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1. PILOT SCALE TECHNIQUE FORGINGER OIL FROM GINGER BY AVS. PRAVEEN KUMAR I M.PHARMACY

2. PLANT: It is considered as the place where material,men,method and machine are brought together for the manufacturing of products. PILOT SCALEUP: It refers to the art of designing a lab scale formula for the production. PILOT SCALE TECHNIUE

4. WHY TO CONDUCT PILOT PLANT STUDIES A pilot scale up technique is an intermediate scale for estimation & assessment of a product and process on before huge amounts of money invest for large scale production. It is not possible to design a large scale processing plant from laboratory data alone with any degree of success.

5. GINGER OIL

7. Extraction.

8. Analysis.

10. GINGER OIL PROPERTIES Ginger oil is pale yellow in color, has a fresh, agreeable & aromatic smell, has strong and characteristic odour. The shelf life of Ginger oil is very long and it is Stable at room temperature. So it is used in aromatherapy also in fragrance therapy.

11. CHEMICAL CONSTITUENTS OF GINGER OIL Zingiberine35% ᵝsesquiphellandrene 10% BisaBolene8% Dexto-camphene 6% Beta-phellandrene3% 1,8-cineole 2% Others 26%

12. Chemial structures: 6-gingerol zingeberene 8-gingerol zingiberol

14. Digestive,

15. Carminative,

16. Expectorant,

17. Antiseptic,

18. Analgesic,

19. Anti pyretic,

20. Simulating and aphrodisiac properties.

22. TYPES IN DRYING Ground dried ginger. Fresh sliced ginger (0% dryness).

23. Dried sliced ginger (90% dryness). Dryness (%) = Initial weight of sample (g) - Current weight of sample Dryness (%) (g)|x 100 Initial weight (g)

25. Infusion

26. Maceration

27. Percolation

28. Soxhlation

29. Soxtec

30. M.A. E

31. Ultra Sonication

32. Spouted Bed Extraction

33. Steam Distillation:

34. Super Critical Fluid Extraction (SFE):

35. R.P.E

37. Condenser Dean stark Separating funnel Pressure cooker The water and steam distillation unit at CLEAR

38. SUPERCRITICAL FLUID EXTRACTION (SFE)

39. TLC PROFILE OF GINGER OIL Sample detail : Ginger Oil ( Zingiberofficinale) Adsorbent : Precoatedsilicagel Mobile Phase : Toulene : EthylAcetate (93:7) Sample preparation: 1 gm of Zingiberofficinale oil was dissolved in chloroform and 10ml applied on the TLC plate. Solvent front run upto : 9 cms Detection :AnisaldihydeSulphuric acid reagent (Fig.1) Vanillin sulphuric acid (Fig.2). Scanning : 254 nm

40. Fig. 1 Fig. 2 Rf. =0.9 – Zingiberene (red spot) ~

41. Storage & Packing

42. References:1. Pharmacognosy, by Dr.C.K. Kokate , A.P. Purohit,S.B. GokhaleNiraliPrakashan, 38th edition, 2007.2. Qulity control of herbal drugs by Pollok Mukhergy3. Wagner H, et al, Plant Drug Analysis, Spinger, 1996, 3004.British Pharmacopoeia, 3055. Indian Standard Specification for Oil of Ginger, 1st Revision.6. Herbal Drug Technology by Prof S.S Agarwal 7. Online library wiley.com

43. THANK YOU