This document discusses preimplantation genetic screening (PGS) with fresh embryo transfer. It provides an overview of PGS using comprehensive chromosome analysis (CCA) with blastocyst biopsy and either fresh embryo transfer or frozen embryo transfer. Key advantages of CCA with blastocyst biopsy include improved implantation rates, elimination of the negative effect of maternal age on implantation, and the ability to perform embryo banking which facilitates multiple cycles for patients with poor prognosis. Controlled studies show no difference in outcomes between fresh versus frozen embryo transfer when using PGS with CCA.