, pharmaceuticals, steel, electrical equipment. fungicides.
  2. Elemental mercury not readily absorbed. Anaerobic bacteria in the bottom convert these forms of mercury to organic methyl mercury ion which is very soluble and readily absorbed.
  3. Can damage nervous system, kidneys, liver birth defects.
  4. 1800s that the phrase "mad as a hatter" was coined because of the chronic mercury exposure that the felters faced because mercury was used in hat making. Mercury toxicity in environmental pollution is a major concern because of increased usage of fossil fuels and agricultural products, both of which contain mercury. inorganic form can be further divided into elemental mercury and mercuric salts. Organic mercury can be found in long and short alkyl and aryl compounds. Mercury in any form is toxic. The difference lies in how it is absorbed, the clinical signs and symptoms, and the response to treatment modalities. Mercury poisoning can result from vapor inhalation, ingestion, injection, or absorption through the skin. Neurologic, gastrointestinal, and renal systems are the most commonly affected organ systems in mercury exposur
  5. Environmental Protection Agency (EPA) reduced the allowable intake of methylmercury from 0.5 ug to 0.1 ug of mercury per kilogram per day potential toxic effects (30,000 ng/g; Thompson, 1996). Smith and Armstrong (1975) reported Innuit sled dogs, subsisting largely on seal meat,which had levels ofHg, up to 11,500 ng/g in the liver, without apparent harm. Themean values of THg for theYukonRiver village sled dogs exceed the no effects hazard concentrations for river otters (660 ng/g) and
  6. 50 ppm = 50,000 ng/g Mercury EPA upper allowable limit of 0.1 ug/kg of body weight WHO safe value of 50 ppm hair EPA, WHO, FDA suggest maximum consumption of 226 g of fish per week for a 70 kg person