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Metabolic bone disorders overview

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Pramod Mahender
Pramod Mahender
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Metabolic bone disorders Dr Kshitij Srivastava
Metabolic bone disorders ,[object Object],[object Object]
Alterations in mineral ion conc. Regulates hormones and local factors Controls cellular Activity Modulates bone structure and composition The metabolic bone disorders are conditions in which generalized skeletal abnormalities result from disruption of the complex interactive system
Outline ,[object Object],[object Object],[object Object],[object Object]
Normal Bone Structure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Normal Bone Structure ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mineralization Calcification
The cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bone turnover ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Bone turnover ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
BMD, g/cm 2 Age TOTAL BODY Change in BMD (mean ± 1SD) with age in healthy male ( -- ) and female ( -- )
[object Object],[object Object],[object Object],[object Object]
Calcium metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Phosphate metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PTH ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Calcitonin ,[object Object],[object Object],[object Object],[object Object],[object Object]
Vitamin D (cholecalciferol) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Factors affecting bone turnover ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Factors affecting bone turnover ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Factors affecting bone turnover ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bone metabolic disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bone metabolic disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Methods of measuring Bone Mineral Density ,[object Object],[object Object],[object Object],[object Object],[object Object]
Indications for using bone densitometry ,[object Object],[object Object],[object Object]
Biochemical tests ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Metabolic Bone Diseases ,[object Object],[object Object],[object Object],[object Object],[object Object]
Diseases of Mineralization: Osteomalacia and Rickets ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pathophysiology ,[object Object],[object Object],[object Object],[object Object]
Rickets ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Radiological appearances ,[object Object],[object Object],[object Object],[object Object],[object Object]
Biochemistry ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Types of Rickets ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nutritional rickets ,[object Object],[object Object],[object Object],[object Object]
Vitamin D Deficiency ,[object Object],[object Object],[object Object]
Impaired 25(OH)vit D production ,[object Object],[object Object]
Impaired 1,25 (OH) 2 D production ,[object Object],[object Object],[object Object]
Defective vit D receptor (VDR) ,[object Object],[object Object],[object Object]
Hypophosphataemic rickets ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Vitamin D dependent rickets ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Rickets of Prematurity ,[object Object]
Renal rickets(osteodystrophy) ,[object Object],[object Object]
Renal rickets ,[object Object],[object Object],[object Object],[object Object],[object Object]
Drugs and Toxins ,[object Object],[object Object]
Osteoporosis ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Endocrine disorders ,[object Object],[object Object],[object Object],[object Object],[object Object]
Thank You

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Metabolic bone disorders overview

  • 1. Metabolic bone disorders Dr Kshitij Srivastava
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  • 3. Alterations in mineral ion conc. Regulates hormones and local factors Controls cellular Activity Modulates bone structure and composition The metabolic bone disorders are conditions in which generalized skeletal abnormalities result from disruption of the complex interactive system
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  • 15. BMD, g/cm 2 Age TOTAL BODY Change in BMD (mean ± 1SD) with age in healthy male ( -- ) and female ( -- )
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