1. INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part IV Adrenergic and cholinergic receptors

2. Adrenergic Receptors: Receptors Activated by EPI/NE   -adrenergic receptors (Epinephrine>Isoproterenol)  -adrenergic receptors (Isoproterenol>Epinephrine)  1 -adrenergic receptors (Phenylephrine>Clonidine)  2 -adrenergic receptors (Clonidine>Phenylephrine)  1 -adrenergic receptors (EPI = NE)  2 -adrenergic receptors (EPI>NE)  3 -adrenergic receptors (NE>EPI)

3. Adrenergic Receptors: Signal Transduction

4. Signal Transduction by  1 - Adrenergic Receptors G q q q

5. Signal Transduction by  2 - and  - Adrenergic Receptors

6. Nicotinic Receptors (Activated by nicotine from tobacco) M 2 (Heart & SM) M 3 (Heart & SM) M 4 (SM & Glands) M 5 (?) N M (Neuromuscular) N N Autonomic ganglia, Adrenal medulla & CNS (Blocked by Trimethaphan) (Blocked by Tubocurarine) (Defined by Molecular Cloning) Muscarinic Receptors (Activated by muscarine from Amanita muscaria) Cholinergic Receptors: Receptors Activated by Ach M 1 (Nerve Cells)

7. Cholinergic Receptors: Signal Transduction

8. Formation of IP 3 Formation of DAG Release of Intracellular Calcium Activation of PKC  subunit Inhibition of Adenylyl Cyclase Opening of Potassium Channels Activation of PLC G q Muscarinic Receptors  subunit G i