Cluster Headache is a major headache and is very common in a group of head problems called trigeminal autonomic cephalalgias. The term cluster headache comes from the fact that the attack occurred in groups, or “clusters.” During the group cycle, severe headaches also occur between 1─8 times a day. Cluster cycles can last for weeks or months and are usually terminated during periods of remission, or periods of headaches. It usually occurs at the age of 20-40 and this condition is more common in men than women. It contains a headache on one side of the head. It is related to symptoms that occur on the same side of the head where the pain persists, runny or crooked nose, including red or clear eye, and spraying or sweating of the face.

1. Cluster Headache (CH) Overview
Cluster Headache is a major headache and is very common in a group of head
problems called trigeminal autonomic cephalalgias. The term cluster headache
comes from the fact that the attack occurred in groups, or “clusters.” During the
group cycle, severe headaches also occur between 1─8 times a day. Cluster
cycles can last for weeks or months and are usually terminated during periods of
remission, or periods of headaches. It usually occurs at the age of 20-40 and this
condition is more common in men than women. It contains a headache on one
side of the head. It is related to symptoms that occur on the same side of the head
where the pain persists, runny or crooked nose, including red or clear eye, and
spraying or sweating of the face.
Cluster Headache Causes
● The exact cause of cluster heads is unknown, but cluster patterns suggest
that abnormalities in the body's hypothalamus play a role.
● Unlike migraine and tension headache, cluster headache is usually not
associated with causes, such as diet, hormonal changes, or depression.
● As soon as the collection time begins, however, alcohol consumption can
quickly start a divisive headache. For this reason, many people with a
cluster head avoid alcohol during the collection.
● Other possible causes include the use of drugs such as nitroglycerin, a
drug used to treat heart disease.
Cluster Headache Signs and Symptoms

2. The cluster's head strikes quickly, usually without warning, although you may
begin to experience nausea such as migraine and aura. Common signs and
symptoms during a headache include:
1. Pain on one side
2. Instability
3. Extreme sadness
4. Redness of your eye on the affected side
5. The stuffy or runny nose on the affected side
6. Forehead or facial sweating on the affected side
7. Pale skin or wrinkles on your face
8. Swelling around your eye on the affected side
9. Drooping eyelid to the affected side
Unlike those with migraines, people with cluster headaches are more likely to
walk faster or stay back and forth. Other symptoms such as migraine - including
sensitivity to light and noise - can occur with the head of the group, however on
one side.
Cluster Headache (CH) Epidemiology Insights
According to the World Health Organization (WHO) cluster headache is
comparatively rare and it affects fewer than one in 1,000 adults which affects six
men to each woman (“Headache disorders,” n.d.)
According to the research study of Fischera et al., the pooled data for cluster
headache showed that the lifetime prevalence of 124 per 100,000 and a 1 year
prevalence of 53 per 100,000 (Fischera, Marziniak, Gralow, & Evers, 2008).
Cluster Headache (CH) Market Outlook
Cluster headache is a neurovascular rather than a vascular headache, with
vascular cerebral changes being focused by the effects of trigeminal-autonomic
reflex activation. The trigeminal-autonomic reflex is a pathway that consists of a
brainstem linking between the trigeminal nerve and facial cranial nerve
parasympathetic outflow and is activated with the stimulation of the
trigeminovascular pathways.

3. There is an advancement in the understanding of the cluster headache
pathophysiology, which has led to the improved characterization and diagnosis of
the clinical features. For treatment to be effective, the correct diagnosis must be
made followed by choice of treatment, taking into account the severity and
frequency of attacks, other symptoms, patient preference, history of treatment,
and comorbid conditions.
The dynamics of the Cluster Headache market is expected to change in the
coming years owing to the improvement in the diagnosis methodologies,
increasing awareness of the disease, and incremental healthcare spending
across the world. Key players in the therapeutic market of Cluster Headache are
Zosano Pharma and Mind Medicine (MindMed) etc. The launch of emerging
therapies, such as LSD (Mind Medicine (MindMed)) and C213 Microneedle
System (Zosano Pharma) will significantly impact the Cluster Headache market
during the forecast period (2020–2030).