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4Q10 and 2010 Earnings Release
                   March, 3rd, 2011
Highlights in the Period

• A drop of 3.7 days in the Company's cash cycle when compared with 2009 (IFRS base), to 49.0 days. This is the
shortest cash cycle since 2006. This decrease resulted in a fall of about R$ 22.9 million in working capital;

• The operating cash flow was positive for the third consecutive year and amounted to R$ 44.4 million, or 1.7% of the
net operating revenue;

• The net debt stood at R$ 108.7 million in December 2010, a R$ 9.4 million decrease in relation to December 2009,
mainly due to the Company's positive operating cash generation, of about R$ 44.4 million;

• A rise of 3.0% in consolidated gross revenues year-over-year, totaling R$ 3.1 billion, highlighting the health and
beauty category, in which a sharp growth of 37.8% was recorded;

• Sales through electronic orders hit a record high and accounted for 65.3% of total sales in 2010;

• In October 2010, Profarma decided to terminate the market maker contract with Credit Suisse Brasil SA CTVM;
nevertheless, there was no drop in daily liquidity.




                                                                                                                        3
Gross Revenues Evolution
                    (R$ Million)



                                              3,132.8
                                   3,041.6




807.4   809.8         832.3




4Q09    3Q10          4Q10             2009    2010




                                                        4
Gross Revenues Breakdown

(R$ Million)                 4Q10    4Q09    Chg. %   3Q10    Chg. %     2010      2009    Chg. %

Branded                      554.6   546.3    1.5%    537.8   3.1%     2,083.4   2,058.5   1.2%
Generic                       59.6    50.8   17.5%     56.2   6.1%      219.5     165.1    32.9%
OTC                          151.4   157.1   -3.6%    153.7   -1.5%     590.8     602.0    -1.9%
Health and Beauty Products    43.9    26.2   67.3%     38.6   13.7%     142.3     103.2    37.8%
Hospitals and Vaccines        22.7    27.1   -16.3%    23.5   -3.6%      96.6     112.7    -14.3%

Total                        832.3   807.4    3.1%    809.8   2.8%     3,132.8   3,041.6   3.0%




                                                                                                    5
Market Share Evolution (%)



                            11.5   11.7                                11.6*
                                              10.9*
                                                          10.2*                10.2*   10.4*
        9.6




       2006                 2007   2008       2009        2010         4Q09    3Q10    4Q10

*Excluding the similar’s effect                                                        Source: IMS




                                                                                                     6
Gross Profit and Revenues from Services to Suppliers
                             (R$ million and as % Net Revenues)


                                                                  11.7%
11.0%
                                                                                         10.7%
                      10.2%               10.1%
                                                                  37.9

                                                                                         100.3




                                                                                         181.1
                                                                  263.6

18.6
                      26.8                 28.4
57.1                  43.3                 41.7

4Q09                  3Q10                 4Q10                   2009                   2010

       Gross Profit     Revenues from Services to Suppliers               Gross Profit Margin(%)




                                                                                                   7
Operating Expenses
               (R$ million and as % Net Revenues)



 7.4%                         7.4%                   7.5%    7.7%
        7.1%

                                                            202.0
                                                    193.9




50.6    48.6                 51.5




4Q09    3Q10                 4Q10                   2009    2010




                                                                    8
Ebitda and Ebitda Margin
              (R$ million and as % Net Revenues)


4.1%                                                4.3%

       3.1%                                                3.0%
                             2.7%                  110.7



                                                           79.9




28.0
       21.5                  18.6




4Q09   3Q10                 4Q10                   2009    2010




                                                                  9
Net Financial Expenses
              (R$ million and as % Net Revenues)



                                                          1.1%
                                                   1.0%
                             0.9%
0.8%   0.8%
                                                          28.5
                                                   26.7




5.3    5.4                   6.0




4Q09   3Q10                 4Q10                   2009   2010




                                                                 10
Net Profit
              (R$ million and as % Net Revenues)



2.2%                                               2.1%
                             1.5%                         1.3%
       0.7%
                                                   53.2




                                                          34.4




15.4
                            10.5
       4.7



4Q09   3Q10                 4Q10                   2009   2010




                                                                 11
CASH FLOW

(R$ Million)                                           4Q10     4Q09     Chg. %    3Q10     Chg %     2010     2009     Chg. %

Cash Flow Generated / (Used) in Operating Activities   (21.3)   (19.2)   -11.0%    62.1       -       44.4     80.2     -44.7%
  Internal Cash Generation                             22.2     23.7      -6.1%     9.5     134.4%    67.9     92.5     -26.6%
  Operating Assets Variation                           (43.5)   (42.9)    -1.5%    52.7       -       (23.5)   (12.3)   -91.4%
     Trade Accounts Receivable                         (16.4)   (25.1)   34.5%     (50.8)   67.7%     (40.6)   (8.6)    -371.2%
     Inventories                                       (88.0)   (81.8)    -7.5%    (10.4)   -742.5%   (1.2)    (35.0)   96.6%
     Suppliers                                         118.2    91.3     29.5%     120.6     -2.0%    45.1     80.8     -44.1%
     Other Items                                       (57.4)   (27.3)   -109.9%   (6.8)    -749.1%   (26.8)   (49.4)   45.8%

Cash Flow (Used) in Investing Activities               (3.3)    (3.6)     7.5%     (1.5)    -122.0%   (8.1)    (11.8)   30.9%

Cash Flow Generated / (Used) by Financing Activities   (15.5)   (9.9)    -56.8%    (43.8)   64.6%     (43.8)   (94.3)   53.5%

Net Increase / (Decrease) in Cash                      (40.1)   (32.6)   -22.8%    16.9       -       (7.5)    (25.8)   70.8%




                                                                                                                                  12
Cycle Previous IFRS                                                           Cycle IFRS Basis

                                      4Q08 4Q09 3Q10 4Q10                                                          4Q08 4Q09 3Q10 4Q10
      Cash Cycle (Days) *              65.8     52.7    48.8    49.0                Cash Cycle (Days) *            66.0    52.7   48.8   49.0

  Accounts Receivable(1)               45.9     41.1    43.3    43.6         Accounts Receivable (1)                45.9   41.1   43.3   43.6
  Inventories (2)                      49.9     49.6    40.6    48.7         Inventories (2)                       53.6    53.9   43.9   52.0
  Accounts Payable (3)                 29.9     38.0    35.1    43.3         Accounts Payable (3)                  33.5    42.3   38.4   46.6

* Average:
(1) Average of Gross Revenues in the Quarter   (2) Average of COGS in the Quarter    (3) Average of COGS in the Quarter




                                                                                                                                                13
Indebtedness: Net Debt and Net Debt / Ebitda*
                                          (R$ million)



                                              1.4x                       1.4x
          1.1x                                               1.1x
                                 0.8x

         118.1                                              118.1
                                            108.7                       108.7



                                75.1




         4Q09                   3Q10         4Q10           2009        2010

* Ebitda = Accumulated last 12 months




                                                                                14
Capex
              (R$ million and % as Net Revenues)



0.5%                         0.5%                  0.5%
                                                          0.3%
       0.2%

                                                   12.0


                                                          8.3




3.7                          3.5

       1.5




4Q09   3Q10                 4Q10                   2009   2010




                                                                 15
Operating Indicators

                Service Level                                        Logistics E.P.M.
        (Units served/ Units requested)                              (Errors per Million)



93.0%                                                                                       170.0

                    90.4%
                                                             130.0
                                          88.1%
                                                                         93.0




4Q09                3Q10                  4Q10                4Q09        3Q10              4Q10




                                                                                                    16
Profarma vs Ibovespa -% year 2010
120




110




100
                                                                                                                                                    101


                                                                                                                                                    95

90




       * Base 100 em 30/12/2009
80
  Jan-10
30-dez-09    Feb-10
            29-jan-10    Mar-10
                        28-fev-10    Apr-10    May-10
                                    30-mar-10 29-abr-10    Jun-10
                                                          29-mai-10    Jul-10
                                                                      28-jun-10    Aug-10
                                                                                  28-jul-10    Sep-10
                                                                                              27-ago-10    Oct-10
                                                                                                          26-set-10    Nov-10
                                                                                                                      26-out-10    Dec-10    Jan-11
                                                                                                                                  25-nov-10 25-dez-10

                                                            Ibovespa                  Profarma




                                                                                                                                                          17
Analyst Coverage

Company          Analyst                              Telephone           E-mail

                 Javier Martinez de Olcoz Cerdan      (1 212) 761-4542    javier.martinez.olcoz@morganstanley.com
Morgan Stanley
                 Clarissa Berman                      (55 11) 3048-6214   clarissa.berman@morganstanley.com


Merrill Lynch    Alexandre Pizano                     (55 11) 2188-4024   alexandre.pizano@baml.com


Credit Suisse    Marcel Moraes                        (55 11) 3841-6302   marcel.moraes@credit-suisse.com


                 Juliana Rozenbaum                    (55 11) 3073-3035   juliana.rozenbaum@itausecurities.com
Itaú BBA
                 Marcio Osako                         (55 11) 3073-3040   marcio.osako@itausecurities.com


Banco Fator      Iago Whately                         (55 11) 3049-9480   iwhately@bancofator.com.br


Raymond James    Guilherme Assis                      (55 11) 3513-8706   guilherme.assis@raymondjames.com


BTG Pactual      João Carlos dos Santos               (55 11) 3383-2384   joaocarlos.santos@btgpactual.com




                                                                                                                    18
Profarma 4Q10

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Profarma 4Q10

  • 1.
  • 2. 4Q10 and 2010 Earnings Release March, 3rd, 2011
  • 3. Highlights in the Period • A drop of 3.7 days in the Company's cash cycle when compared with 2009 (IFRS base), to 49.0 days. This is the shortest cash cycle since 2006. This decrease resulted in a fall of about R$ 22.9 million in working capital; • The operating cash flow was positive for the third consecutive year and amounted to R$ 44.4 million, or 1.7% of the net operating revenue; • The net debt stood at R$ 108.7 million in December 2010, a R$ 9.4 million decrease in relation to December 2009, mainly due to the Company's positive operating cash generation, of about R$ 44.4 million; • A rise of 3.0% in consolidated gross revenues year-over-year, totaling R$ 3.1 billion, highlighting the health and beauty category, in which a sharp growth of 37.8% was recorded; • Sales through electronic orders hit a record high and accounted for 65.3% of total sales in 2010; • In October 2010, Profarma decided to terminate the market maker contract with Credit Suisse Brasil SA CTVM; nevertheless, there was no drop in daily liquidity. 3
  • 4. Gross Revenues Evolution (R$ Million) 3,132.8 3,041.6 807.4 809.8 832.3 4Q09 3Q10 4Q10 2009 2010 4
  • 5. Gross Revenues Breakdown (R$ Million) 4Q10 4Q09 Chg. % 3Q10 Chg. % 2010 2009 Chg. % Branded 554.6 546.3 1.5% 537.8 3.1% 2,083.4 2,058.5 1.2% Generic 59.6 50.8 17.5% 56.2 6.1% 219.5 165.1 32.9% OTC 151.4 157.1 -3.6% 153.7 -1.5% 590.8 602.0 -1.9% Health and Beauty Products 43.9 26.2 67.3% 38.6 13.7% 142.3 103.2 37.8% Hospitals and Vaccines 22.7 27.1 -16.3% 23.5 -3.6% 96.6 112.7 -14.3% Total 832.3 807.4 3.1% 809.8 2.8% 3,132.8 3,041.6 3.0% 5
  • 6. Market Share Evolution (%) 11.5 11.7 11.6* 10.9* 10.2* 10.2* 10.4* 9.6 2006 2007 2008 2009 2010 4Q09 3Q10 4Q10 *Excluding the similar’s effect Source: IMS 6
  • 7. Gross Profit and Revenues from Services to Suppliers (R$ million and as % Net Revenues) 11.7% 11.0% 10.7% 10.2% 10.1% 37.9 100.3 181.1 263.6 18.6 26.8 28.4 57.1 43.3 41.7 4Q09 3Q10 4Q10 2009 2010 Gross Profit Revenues from Services to Suppliers Gross Profit Margin(%) 7
  • 8. Operating Expenses (R$ million and as % Net Revenues) 7.4% 7.4% 7.5% 7.7% 7.1% 202.0 193.9 50.6 48.6 51.5 4Q09 3Q10 4Q10 2009 2010 8
  • 9. Ebitda and Ebitda Margin (R$ million and as % Net Revenues) 4.1% 4.3% 3.1% 3.0% 2.7% 110.7 79.9 28.0 21.5 18.6 4Q09 3Q10 4Q10 2009 2010 9
  • 10. Net Financial Expenses (R$ million and as % Net Revenues) 1.1% 1.0% 0.9% 0.8% 0.8% 28.5 26.7 5.3 5.4 6.0 4Q09 3Q10 4Q10 2009 2010 10
  • 11. Net Profit (R$ million and as % Net Revenues) 2.2% 2.1% 1.5% 1.3% 0.7% 53.2 34.4 15.4 10.5 4.7 4Q09 3Q10 4Q10 2009 2010 11
  • 12. CASH FLOW (R$ Million) 4Q10 4Q09 Chg. % 3Q10 Chg % 2010 2009 Chg. % Cash Flow Generated / (Used) in Operating Activities (21.3) (19.2) -11.0% 62.1 - 44.4 80.2 -44.7% Internal Cash Generation 22.2 23.7 -6.1% 9.5 134.4% 67.9 92.5 -26.6% Operating Assets Variation (43.5) (42.9) -1.5% 52.7 - (23.5) (12.3) -91.4% Trade Accounts Receivable (16.4) (25.1) 34.5% (50.8) 67.7% (40.6) (8.6) -371.2% Inventories (88.0) (81.8) -7.5% (10.4) -742.5% (1.2) (35.0) 96.6% Suppliers 118.2 91.3 29.5% 120.6 -2.0% 45.1 80.8 -44.1% Other Items (57.4) (27.3) -109.9% (6.8) -749.1% (26.8) (49.4) 45.8% Cash Flow (Used) in Investing Activities (3.3) (3.6) 7.5% (1.5) -122.0% (8.1) (11.8) 30.9% Cash Flow Generated / (Used) by Financing Activities (15.5) (9.9) -56.8% (43.8) 64.6% (43.8) (94.3) 53.5% Net Increase / (Decrease) in Cash (40.1) (32.6) -22.8% 16.9 - (7.5) (25.8) 70.8% 12
  • 13. Cycle Previous IFRS Cycle IFRS Basis 4Q08 4Q09 3Q10 4Q10 4Q08 4Q09 3Q10 4Q10 Cash Cycle (Days) * 65.8 52.7 48.8 49.0 Cash Cycle (Days) * 66.0 52.7 48.8 49.0 Accounts Receivable(1) 45.9 41.1 43.3 43.6 Accounts Receivable (1) 45.9 41.1 43.3 43.6 Inventories (2) 49.9 49.6 40.6 48.7 Inventories (2) 53.6 53.9 43.9 52.0 Accounts Payable (3) 29.9 38.0 35.1 43.3 Accounts Payable (3) 33.5 42.3 38.4 46.6 * Average: (1) Average of Gross Revenues in the Quarter (2) Average of COGS in the Quarter (3) Average of COGS in the Quarter 13
  • 14. Indebtedness: Net Debt and Net Debt / Ebitda* (R$ million) 1.4x 1.4x 1.1x 1.1x 0.8x 118.1 118.1 108.7 108.7 75.1 4Q09 3Q10 4Q10 2009 2010 * Ebitda = Accumulated last 12 months 14
  • 15. Capex (R$ million and % as Net Revenues) 0.5% 0.5% 0.5% 0.3% 0.2% 12.0 8.3 3.7 3.5 1.5 4Q09 3Q10 4Q10 2009 2010 15
  • 16. Operating Indicators Service Level Logistics E.P.M. (Units served/ Units requested) (Errors per Million) 93.0% 170.0 90.4% 130.0 88.1% 93.0 4Q09 3Q10 4Q10 4Q09 3Q10 4Q10 16
  • 17. Profarma vs Ibovespa -% year 2010 120 110 100 101 95 90 * Base 100 em 30/12/2009 80 Jan-10 30-dez-09 Feb-10 29-jan-10 Mar-10 28-fev-10 Apr-10 May-10 30-mar-10 29-abr-10 Jun-10 29-mai-10 Jul-10 28-jun-10 Aug-10 28-jul-10 Sep-10 27-ago-10 Oct-10 26-set-10 Nov-10 26-out-10 Dec-10 Jan-11 25-nov-10 25-dez-10 Ibovespa Profarma 17
  • 18. Analyst Coverage Company Analyst Telephone E-mail Javier Martinez de Olcoz Cerdan (1 212) 761-4542 javier.martinez.olcoz@morganstanley.com Morgan Stanley Clarissa Berman (55 11) 3048-6214 clarissa.berman@morganstanley.com Merrill Lynch Alexandre Pizano (55 11) 2188-4024 alexandre.pizano@baml.com Credit Suisse Marcel Moraes (55 11) 3841-6302 marcel.moraes@credit-suisse.com Juliana Rozenbaum (55 11) 3073-3035 juliana.rozenbaum@itausecurities.com Itaú BBA Marcio Osako (55 11) 3073-3040 marcio.osako@itausecurities.com Banco Fator Iago Whately (55 11) 3049-9480 iwhately@bancofator.com.br Raymond James Guilherme Assis (55 11) 3513-8706 guilherme.assis@raymondjames.com BTG Pactual João Carlos dos Santos (55 11) 3383-2384 joaocarlos.santos@btgpactual.com 18