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By: PH. Amani Al-Ismail PH. Marwa Chalati Tumor suppressor Gene
OUTLINE ,[object Object],Introduction Definition Regulation of cell cycle Tumor suppressor genes: Overview Function Types Examples
introduction ,[object Object]
 
Regulation of cell cycle
 
 
 
 
[object Object]
What different mechanisms they do?
Rb Gene
P53 Gene
Overview Of Tumor Suppressor Genes ,[object Object],[object Object]
What are Tumor suppressor genes ?
[object Object],[object Object]
Biological Function Of Tumor Suppressor Genes
Types of Tumor Suppressor Genes
Some examples of Tumor suppressor Genes Fore of these genes have mainly study and absence of their product lead to development various of malignant tumor   ISOLATE CROMOSOM CANCER GENE 1986 Crom.13q Retinoblastoma RB 1990 Crom.17p Osteosaracoma P53 1991 Crom.5q Colon APC 1993 Crom.3p Renal carcinoma VHL 1994 Crom.9p Melanoma P16 1994 Crom.17q Brest censer BRCA1 1995 Crom.13q Brest censer BRCA2
Retinoblastoma(R b ) gene
Retinoblastoma ,[object Object],[object Object]
 
 
    p53 A key tumor suppressor The guardian of the genome
Li-Fraumeni syndrome  (LFS) ,[object Object],[object Object]
BRCA1 and BRCA2 genes ,[object Object]
Stimuli that affect Tumor Suppressor Genes Levels ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Future Directions  ,[object Object]
 
 
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Tumor suppressor gene