It concludes that although fractionalised CO2 laser resurfacing is recognised as the gold standard procedure for tissue that has lost its elasticityit has adverse risks and does not adequately address the problems associated with chronological aging. He addresses the requirement to apply adjunct methods such as plasma rich platelets to address nasolabial or marionette lines and volume deficits resulting from the loss and repositioning of facial fat. It establishes the benefit of using other facial rejuvenating therapies including microneedling, PRP growth factors, 633 nm light to limit the depth of laser penetration and decrease the risk of scarring and permanent pigmentary alteration. The novel technique is called the DUBLiN facelift as an acronym of the procedures involved: Dermaroller, UltraPulse laser, Blood growth factors, Light (near-red 633 nm), and Neurotoxin.
7. PIGMENTATION
PIGMENTATION
FINE
RHYTIDS
Positive
FAT
FAT
PROTRUSION
PROTRUSION Title
CO2 COARSE
COARSE
RYTHIDS
RYTHIDS
FRSL
SALLOW SKIN THREAD VEINS
THREAD VEINS
8. Patient CM 2 passes under R eye with obvious reduction in rhytides and neocollogenesis
9.
10. Volume loss
Volume loss
Cheek
Augmentation
Negative
Marionette
Marionette
Lines
Lines Title
CO2
FRSL
Nasolabial
Nasolabial
Lines
Lines
Eyebrow Height Youthful Look
Youthful Look
11. Botox
CO2 Laser Although, many feel that
ultrapulsed fractionalised
CO2 laser skin resurfacing is
the best treatment option for
photo aged facial skin, could
we improve on this modality.
Fibroblast
Stimulation
New Collagen
12. The DUBLiN method uses different
methods and technologies in order
to activate fibroblasts and direct
them towards neocollogenesis. It
also uses low level pulsed lasers to
reduce skin laxity, accelerate growth
factors and cause tightening.
13. The DUBLiN method incorporates
D Dermaroller
U Ultrapulse Laser
B Blood Factors
Li Light – 633nm
N Neurotoxin
14. Induction of FIBROBLASTS
A fibroblast is a type of cell that
synthesizes the extracellular matrix
and collagen, the structural
framework (stroma) for animal
tissues, and plays a critical role in
wound healing. Fibroblasts are the
most common cells of connective
tissue in animals.
15. Comparative study over three months
• Over 3 months, 15 patients
(Group 1) received FLSR
at normal settings
• Results were compared to
29 patients (Group 2)
received low energy FLRS
+ adjunctive treatments
• Both group received BTXA
one week prior to other
treatments
16. Group 2 received a 3-phase combination
multi-rejuvenation technique over 3 weeks.
• Phase I included Dysport® at dilution
3.5:1 in 3 areas
• Phase 2 introduced intense fibroblast
stimulation and modification through
microneedling, PRP growth factor
induction and near-red phototherapy.
• Phase 3 included low–level (CO2)
Ultrapulse laser with settings (Energy)
100 mJ (Rate) 14w CPG 3/5/2 and
adjunct near-red 633nm
phototherapy.
17. PHASE 2 multi-combination
technique
PRP Growth Factor Signals
Fibroblast
Title
Generation
Dermaroller
Dermaroller
Near Red Light 633
Near Red Light 633
18. PHASE 2a fibroblast activation
PRP Growth Factor Signals
Fibroblast
Title
Activation
Dermaroller
Dermaroller
Near Red Light 633
Near Red Light 633
19. PHASE 2b fibroblast stimulation
PRP Growth Factor Signals
Fibroblast
Title
Stimulation
Dermaroller
Dermaroller
Near Red Light 633
Near Red Light 633
22. GROWTH FACTORS
The efficacy of certain growth
factors in forming collagen and
healing various injuries is the
theoretical basis for the use of PRP
in tissue repair. The platelets
collected in PRP are activated by
the addition of thrombin and calcium
chloride. This induces the release of
these factors from alpha granules
23. LiGHT 633nm
Migrating cells exert forces
against the substrate to
move forward. These forces
are part of the contraction
phase of migration in which
the rear of the cell is
detached from the substrate
and the body of the cell is
moved forward.
24. PHASE 2
Co2 Laser
Collagen
Title
Synthesis
Post NTa
Post NTa
Near Red Light 633
Near Red Light 633
25. ULTRALASE LASER
Laser specialists non-sequential
fractionalised CO2 laser ablation
is the most effective modality for
repairing photo damaged skin
The benefits are more precise
control of ablation depth, faster
recovery time and reduced risk of
post procedural problems
26.
27. WSRS = Wrinkle Severity Rating Scale
5 Extreme Extremely deep and long folds, detrimental to facial appearance.
2-4mm Visible V-shaped fold when stretched
Unlikely to have satisfactory correction with injectable implant alone.
4 Severe Very long and deep folds; prominent facial feature.
Less than 2mm visible fold when stretched.
Significant improvement is expected from injectable implant.
Moderately deep folds.
3 Moderate Clear facial feature visible at normal appearance but not when stretched.
Excellent correction is expected from injectable implant.
Shallow but visible fold with a slight indentation; minor facial feature.
2 Mild Implant is expected to produce a slight improvement in appearance.
1 Absent No visible fold, continuous skin line.
28. GAIS = Global Aesthetic Improvement Scale
5 Very Much Improved Optimal cosmetic result for the implant in this
patient.
4 Much Improved Marked improvement in appearance but not
completely optimal for this patient. A touch-up
would slightly improve the result.
3 Improved Obvious improvement in appearance from the initial
condition, but a touch-up or re-treatment is
indicated.
2 No Change The appearance is essentially the same as the
original condition.
1 Worse The appearance is worse than the original
condition.