Innovation in healthcare and wellness is multi-faceted and context sensitive. It is also symbiotic and needs to empower the individual participant at the N-Of-1. This presentation is for my upcoming "Event Chair" keynote at NorCal HIMSS Innovation Conference and Showcase 2018 on Feb 1 at Intel Auditorium in Santa Clara, CA, USA. I will be speaking on applications of emerging technologies - AI, machine & deep learning, advanced analytics, Blockchain - in wellness, medicine, and health sciences.