Computational Protein Design. Overview

•

0 j'aime•699 vues

Pablo Carbonell

Computational Protein Design
Overview

Pablo Carbonell
pablo.carbonell@issb.genopole.fr

iSSB, Institute of Systems and Synthetic Biology
Genopole, University d’Évry-Val d’Essonne, France

mSSB: December 2010

Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 1/3

Overview

1 Challenges in Protein Engineering
The protein design cycle
Types of protein interacions
Locating and introducing the substitutions
Engineering protein activity
Screening and library creation
2 Computational Protein Design
Protein descriptors
Sequence-based methods
Structure-based methods
Search algorithms
De novo design
3 Applications in Systems and Synthetic Biology
Protein afﬁnity enhancement
Protein modular design
Protein promiscuity reengineering
4 Practical exercise

Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 2/3

Computational Protein Design
Overview

Pablo Carbonell
pablo.carbonell@issb.genopole.fr

iSSB, Institute of Systems and Synthetic Biology
Genopole, University d’Évry-Val d’Essonne, France

mSSB: December 2010

Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 3/3

Contenu connexe

En vedette

Protein networks as a scaffold for structuring other data

Protein networks as a scaffold for structuring other data

Protein networks as a scaffold for structuring other data

Lars Juhl Jensen

Cryotherapy of shoot tips is a novel technique used for pathogen eradication from plants, where sample is exposed to a low temperature (-196°C) followed by shoot tip culture. Cryotherapy of shoot tips can result in virus-free plants at a high frequency. Cryotherapy facilitates treatment of large numbers of samples because pathogen eradication by this method is independent of the size of shoot tips used.

Cryotherapy for Pathogen Free Planting Material in Ornamental Crops

Cryotherapy for Pathogen Free Planting Material in Ornamental Crops

Cryotherapy for Pathogen Free Planting Material in Ornamental Crops

Abhay Kumar Gaurav

Plegable Proteínas - Biología Molecular

Plegable Proteínas - Biología Molecular

Plegable Proteínas - Biología Molecular

Software art and design: computational thinking through programming practice ...

Software art and design: computational thinking through programming practice ...

Software art and design: computational thinking through programming practice ...

Aarhus University

MODULAR NATURE OF PROTEINS

MODULAR NATURE OF PROTEINS

MODULAR NATURE OF PROTEINS

SHEIKHASINAH S.M

Aditazz 01-ul

Effect of The Different Auxins and Cytokinins in Callus Induction, Shoot,and...

Effect of The Different Auxins and Cytokinins in Callus Induction, Shoot,and...

Effect of The Different Auxins and Cytokinins in Callus Induction, Shoot,and...

Arghya Narendra Dianastya

zahid hussain ajk

zahid hussain ajk

zahid hussain ajk

W jaki sposób poznać potrzeby ludzi dla których projektujemy? Najczęściej prowadzimy wywiady, dzięki którym dowiadujemy się co ludzie myślą na temat korzystania z produktu bądź usługi. Obserwacje z kolei pomagają zrozumieć w jaki sposób odbiorcy wchodzą w interakcję z produktem czy usługą. A jak dotrzeć do marzeń czy uczuć, których często nie potrafimy werbalnie wyrazić? Jak podczas badań wytworzyć wartość, która zapewni nam sukces rozwiązania? Podczas spotkania Service Design Drinks prezentowałam podejście generative design research przez pryzmat swoich projektów i doświadczeń.

Generative Design Research

Generative Design Research

Generative Design Research

Joanna Rutkowska

Using only simple rules for local interactions, groups of agents can form self-organizing super-organisms or “flocks” that show global emergent behavior. When agents are also extended with memory and goals the resulting flock not only demonstrates emergent behavior, but also collective intelligence: the ability for the group to solve problems that might be beyond the ability of the individual alone. Until now, research has focused on the improvement of particle design for global behavior; however, techniques for human-designed particles are task-specific. In this paper we will demonstrate that evolutionary computing techniques can be applied to design particles, not only to optimize the parameters for movement but also the structure of controlling finite state machines that enable collective intelligence. The evolved design not only exhibits emergent, self-organizing behavior but also significantly outperforms a human design in a specific problem domain. The strategy of the evolved design may be very different from what is intuitive to humans and perhaps reflects more accurately how nature designs systems for problem solving. Furthermore, evolutionary design of particles for collective intelligence is more flexible and able to target a wider array of problems either individually or as a whole.

Evolutionary Design of Swarms (SSCI 2014)

Evolutionary Design of Swarms (SSCI 2014)

Evolutionary Design of Swarms (SSCI 2014)

Benjamin Bengfort

Parametric Architecture Talk (Presented 13 March 2013)

Parametric Architecture Talk (Presented 13 March 2013)

Parametric Architecture Talk (Presented 13 March 2013)

Developing an Efficient Infrastruture, Standards and Data-Flow for Metabolomics

Developing an Efficient Infrastruture, Standards and Data-Flow for Metabolomics

Developing an Efficient Infrastruture, Standards and Data-Flow for Metabolomics

Christoph Steinbeck

The types of tissue culture can be grouped by the structures formed in culture. Plantlets Seedlings Callus Somatic EmbryogenesisPlantlet formationThis is the most common form of micropropagation. Uses a portion of the stem with one to several nodes 1. Axillary shoot formation Meristem culture Shoot culture 2. Adventitious shoot formation Diploid plant regenerationPseudocorms Pseudocorms are the structures initiated after seed germination in orchids Haploid and triploid regeneration

Plant tissue culture march 2

Plant tissue culture march 2

Plant tissue culture march 2

Dr. sreeremya S

Plant tissue culture

Plant tissue culture

Plant tissue culture

Punjab Technical Univesity

Natural and artificial regeneration

Natural and artificial regeneration

Natural and artificial regeneration

Vivek Srivastava

Plasma protiens and their clinical significance

Plasma protiens and their clinical significance

Plasma protiens and their clinical significance

ThoughtWorks Luminary and Conference Presenter Extraordinaire Neal Ford will be presenting: Emergent Design & Evolutionary Architecture Most of the software world has realised that Big Design Up Front (BDUF) doesn’t work well in software. But lots of developers struggle with this notion when it applies to architecture and design, surely you can’t start coding, right? You need some level of understanding before you can start work. This seminar will explore the current thinking about Emergent Design and Evolutionary Architecture, including: • Proactive approaches with test driven development • Reactive approaches including both refactoring and composed methods • Strategies and techniques for allowing design to emerge from projects as they proceed, keeping your code in sync with the problem domain • Real world examples of these techniques in action Neal Ford, Software Architect and Meme Wrangler, ThoughtWorks Neal is an acclaimed international speaker and expert on designing and building of large-scale enterprise applications. Neal has spoken at over 100 conferences worldwide, delivering more than 600 talks. Neal is also the designer and developer of applications, instructional materials, magazine articles, courseware, video/DVD presentations and author and/or editor of 6 books spanning a variety of technologies, including the most recent The Productive Programmer.

Neal Ford Emergent Design And Evolutionary Architecture

Neal Ford Emergent Design And Evolutionary Architecture

Neal Ford Emergent Design And Evolutionary Architecture

Lesson 1 parametric design 2 final

Lesson 1 parametric design 2 final

Lesson 1 parametric design 2 final

Sars Presentation

Sars Presentation

Sars Presentation

Generative design

Generative design

Generative design

En vedette (20)

Protein networks as a scaffold for structuring other data

Protein networks as a scaffold for structuring other data

Protein networks as a scaffold for structuring other data

Cryotherapy for Pathogen Free Planting Material in Ornamental Crops

Cryotherapy for Pathogen Free Planting Material in Ornamental Crops

Cryotherapy for Pathogen Free Planting Material in Ornamental Crops

Plegable Proteínas - Biología Molecular

Plegable Proteínas - Biología Molecular

Plegable Proteínas - Biología Molecular

Software art and design: computational thinking through programming practice ...

Software art and design: computational thinking through programming practice ...

Software art and design: computational thinking through programming practice ...

MODULAR NATURE OF PROTEINS

MODULAR NATURE OF PROTEINS

MODULAR NATURE OF PROTEINS

Aditazz 01-ul

Effect of The Different Auxins and Cytokinins in Callus Induction, Shoot,and...

Effect of The Different Auxins and Cytokinins in Callus Induction, Shoot,and...

Effect of The Different Auxins and Cytokinins in Callus Induction, Shoot,and...

zahid hussain ajk

zahid hussain ajk

zahid hussain ajk

Generative Design Research

Generative Design Research

Generative Design Research

Evolutionary Design of Swarms (SSCI 2014)

Evolutionary Design of Swarms (SSCI 2014)

Evolutionary Design of Swarms (SSCI 2014)

Parametric Architecture Talk (Presented 13 March 2013)

Parametric Architecture Talk (Presented 13 March 2013)

Parametric Architecture Talk (Presented 13 March 2013)

Developing an Efficient Infrastruture, Standards and Data-Flow for Metabolomics

Developing an Efficient Infrastruture, Standards and Data-Flow for Metabolomics

Developing an Efficient Infrastruture, Standards and Data-Flow for Metabolomics

Plant tissue culture march 2

Plant tissue culture march 2

Plant tissue culture march 2

Plant tissue culture

Plant tissue culture

Plant tissue culture

Natural and artificial regeneration

Natural and artificial regeneration

Natural and artificial regeneration

Plasma protiens and their clinical significance

Plasma protiens and their clinical significance

Plasma protiens and their clinical significance

Neal Ford Emergent Design And Evolutionary Architecture

Neal Ford Emergent Design And Evolutionary Architecture

Neal Ford Emergent Design And Evolutionary Architecture

Lesson 1 parametric design 2 final

Lesson 1 parametric design 2 final

Lesson 1 parametric design 2 final

Sars Presentation

Sars Presentation

Sars Presentation

Generative design

Generative design

Generative design

Dernier

ODC, Data Fabric and Architecture User Group

ODC, Data Fabric and Architecture User Group

ODC, Data Fabric and Architecture User Group

CatarinaPereira64715

Speed Wins: From Kafka to APIs in Minutes

Speed Wins: From Kafka to APIs in Minutes

Speed Wins: From Kafka to APIs in Minutes

AI presentation and introduction - Retrieval Augmented Generation RAG 101

AI presentation and introduction - Retrieval Augmented Generation RAG 101

AI presentation and introduction - Retrieval Augmented Generation RAG 101

IESVE for Early Stage Design and Planning

IESVE for Early Stage Design and Planning

IESVE for Early Stage Design and Planning

The presentation underscores the strategic advantage of treating design systems not just as technical assets but as vital business components that require thoughtful management, robust planning, and strategic alignment with organizational goals. Key Points Covered: - Understanding Design Systems as Business Entities: Conceptualizing design systems as internal business entities can streamline their integration and evolution within a company. - Adoption and Expansion: Elaborating on the importance of tactical adoption across organizational structures, enhancing product suites to cater to user needs and broadening scope to mobile and content authoring solutions. - Data-Driven Development: Utilizing data insights for component development ensures that resources are allocated to create valuable, widely used features. - Financial Modeling for Design Systems: Developing sustainable funding models is crucial for long-term support and success of design systems. - Promoting Internal Buy-In: Stressing on strategies for promoting design systems within the organization to increase engagement and investment from internal stakeholders.

A Business-Centric Approach to Design System Strategy

A Business-Centric Approach to Design System Strategy

A Business-Centric Approach to Design System Strategy

Measures in SQL (a talk at SF Distributed Systems meetup, 2024-05-22)

Measures in SQL (a talk at SF Distributed Systems meetup, 2024-05-22)

Measures in SQL (a talk at SF Distributed Systems meetup, 2024-05-22)

Ever caught yourself nodding along when someone mentions "delivering value" in Agile, but secretly wondering what the heck they actually mean? You're not alone! Join us for an eye-opening session where we'll strip away the buzzwords and dive into the heart of Agile—value delivery. But what is "value"? Is it a mythical unicorn in the world of software development, or is there more to this overused term? This isn't going to be a sit-and-get lecture. We're talking about a face-to-face, interactive meetup where YOU play a crucial role. Come along to: Define It: What does "value" really mean? We’ll build a definition that’s not just words, but a compass for your Agile journey. Contextualise It: Discover what value means specifically to you, your team, your company, and your industry. Because one size does not fit all. Deliver It: Share strategies and gather new ones for uncovering and delivering true value—no more shooting in the dark!

Unpacking Value Delivery - Agile Oxford Meetup - May 2024.pptx

Unpacking Value Delivery - Agile Oxford Meetup - May 2024.pptx

Unpacking Value Delivery - Agile Oxford Meetup - May 2024.pptx

As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other? Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.

Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024

Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024

Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024

Discover the essentials of performance testing in the IT sector with our concise guide. Learn about various testing types such as load, stress, endurance, spike, scalability, and volume testing. Understand key performance metrics like response time, throughput, CPU and memory utilization, and error rate. Explore top tools like Apache JMeter, LoadRunner, Gatling, Neoload, and BlazeMeter. Gain insights into best practices for defining objectives, creating realistic scenarios, automating tests, and optimizing performance to ensure user satisfaction, reliability, scalability, and cost efficiency. Ideal for developers, QA engineers, and IT professionals. Visit Expeed Software for more information. https://expeed.com/

In-Depth Performance Testing Guide for IT Professionals

In-Depth Performance Testing Guide for IT Professionals

In-Depth Performance Testing Guide for IT Professionals

Expeed Software

Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application. In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics. Length: 30 minutes Session Overview ------------------------------------------- During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana: - What out-of-the-box solutions are available for real-time monitoring JMeter tests? - What are the benefits of integrating InfluxDB and Grafana into the load testing stack? - Which features are provided by Grafana? - Demonstration of InfluxDB and Grafana using a practice web application To view the webinar recording, go to: https://www.rttsweb.com/jmeter-integration-webinar

JMeter webinar - integration with InfluxDB and Grafana

JMeter webinar - integration with InfluxDB and Grafana

JMeter webinar - integration with InfluxDB and Grafana

The New York Times continues to lead in user-centered design by innovating and adapting to enhance both user engagement and understanding, aligning product experiences with its journalistic mission. This presentation discusses innovative strategies in user experience at The New York Times, focusing on subscriber experiences and storytelling. Key Points Covered: - Mission-Driven Design: Emphasizing the Times' mission to "seek the truth and help people understand the world," the design team prioritizes clarity and engagement to support high-quality journalism. - UX Design Principles: The team follows five core UX tenets—clarity, time optimization, craftsmanship, accessibility, and trust—to maintain a strong focus on user-centric design. - Innovative Design Strategies: Product Feature Advancement, Editorial Expression, Long-term Visioning - Integrating Diverse Content: Examples include the successful integration of popular games like Wordle, which not only entertain but also attract and retain a diverse user base.

Transforming The New York Times: Empowering Evolution through UX

Transforming The New York Times: Empowering Evolution through UX

Transforming The New York Times: Empowering Evolution through UX

This presentation discusses the complexities of aligning teams and ensuring consistent product experiences across various platforms, proposing Server Driven UI (SDUI) as a solution. Key Points Covered: - The challenge of maintaining consistency in product experiences across web and app interfaces, highlighted by discrepancies in user experience features like comment sections. - Introduction of Server Driven UI (SDUI) to manage uniformity and streamline updates across different platforms. - The importance of adapting design systems to accommodate SDUI, ensuring uniform naming conventions, and component functionalities. - Technical discussions on overcoming framework differences and the operational load on developers due to continuous OS updates.

Server-Driven User Interface (SDUI) at Priceline

Server-Driven User Interface (SDUI) at Priceline

Server-Driven User Interface (SDUI) at Priceline

I'm excited to share my latest predictions on how AI, robotics, and other technological advancements will reshape industries in the coming years. The slides explore the exponential growth of computational power, the future of AI and robotics, and their profound impact on various sectors. Why this matters: The success of new products and investments hinges on precise timing and foresight into emerging categories. This deck equips founders, VCs, and industry leaders with insights to align future products with upcoming tech developments. These insights enhance the ability to forecast industry trends, improve market timing, and predict competitor actions. Highlights: ▪ Exponential Growth in Compute: How $1000 will soon buy the computational power of a human brain ▪ Scaling of AI Models: The journey towards beyond human-scale models and intelligent edge computing ▪ Transformative Technologies: From advanced robotics and brain interfaces to automated healthcare and beyond ▪ Future of Work: How automation will redefine jobs and economic structures by 2040 With so many predictions presented here, some will inevitably be wrong or mistimed, especially with potential external disruptions. For instance, a conflict in Taiwan could severely impact global semiconductor production, affecting compute costs and related advancements. Nonetheless, these slides are intended to guide intuition on future technological trends.

Future Visions: Predictions to Guide and Time Tech Innovation, Peter Udo Diehl

Future Visions: Predictions to Guide and Time Tech Innovation, Peter Udo Diehl

Future Visions: Predictions to Guide and Time Tech Innovation, Peter Udo Diehl

Peter Udo Diehl

This talk focuses on the practical aspects of integrating various telephony systems with Salesforce, drawing on examples from implementations in the Czech scene. It aims to inform attendees about the spectrum of telephony solutions available, from small to large scale, and their compatibility with Salesforce. The presentation will highlight key considerations for selecting a telephony provider that integrates smoothly with Salesforce, including important questions to support the decision-making process. It will also discuss methods for integrating existing telephony systems with Salesforce, aimed at companies contemplating or in the process of adopting this CRM platform. The discussion is designed to provide a straightforward overview of the steps and considerations involved in telephony and Salesforce integration, with an emphasis on functionality, compatibility, and the practical experiences of Czech companies.

Integrating Telephony Systems with Salesforce: Insights and Considerations, B...

Integrating Telephony Systems with Salesforce: Insights and Considerations, B...

Integrating Telephony Systems with Salesforce: Insights and Considerations, B...

The standard Salesforce Approval process can be limiting in many ways, especially in complex scenarios. What if there was a way to implement very flexible approvals where one can use Apex code to make data updates in unrelated records, dynamically generate next steps details, and compute assignees on the fly? And still use UI-based configurations to implement concrete approval processes. In this session, we will share ideas behind such a solution and show a few lines of code to get you started.

Custom Approval Process: A New Perspective, Pavel Hrbacek & Anindya Halder

Custom Approval Process: A New Perspective, Pavel Hrbacek & Anindya Halder

Custom Approval Process: A New Perspective, Pavel Hrbacek & Anindya Halder

What's New in Teams Calling, Meetings and Devices April 2024

What's New in Teams Calling, Meetings and Devices April 2024

What's New in Teams Calling, Meetings and Devices April 2024

Stephanie Beckett

We're living the AI revolution and Salesforce is adapting and bring new value to their customers. Einstein products are evolving rapidly and navigating their limitations, language support, and use cases can be challenging. Let's make review of what Einstein product are available currently, what are the capabilities and what can be used for in CEE region and how Rossie.ai can help to learn Salesforce speak Czech. We will explore the Einstein roadmap and I will make a short live demo (based on your vote) of some Einstein feature.

AI revolution and Salesforce, Jiří Karpíšek

AI revolution and Salesforce, Jiří Karpíšek

AI revolution and Salesforce, Jiří Karpíšek

In an era where artificial intelligence (AI) is becoming increasingly integrated into our daily lives, the need for empathetic technology is paramount. This talk explores the role of motion design in enhancing AI interfaces to foster empathy and improve user experiences. Key Topics Covered: 1. Introduction to Empathetic AI - The importance of creating empathy in AI interfaces - Personal journey from character animation to AI and robotics design 2. The Role of Motion in User Interaction - Historical context of motion in design, from early Disney animations to modern interfaces - The blinking cursor: An example of effective motion use since 1960 3. Designing for Empathy - How motion can enhance user satisfaction and trust in AI systems - Examples from human-robot interaction and AI interfaces 4. Creating Human-like Interactions - Using motion to provide transparency and context in AI interactions - The importance of natural conversation flows and the ability to interrupt AI responses 5. Avoiding the Uncanny Valley - Recognizing and mitigating the uncanny valley in AI-generated content - Examples of effective and ineffective uses of motion in AI 6. Systemizing Motion Design - Strategies for integrating motion into AI systems at scale - Salesforce’s approach to creating and scaling a motion system for AI

Motion for AI: Creating Empathy in Technology

Motion for AI: Creating Empathy in Technology

Motion for AI: Creating Empathy in Technology

When you think of a highly secure meeting environment, do you instantly think 'Microsoft Teams'!? Or do you think about some unknown application, troublesome UI and daunting login process...? If you think the latter - let's change that! In this session Femke will show you how using Teams Premium features can create secure, but also good looking meetings! PRETTY. Make sure your company's brand is represented before, during and after the meeting with Customization policies in place. SECURE. Lets utilize Meeting templates and Sensitivity Labels to protect your meeting and data to prevent sensitive information from being leaked. After this session, you will have a clear understanding of the capabilities of Teams Premium features and how to set up the perfect meeting that suits your organizational requirements!

ECS 2024 Teams Premium - Pretty Secure

ECS 2024 Teams Premium - Pretty Secure

ECS 2024 Teams Premium - Pretty Secure

Femke de Vroome

Intelligent Gimbal FINAL PAPER Engineering.pdf

Intelligent Gimbal FINAL PAPER Engineering.pdf

Intelligent Gimbal FINAL PAPER Engineering.pdf

Anthony Lucente

Dernier (20)

ODC, Data Fabric and Architecture User Group

ODC, Data Fabric and Architecture User Group

ODC, Data Fabric and Architecture User Group

Speed Wins: From Kafka to APIs in Minutes

Speed Wins: From Kafka to APIs in Minutes

Speed Wins: From Kafka to APIs in Minutes

AI presentation and introduction - Retrieval Augmented Generation RAG 101

AI presentation and introduction - Retrieval Augmented Generation RAG 101

AI presentation and introduction - Retrieval Augmented Generation RAG 101

IESVE for Early Stage Design and Planning

IESVE for Early Stage Design and Planning

IESVE for Early Stage Design and Planning

A Business-Centric Approach to Design System Strategy

A Business-Centric Approach to Design System Strategy

A Business-Centric Approach to Design System Strategy

Measures in SQL (a talk at SF Distributed Systems meetup, 2024-05-22)

Measures in SQL (a talk at SF Distributed Systems meetup, 2024-05-22)

Measures in SQL (a talk at SF Distributed Systems meetup, 2024-05-22)

Unpacking Value Delivery - Agile Oxford Meetup - May 2024.pptx

Unpacking Value Delivery - Agile Oxford Meetup - May 2024.pptx

Unpacking Value Delivery - Agile Oxford Meetup - May 2024.pptx

Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024

Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024

Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024

In-Depth Performance Testing Guide for IT Professionals

In-Depth Performance Testing Guide for IT Professionals

In-Depth Performance Testing Guide for IT Professionals

JMeter webinar - integration with InfluxDB and Grafana

JMeter webinar - integration with InfluxDB and Grafana

JMeter webinar - integration with InfluxDB and Grafana

Transforming The New York Times: Empowering Evolution through UX

Transforming The New York Times: Empowering Evolution through UX

Transforming The New York Times: Empowering Evolution through UX

Server-Driven User Interface (SDUI) at Priceline

Server-Driven User Interface (SDUI) at Priceline

Server-Driven User Interface (SDUI) at Priceline

Future Visions: Predictions to Guide and Time Tech Innovation, Peter Udo Diehl

Future Visions: Predictions to Guide and Time Tech Innovation, Peter Udo Diehl

Future Visions: Predictions to Guide and Time Tech Innovation, Peter Udo Diehl

Integrating Telephony Systems with Salesforce: Insights and Considerations, B...

Integrating Telephony Systems with Salesforce: Insights and Considerations, B...

Integrating Telephony Systems with Salesforce: Insights and Considerations, B...

Custom Approval Process: A New Perspective, Pavel Hrbacek & Anindya Halder

Custom Approval Process: A New Perspective, Pavel Hrbacek & Anindya Halder

Custom Approval Process: A New Perspective, Pavel Hrbacek & Anindya Halder

What's New in Teams Calling, Meetings and Devices April 2024

What's New in Teams Calling, Meetings and Devices April 2024

What's New in Teams Calling, Meetings and Devices April 2024

AI revolution and Salesforce, Jiří Karpíšek

AI revolution and Salesforce, Jiří Karpíšek

AI revolution and Salesforce, Jiří Karpíšek

Motion for AI: Creating Empathy in Technology

Motion for AI: Creating Empathy in Technology

Motion for AI: Creating Empathy in Technology

ECS 2024 Teams Premium - Pretty Secure

ECS 2024 Teams Premium - Pretty Secure

ECS 2024 Teams Premium - Pretty Secure

Intelligent Gimbal FINAL PAPER Engineering.pdf

Intelligent Gimbal FINAL PAPER Engineering.pdf

Intelligent Gimbal FINAL PAPER Engineering.pdf

Computational Protein Design. Overview

1. Computational Protein Design Overview Pablo Carbonell pablo.carbonell@issb.genopole.fr iSSB, Institute of Systems and Synthetic Biology Genopole, University d’Évry-Val d’Essonne, France mSSB: December 2010 Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 1/3

2. Overview 1 Challenges in Protein Engineering The protein design cycle Types of protein interacions Locating and introducing the substitutions Engineering protein activity Screening and library creation 2 Computational Protein Design Protein descriptors Sequence-based methods Structure-based methods Search algorithms De novo design 3 Applications in Systems and Synthetic Biology Protein afﬁnity enhancement Protein modular design Protein promiscuity reengineering 4 Practical exercise Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 2/3

3. Computational Protein Design Overview Pablo Carbonell pablo.carbonell@issb.genopole.fr iSSB, Institute of Systems and Synthetic Biology Genopole, University d’Évry-Val d’Essonne, France mSSB: December 2010 Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 3/3