1. PEDIATRICS SEMINAR PRESENTATIONTOPIC;IRON INTOXICATION IN CHILDREN BY M.S.PRAYTHIESH BRUCE, FINAL MBBS,SMIMS, KULASEKARAM

3. IRON INTOXICATION IN CHILDREN IRON IS A ESSENTIAL NUTRIENT THAT IS COMMON CONTENT OF VITAMIN PREPARATIONS AND TONICS IRON POISONING IS A PEDIATRIC EMERGENCY ONE OF THE TOP 10 SUBSTANCES INGESTED BY CHILDREN LESS THAN 5 YEARS CHRONIC IRON INTOXICATION OCCUR DUE TO REPEATED BLOOD TRANSFUSION AND THALASSEMMIA

4. ACCIDENTAL POISONING OF IRON IN CHILDREN OCCUR DUE TO ; FREQUENT IRON SUPPLEMENTS FOUND IN MANY HOMES UNAWARENESS OF PEOPLE THAT IRON CAN BE DANGEROUS ATTRACTIVENESS OF IRON TABLETS ILLETERACY AND CARELESSNESS OF PATIENT

5. PATHOPHYSIOLOGY OF IRON POISONING

6. TOXIC DOSES LOWEST LETHAL DOSE OF IRON IS 600MG 20MG/KG SUB TOXIC 20-60MG/KGBODY WEIGHT –MILD SYMPTOMS >60MG/KG BODY WEIGHT-POTENTIALLY LETHAL

7. CLINICAL FEATURES VOMITING,ABDOMINAL PAIN CRAMPS,HEMATEMESIS,DIARRHOEA,CIRCULATORY FAILURE,JAUNDICE(2-4 DAYS LATER)

8. CLINICAL FEATURES OF IRON I INTOXICATION GASTROINTESTINAL STAGE;30MIN-2HOURS APPARENT RECOVERY;2-6HOURS CIRCULATORY FAILURE;12 HOURS HEPATIC NECROSIS;2-4 DAYS GASTRIC SCARRING-2-4 WEEKS

9. DEFINITIVE TREATMENT OF IRON INTOXICATION CHELATING AGENT;DESFERRIOXAMINE INDICATIONS; LETHARGHY,TACHYPNEA,TACHYCARDIA HYPOTONIA FREE SERUM IRON IS MORE THAN 50UG/DL TOTAL SERUM IRON >350UG/DL LEUCOCYTE COUNT MORE THAN 15,000CUMM SERUM GLUCOSE>150MG/DL

10. ROUTE AND DOSAGE OF DESFERRIOXAMINE . . ACUTE CASES IV INFUSION LESS SEVERE CASES IM I5MG/KG/HR IV AND 50MG/KG GIVEN EVERY 4 HOURS IM TOTAL DOSE SHOULD NOT EXCEED 6GM IV OR IM PREPARATION AVAILABLE;POWDER FORM IN VIAL 5OOMG WHICH DILATED IN WATER FOR INJECTION TO HAVE 10 %SOLUTION SOLUTION IS DILUTED IN 0.8%SALINE IN 5%DEXTROSE FOR CONTINOUS IV ADMINISTRATION

11. INVESTIGATIONS; PLAIN XRAY OF ABDOMEN FREE SERUM IRON>50MG/DL TOTAL SERUM IRON>350MG/DL LEUCOCYTOSIS

12. MANAGEMENT OF IRON INTOXICATION IN CHILDREN EMESIS WITH SYRUP IPECAC GASTRIC LAVAGE SUPPORTIVE AND SYMPTOMATIC TREATMENT CHELATION THERAPHY DIALYSIS WITH CHELATION VERY SEVERE CASES ;EXCHANGE TRANSFUSION CHARCOAL HEMOPERFUSION WITH SIMULTANEOUS CHELATION

13. THANK YOU