19. Some examples of Tumor suppressor Genes Fore of these genes have mainly study and absence of their product lead to development various of malignant tumor ISOLATE CROMOSOM CANCER GENE 1986 Crom.13q Retinoblastoma RB 1990 Crom.17p Osteosaracoma P53 1991 Crom.5q Colon APC 1993 Crom.3p Renal carcinoma VHL 1994 Crom.9p Melanoma P16 1994 Crom.17q Brest censer BRCA1 1995 Crom.13q Brest censer BRCA2