Nick Lynch, president of the Pistoia Alliance, delivered this presentation summarizing the mission of the Alliance, its current deliverables and progress, and its strategy for the next several years.

1. Introduction and Strategy Update Nick Lynch, Pistoia Alliance Pistoia Alliance Conference 2011 Boston

2. To do Room check Computer for presenting Roles on the day Registering people Facilitation Beginning and end of sessions lunch & demo End of meeting Questions – picking up questions Ideas board and discussions Twitter tag #pistoiaconf Agenda dry run Present for speakers – Tim Clark Attendee list Wifi? Website up at front during

3. Summary Welcome Thank you to our hosts Thomson Reuters Agenda

4. Please turn off mobiles

5. Questions during the day? John Wise Deb Ausman Nick Lynch Ashley George

6. Feedback Please fill in the feedback form Prize Draw at the end - $50 Amazon voucher

7. Ideas Board Put your ideas for new working groups on the board by the door

8. Host Welcome to Boston Andreas Mattern

10. NATURE Reviews | Drug Discovery Volume 9 | March 2010 10

11. 11

13. NOW

14. Lowering the barriers to innovation by improving inter-operability of R&D business processes through pre competitive collaboration

15. Pistoia Membership March 2011

16. Background—How it all started In Pistoia, Italy Meeting of GSK, AZ, Pfizer and Novartis—identified similar challenges and frustrations in discovery informatics 16

17. Energy Influence Delivery Trust

18. Pistoia Strategy What have we done How do we see the ‘Path to Value’ Pictures

19. Pistoia Strategy

20. Value Common Services Shared Needs

21. Signpost clearly

22. Pistoia Activity Domains Biology/ Translational Research “Understanding Disease” Chemistry Live “Linking Structure with Outcome” Scientific Collaboration

23. Our Approach to Projects…. Sequence Services Vocabulary Standards SESL ELN Query

24. Sequence ServicesWorking Group Slide 24

25. Vocabulary Standards Initiative Slide 25

26. Strategy update Check other slides Break down into domains ‘Path to Value’

27. Networked and Externalised Life Science Research

28. Does Collaboration feel like this?

29. >40%

30. Lack of interoperability

31. delays in knowledge transfer

32. No Science e-Workspace

33. Increased speed of set-up and close-down of business critical collaborations (consumers). Reduced service implementation costs (suppliers) Reduced integration costs (consumers and suppliers). Pictures: Speed, setup and close down Integration costs Lots of wires Hub analogy

34. Scientific Collaboration

35. Science aware collaboration environment working group

36. What is your ambition for Collaboration?

37. Interested? Catch us later

39. Specifically:

40. A workspace that can be created or closed on demand.

41. An extra-enterprise workspace that removes the risks of contamination of internal enterprise data by allowing collaboration data to be managed separately and ownership defined.

42. Provides the ability to facilitate migration of the collaboration data into enterprise systems in a managed and timely manner.

43. The generic tools or platform available (e.g. eRooms or Sharepoint) to facilitate Competitive or Pre-competitive collaborations within the Life Science sector are unable to support the management of scientific information.

44. For Consumers:

45. Lack of interoperability between collaborators internal systems and scientific information leads to delays in knowledge transfer during critical phases of collaboration start-up or close-down.

46. For Providers:

47. Offering less than optimal solutions for scientific data usage in this context of business critical collaborations creates partial solutions with high support costs that have a negative reputational impact .

48. Development of a project team of interested parties.

49. All parties agreed of major outcome is service specification document that includes:

50. Business Requirements

51. Non-functional requirements

52. Functional requirements consisting of:

53. Life Science specialized applications

54. Generic productivity and communication tools

55. Recommendations for any subsequent implementation.

56. Agreed areas of focus for functional requirements for pilot e.g. Ensembl, NGS, Chemistry Sourcing etc.

57. All parties agree components of the specification

58. All parties prepared to submit exemplar data for the specification

59. All parties to review existing standards and make recommendations on their use within this initiative

61. Chair: TBD

62. Steering Committee: all participants investing in the project (money, resources, time).

63. Medium level funding, time/input from members will be critical.

66. Agreed specification document generated by end Q2 2011.

67. Clear picture of feasibility from all stakeholders and >75% of partners interested in a longer term service.

68. Hosted service to improve repeatable low cost delivery.

69. Clarity of data ownership paramount in line with legal strictures of collaboration agreements.

71. Reduced service implementation costs (suppliers)

72. Reduced integration costs (consumers and suppliers).

73. Improved visibility and usability of collaboration information (consumers).

74. Life Science Enabled collaboration environmentsKey Milestones Q3 11 Mar 11 Q2 11 Q1 12 Q4 11 Pilot Planning & Recruitment M Board Approval Resourcing Pilot Kick-off M Execution V1.0 March 2011 Next Phase Scientific Collaboration

75. Collaboration Vision What can’t we do to day What could we do Practical delivery Analogies

76. Chemistry Externalization Processes

77. What next then?

78. www.pistoiaalliance.org If you want to go fast, go alone. If you want to go far, go together.

80. Lunch Arrangement Deliverables from the Sequence Services Phase 1 are available outside Thomson Reuters Infosys Eagle Genomics/Cognizant Constellation/Microsoft

81. Bio IT Talk