The document discusses using the RGD epitope found in engineer "Arg-Gly-Asp" to display on virus-like particles formed from tobacco mosaic virus (TYMV) in order to target cancer cells that up-regulate integrin. It describes mutating the internal scaffold N-terminus of the TYMV coat protein and substituting RGD at residue 44 to create pH-dependent enhanced stability. It also discusses expressing GFP and GUS from dual-subgenomic RNA of TYMV for potential vaccine development and characterizing empty, virion, and intermediate TYMV particles through biophysical studies.