Compound Exchange Standards

•Télécharger en tant que PPTX, PDF•

0 j'aime•524 vues

Ramesh Durvasula (BMS) provides an overview of this potential Pistoia Alliance working group during the Dragons' Den session at the Pistoia Alliance Conference in Boston, MA, on April 24, 2012.

Technologie Business

Pistoia Dragon’s Den

Restricted Compound List
Management

1

Business Challenge

• Legislation exists at local, national and
international levels to restrict the
production, import/export, supply, use
and possession of certain substances
• Pharmaceutical companies must hold
multiple licences to conduct research
across the field of restricted compounds

2

Business Challenge

• Legislation is constantly evolving and becoming
more complicated as it attempts to mirror
developments in substance abuse

mephedrone

U.S. bans chemicals in "bath salts" street drug

methylenedioxypyrovalerone (MDPV) 3

Vision for this Project

‘The list’ – a single source of restricted
compound knowledge for the pharmaceutical
industry
– Totally comprehensive in regards to current legislation
– Have knowledge of all pending/proposed legislation – keep the pharma industry
‘ahead of the game’
– Have global coverage – it must be possible to check against the restricted
compound law in any country/region or check against global legislation
– Have complete and correct interpretation of legislation, this interpretation being
confirmed by the legislative body concerned
– Ideally be ‘certified’ by governments, i.e. use this list and you will be compliant
– The list to be provided as required by the industry – Individual Structures
(Molfiles, SMILES, INCHI, etc) , Markushes, Compound Names (INN, Trademark,
etc), CAS No’s, other identifiers as required, legal status, legal documentation,
etc.

4

Business Case: Restricted Compounds List

• Project cost
– $300,000 one-time, plus $100,000 annually
• Value Created
– Reduce annual cost of $100,000 per company

5

Contenu connexe

Plus de Pistoia Alliance

Fairification experience clarifying the semantics of data matrices

Pistoia Alliance

Innovation applications of microphysiological systems (MPS) have been growing over the past decade, especially with respect to the use of complex human tissues for assessing safety of drug candidates – but broad industry adoption of MPS methods has not yet become a reality. This webinar addresses some recent advances in MPS development and begins to explore the barriers to increased incorporation of MPS to improve drug safety assessment and to provide safer, more effective drugs into the clinical pipeline.

MPS webinar master deck

Pistoia Alliance

Federated Learning (FL) is a learning paradigm that enables collaborative learning without centralizing datasets. In this webinar, NVIDIA present the concept of FL and discuss how it can help overcome some of the barriers seen in the development of AI-based solutions for pharma, genomics and healthcare. Following the presentation, the panel debate on other elements that could drive the adoption of digital approaches more widely and help answer currently intractable science and business questions.

Digital webinar master deck final

Pistoia Alliance

It seems that AI is also becoming a buzzword, like design thinking. Everyone is talking about AI or wants to have AI, and sees all the ideas and benefits – that’s fine, but how do you get started? But what’s different now? Three innovations have finally put AI on the fast track: Big Data, with the internet and sensors everywhere; massive computing power, especially through the Cloud; and the development of breakthrough algorithms, so computers can be trained to accomplish more sophisticated tasks on their own with deep learning. If you use new technology, you need to explore and know what’s possible. With design thinking, it aids to outline the steps and define the ways in which you’re going to create the solution. Starting with mapping the customer journey, defining who will be using that service enhanced with intelligent technology, or who will benefit and gain value from it. We discuss how these two worlds are coming together, and how you get started to transform your venture with Artificial Intelligence using Design Thinking. Speaker: Claudio Mirti, Principal Solution Specialist – Data & AI, Microsoft

Heartificial intelligence - claudio-mirti

Pistoia Alliance

Themes and objectives: To position FAIR as a key enabler to automate and accelerate R&D process workflows FAIR Implementation within the context of a use case Grounded in precise outcomes (e.g. faster and bigger science / more reuse of data to enhance value / increased ability to share data for collaboration and partnership) To make data actionable through FAIR interoperability Speakers: Mathew Woodwark,Head of Data Infrastructure and Tools, Data Science & AI, AstraZeneca Erik Schultes, International Science Coordinator, GO-FAIR Georges Heiter, Founder & CEO, Databiology

Fair by design

Pistoia Alliance

Knowledge graphs ilaria maresi the hyve 23apr2020

Pistoia Alliance

This presentation described how data-driven chemoinformatics methods may automate much of what has historically been done by a medicinal chemist. It explored what is reasonable to expect “AI” approaches might achieve, and what is best left with a human expert. The implications of automation for the human-machine interface were explored and illustrated with examples from Bradshaw, GSK’s experimental automated design environment.

2020.04.07 automated molecular design and the bradshaw platform webinar

Pistoia Alliance

Data market evolution, a future shaped by FAIR

Pistoia Alliance

Dr. Dennis Wang discusses possible ways to enable ML methods to be more powerful for discovery and to reduce ambiguity within translational medicine, allowing data-informed decision-making to deliver the next generation of diagnostics and therapeutics to patients quicker, at lowered costs, and at scale. The talk by Dr. Dennis Wang was followed by a panel discussion with Mr. Albert Wang, M. Eng., Head, IT Business Partner, Translational Research & Technologies, Bristol-Myers Squibb.

AI in translational medicine webinar

Pistoia Alliance

With the explosion of interest in both enhanced knowledge management and open science, the past few years have seen considerable discussion about making scientific data “FAIR” — findable, accessible, interoperable, and reusable. The problem is that most scientific datasets are not FAIR. When left to their own devices, scientists do an absolutely terrible job creating the metadata that describe the experimental datasets that make their way in online repositories. The lack of standardization makes it extremely difficult for other investigators to locate relevant datasets, to re-analyse them, and to integrate those datasets with other data. The Center for Expanded Data Annotation and Retrieval (CEDAR) has the goal of enhancing the authoring of experimental metadata to make online datasets more useful to the scientific community. The CEDAR work bench for metadata management will be presented in this webinar. CEDAR illustrates the importance of semantic technology to driving open science. It also demonstrates a means for simplifying access to scientific data sets and enhancing the reuse of the data to drive new discoveries.

CEDAR work bench for metadata management

Pistoia Alliance

Open interoperability standards, tools and services at EMBL-EBI

Pistoia Alliance

Fair webinar, Ted slater: progress towards commercial fair data products and ...

Pistoia Alliance

The FAIR (Findable, Accessible, Interoperable and Reusable) principles aim to maximize the discovery and reuse of digital resources. Using recently developed software and metrics to assess FAIRness and supported through an ELIXIR Implementation Study, Michel worked with a subset of ELIXIR Core Data Resources to apply these technologies. In this webinar, he will discuss their approach, findings, and lessons learned towards the understanding and promotion of the FAIR principles.

Application of recently developed FAIR metrics to the ELIXIR Core Data Resources

Pistoia Alliance

Blockchain technology can revolutionise the way information is exchanged between parties by bringing an unprecedented level of security and trust to these transactions. The technology is finding its way into multiple use cases but we are yet to see full adoption and real-world business implementation in the Healthcare industry. In this webinar we will explore the main challenges and considerations for the implementation of Blockchain technology in Healthcare use cases. This is the third webinar in our Blockchain Education series.

Implementing Blockchain applications in healthcare

Pistoia Alliance

Building trust and accountability - the role User Experience design can play ...

Pistoia Alliance

In the late Fall and Winter of 2018, the Pistoia Alliance in cooperation with Elsevier and charitable organizations Cures within Reach and Mission: Cure ran a datathon aiming to find drugs suitable for treatment of childhood chronic pancreatitis, a rare disease that causes extreme suffering. The datathon resulted in identification of four candidate compounds in a short time frame of just under three months. In this webinar our speakers discuss the technologies that made this leap possible

Pistoia Alliance-Elsevier Datathon

Pistoia Alliance

Data for AI models, the past, the present, the future

Pistoia Alliance

PA webinar on benefits & costs of FAIR implementation in life sciences

Pistoia Alliance

Creating novel drugs is an extraordinarily hard and complex problem. One of the many challenges in drug design is the sheer size of the search space for novel chemical compounds. Scientists need to find molecules that are active toward a biological target or pathway and at the same time have acceptable ADMET properties. There is now considerable research going on using various AI and ML approaches to tackle these challenges. Our distinguished speakers, Drs. Alex Tropsha and Ola Engkvist, will discuss their recent work in Drug Design involving Deep Reinforcement Learning and Neural Networks, and will answer questions from the audience on the current state of the research in the field. Speakers: Prof Alex Tropsha, Professor at University of North Carolina at Chapel Hill, USA Dr. Ola Engkvist, Associate Director at AstraZeneca R&D, Gothenburg, Sweden

AI & ML in Drug Design: Pistoia Alliance CoE

Pistoia Alliance

Ai in drug design webinar 26 feb 2019

Pistoia Alliance

Plus de Pistoia Alliance (20)

Fairification experience clarifying the semantics of data matrices

MPS webinar master deck

Digital webinar master deck final

Heartificial intelligence - claudio-mirti

Fair by design

Knowledge graphs ilaria maresi the hyve 23apr2020

2020.04.07 automated molecular design and the bradshaw platform webinar

Data market evolution, a future shaped by FAIR

AI in translational medicine webinar

CEDAR work bench for metadata management

Open interoperability standards, tools and services at EMBL-EBI

Fair webinar, Ted slater: progress towards commercial fair data products and ...

Application of recently developed FAIR metrics to the ELIXIR Core Data Resources

Implementing Blockchain applications in healthcare

Building trust and accountability - the role User Experience design can play ...

Pistoia Alliance-Elsevier Datathon

Data for AI models, the past, the present, the future

PA webinar on benefits & costs of FAIR implementation in life sciences

AI & ML in Drug Design: Pistoia Alliance CoE

Ai in drug design webinar 26 feb 2019

Dernier

This presentations targets students or working professionals. You may know Google for search, YouTube, Android, Chrome, and Gmail, but did you know Google has many developer tools, platforms & APIs? This comprehensive yet still high-level overview outlines the most impactful tools for where to run your code, store & analyze your data. It will also inspire you as to what's possible. This talk is 50 minutes in length.

Powerful Google developer tools for immediate impact! (2023-24 C)

wesley chun

Advantages of Hiring UIUX Design Service Providers for Your Business

Pixlogix Infotech

Explore 'The Codex of Business: Writing Software for Real-World Solutions,' a compelling SlideShare presentation that delves into digital transformation in healthcare. Discover through a detailed case study how Agile methodologies empower healthcare providers to develop, iterate, and refine digital solutions that address real-world challenges. Learn how strategic planning, user feedback, and continuous improvement drive success in deploying technologies that enhance patient care and operational efficiency. Ideal for healthcare professionals, IT specialists, and digital transformation advocates seeking actionable insights and practical examples of technology making a real difference.

The Codex of Business Writing Software for Real-World Solutions 2.pptx

Malak Abu Hammad

CNv6 Instructor Chapter 6 Quality of Service

giselly40

Enterprise Knowledge’s Urmi Majumder, Principal Data Architecture Consultant, and Fernando Aguilar Islas, Senior Data Science Consultant, presented "Driving Behavioral Change for Information Management through Data-Driven Green Strategy" on March 27, 2024 at Enterprise Data World (EDW) in Orlando, Florida. In this presentation, Urmi and Fernando discussed a case study describing how the information management division in a large supply chain organization drove user behavior change through awareness of the carbon footprint of their duplicated and near-duplicated content, identified via advanced data analytics. Check out their presentation to gain valuable perspectives on utilizing data-driven strategies to influence positive behavioral shifts and support sustainability initiatives within your organization. In this session, participants gained answers to the following questions: - What is a Green Information Management (IM) Strategy, and why should you have one? - How can Artificial Intelligence (AI) and Machine Learning (ML) support your Green IM Strategy through content deduplication? - How can an organization use insights into their data to influence employee behavior for IM? - How can you reap additional benefits from content reduction that go beyond Green IM?

Driving Behavioral Change for Information Management through Data-Driven Gree...

Enterprise Knowledge

Real Time Object Detection Using Open CV

Khem

Tata AIG General Insurance Company - Insurer Innovation Award 2024

The Digital Insurer

Heather Hedden, Senior Consultant at Enterprise Knowledge, presented “The Role of Taxonomy and Ontology in Semantic Layers” at a webinar hosted by Progress Semaphore on April 16, 2024. Taxonomies at their core enable effective tagging and retrieval of content, and combined with ontologies they extend to the management and understanding of related data. There are even greater benefits of taxonomies and ontologies to enhance your enterprise information architecture when applying them to a semantic layer. A survey by DBP-Institute found that enterprises using a semantic layer see their business outcomes improve by four times, while reducing their data and analytics costs. Extending taxonomies to a semantic layer can be a game-changing solution, allowing you to connect information silos, alleviate knowledge gaps, and derive new insights. Hedden, who specializes in taxonomy design and implementation, presented how the value of taxonomies shouldn’t reside in silos but be integrated with ontologies into a semantic layer. Learn about: - The essence and purpose of taxonomies and ontologies in information and knowledge management; - Advantages of semantic layers leveraging organizational taxonomies; and - Components and approaches to creating a semantic layer, including the integration of taxonomies and ontologies

The Role of Taxonomy and Ontology in Semantic Layers - Heather Hedden.pdf

Enterprise Knowledge

Boost Fertility New Invention Ups Success Rates.pdf

sudhanshuwaghmare1

Slack Application Development 101 Slides

praypatel2

A Domino Admins Adventures (Engage 2024)

Gabriella Davis

How to convert PDF to text with Nanonets

naman860154

BooK Now Call us at +918448380779 to hire a gorgeous and seductive call girl for sex. Take a Delhi Escort Service. The help of our escort agency is mostly meant for men who want sexual Indian Escorts In Delhi NCR. It should be noted that any impersonator will get 100 attention from our Young Girls Escorts in Delhi. They will assume the position of reliable allies. VIP Call Girl With Original Photos Book Tonight +918448380779 Our Cheap Price 1 Hour not available 2 Hours 5000 Full Night 8000 TAG: Call Girls in Delhi, Noida, Gurgaon, Ghaziabad, Connaught Place, Greater Kailash Delhi, Lajpat Nagar Delhi, Mayur Vihar Delhi, Chanakyapuri Delhi, New Friends Colony Delhi, Majnu Ka Tilla, Karol Bagh, Malviya Nagar, Saket, Khan Market, Noida Sector 18, Noida Sector 76, Noida Sector 51, Gurgaon Mg Road, Iffco Chowk Gurgaon, Rajiv Chowk Gurgaon All Delhi Ncr Free Home Deliver

08448380779 Call Girls In Diplomatic Enclave Women Seeking Men

Delhi Call girls

Imagine a world where information flows as swiftly as thought itself, making decision-making as fluid as the data driving it. Every moment is critical, and the right tools can significantly boost your organization’s performance. The power of real-time data automation through FME can turn this vision into reality. Aimed at professionals eager to leverage real-time data for enhanced decision-making and efficiency, this webinar will cover the essentials of real-time data and its significance. We’ll explore: FME’s role in real-time event processing, from data intake and analysis to transformation and reporting An overview of leveraging streams vs. automations FME’s impact across various industries highlighted by real-life case studies Live demonstrations on setting up FME workflows for real-time data Practical advice on getting started, best practices, and tips for effective implementation Join us to enhance your skills in real-time data automation with FME, and take your operational capabilities to the next level.

From Event to Action: Accelerate Your Decision Making with Real-Time Automation

Safe Software

With more memory available, system performance of three Dell devices increased, which can translate to a better user experience Conclusion When your system has plenty of RAM to meet your needs, you can efficiently access the applications and data you need to finish projects and to-do lists without sacrificing time and focus. Our test results show that with more memory available, three Dell PCs delivered better performance and took less time to complete the Procyon Office Productivity benchmark. These advantages translate to users being able to complete workflows more quickly and multitask more easily. Whether you need the mobility of the Latitude 5440, the creative capabilities of the Precision 3470, or the high performance of the OptiPlex Tower Plus 7010, configuring your system with more RAM can help keep processes running smoothly, enabling you to do more without compromising performance.

Boost PC performance: How more available memory can improve productivity

Principled Technologies

The presentation explores the development and application of artificial intelligence (AI) from its inception to its current status in the modern world. The term "artificial intelligence" was first coined by John McCarthy in 1956 to describe efforts to develop computer programs capable of performing tasks that typically require human intelligence. This concept was first introduced at a conference held at Dartmouth College, where programs demonstrated capabilities such as playing chess, proving theorems, and interpreting texts. In the early stages, Alan Turing contributed to the field by defining intelligence as the ability of a being to respond to certain questions intelligently, proposing what is now known as the Turing Test to evaluate the presence of intelligent behavior in machines. As the decades progressed, AI evolved significantly. The 1980s focused on machine learning, teaching computers to learn from data, leading to the development of models that could improve their performance based on their experiences. The 1990s and 2000s saw further advances in algorithms and computational power, which allowed for more sophisticated data analysis techniques, including data mining. By the 2010s, the proliferation of big data and the refinement of deep learning techniques enabled AI to become mainstream. Notable milestones included the success of Google's AlphaGo and advancements in autonomous vehicles by companies like Tesla and Waymo. A major theme of the presentation is the application of generative AI, which has been used for tasks such as natural language text generation, translation, and question answering. Generative AI uses large datasets to train models that can then produce new, coherent pieces of text or other media. The presentation also discusses the ethical implications and the need for regulation in AI, highlighting issues such as privacy, bias, and the potential for misuse. These concerns have prompted calls for comprehensive regulations to ensure the safe and equitable use of AI technologies. Artificial intelligence has also played a significant role in healthcare, particularly highlighted during the COVID-19 pandemic, where it was used in drug discovery, vaccine development, and analyzing the spread of the virus. The capabilities of AI in healthcare are vast, ranging from medical diagnostics to personalized medicine, demonstrating the technology's potential to revolutionize fields beyond just technical or consumer applications. In conclusion, AI continues to be a rapidly evolving field with significant implications for various aspects of society. The development from theoretical concepts to real-world applications illustrates both the potential benefits and the challenges that come with integrating advanced technologies into everyday life. The ongoing discussion about AI ethics and regulation underscores the importance of managing these technologies responsibly to maximize their their benefits while minimizing potential harms.

Artificial Intelligence: Facts and Myths

Joaquim Jorge

What are drone anti-jamming systems? The drone anti-jamming systems and anti-spoof technology protect against interference, jamming, and spoofing of the UAVs. To protect their security, countries are beginning to research drone anti-jamming systems, also known as drone strike weapons. The anti-jam and anti-spoof technology protects against interference, jamming and spoofing. A drone strike weapon is a drone attack weapon that can attack and destroy enemy drones. So what is so unique about this amazing system?

What Are The Drone Anti-jamming Systems Technology?

Antenna Manufacturer Coco

The Raspberry Pi 5 was announced on October 2023. This new version of the popular embedded device comes with a new iteration of Broadcom’s VideoCore GPU platform, and was released with a fully open source driver stack, developed by Igalia. The presentation will discuss some of the major changes required to support this new Video Core iteration, the challenges we faced in the process and the solutions we provided in order to deliver conformant OpenGL ES and Vulkan drivers. The talk will also cover the next steps for the open source Raspberry Pi 5 graphics stack. (c) Embedded Open Source Summit 2024 April 16-18, 2024 Seattle, Washington (US) https://events.linuxfoundation.org/embedded-open-source-summit/ https://eoss24.sched.com/event/1aBEx

Raspberry Pi 5: Challenges and Solutions in Bringing up an OpenGL/Vulkan Driv...

Igalia

GenCyber Cyber Security Day Presentation

Michael W. Hawkins

A Call to Action for Generative AI in 2024

Results

Dernier (20)

Powerful Google developer tools for immediate impact! (2023-24 C)

Advantages of Hiring UIUX Design Service Providers for Your Business

The Codex of Business Writing Software for Real-World Solutions 2.pptx

CNv6 Instructor Chapter 6 Quality of Service

Driving Behavioral Change for Information Management through Data-Driven Gree...

Real Time Object Detection Using Open CV

Tata AIG General Insurance Company - Insurer Innovation Award 2024

The Role of Taxonomy and Ontology in Semantic Layers - Heather Hedden.pdf

Boost Fertility New Invention Ups Success Rates.pdf

Slack Application Development 101 Slides

A Domino Admins Adventures (Engage 2024)

How to convert PDF to text with Nanonets

08448380779 Call Girls In Diplomatic Enclave Women Seeking Men

From Event to Action: Accelerate Your Decision Making with Real-Time Automation

Boost PC performance: How more available memory can improve productivity

Artificial Intelligence: Facts and Myths

What Are The Drone Anti-jamming Systems Technology?

Raspberry Pi 5: Challenges and Solutions in Bringing up an OpenGL/Vulkan Driv...

GenCyber Cyber Security Day Presentation

A Call to Action for Generative AI in 2024

Compound Exchange Standards

1. Pistoia Dragon’s Den Restricted Compound List Management 1

2. Business Challenge • Legislation exists at local, national and international levels to restrict the production, import/export, supply, use and possession of certain substances • Pharmaceutical companies must hold multiple licences to conduct research across the field of restricted compounds 2

3. Business Challenge • Legislation is constantly evolving and becoming more complicated as it attempts to mirror developments in substance abuse mephedrone U.S. bans chemicals in "bath salts" street drug methylenedioxypyrovalerone (MDPV) 3

4. Vision for this Project ‘The list’ – a single source of restricted compound knowledge for the pharmaceutical industry – Totally comprehensive in regards to current legislation – Have knowledge of all pending/proposed legislation – keep the pharma industry ‘ahead of the game’ – Have global coverage – it must be possible to check against the restricted compound law in any country/region or check against global legislation – Have complete and correct interpretation of legislation, this interpretation being confirmed by the legislative body concerned – Ideally be ‘certified’ by governments, i.e. use this list and you will be compliant – The list to be provided as required by the industry – Individual Structures (Molfiles, SMILES, INCHI, etc) , Markushes, Compound Names (INN, Trademark, etc), CAS No’s, other identifiers as required, legal status, legal documentation, etc. 4

5. Business Case: Restricted Compounds List • Project cost – $300,000 one-time, plus $100,000 annually • Value Created – Reduce annual cost of $100,000 per company 5

Compound Exchange Standards

Recommandé

Recommandé

Contenu connexe

Plus de Pistoia Alliance

Plus de Pistoia Alliance (20)

Dernier

Dernier (20)

Compound Exchange Standards