workshop cnr isof_r2b

GRAPHENE RESEARCH@ ISOF

Graphene = a single layer of carbon atoms, arranged in
honeycomb lattice, forming a perfect, completely aromatic
network.

• Highly stable
• Very good mechanical properties
• High thermal and electrical conductivity
• Excellent stability in air.

The nanochemistry group at ISOF works on the
production of graphene by chemical exfoliation, its
chemical functionalization through covalent or
supramolecular interactions, and its characterization at
nanometric scale.

R2B, BOLOGNA, 8-9 GIUGNO 2011

GRAPHENE OXIDE

• Can be produced in large scale.

• Highly soluble in water and in some organic
solvents.

• Present in solution as monoatomic single sheets.

• Sheet size can be tuned from 1 um to 100 um.

• Can be chemically functionalized.


Size control on 2 orders of magnitude (1-100 um)

4.8 um 60 um
Height Histogram
Height Profile


Uniform, deposition on large areas (> 100 um) on
any given substrate


Deposition on any given substrate
(by finding the right conditions)
Silicon

Quartz

Glass


All monolayers up to 45% surface coverage

Coverage evolution Thickness evolution


Visualizing graphene sheets by fluorescence quenching
OM image

100 µm

Fluorescence image

100 µm
Treossi, E., et al., JACS 2009, 131, 15576.

Covalent functionalization of graphene sheets
with optically active oligothiophenes.

500
nm

Melucci, M., et al., Journal of Materials Chemistry 2010, 20, 9052.

p-type µ = 1 cm2/Vs
n-type µ = 0.2 cm2/Vs


Nanoscopic monitoring of GO reduction
Current mapping High

AFM C-AFM

Low

e-

Potential decay mapping
High

∇-AFM KPFM

VD =
Low
1V

2 µm 2 µm


Kelvin Probe Force Microscopy

AFM

• Maps the electric potential
with resolution of few nm
and few mV.
• Contactless, minimal
perturbation of sample
KPFM potential.
• Can be performed on
working devices (transistors,
photovoltaic blends)

Review paper: Palermo, V., et al., Advanced Materials, (2006) 18, 145.
Liscio, A., et al., Accounts of Chemical Research, 2010

Self-assembly from nano- to macro-scale

Coronenes

1µm 1 µm
ORIGINAL SVA= 18 hours 50
µm

Perylenes

soluble
fullerenes
(PCBM ) 150 x 125 µm


Depositing organic semiconductors on graphene
pyrene

topography Potential, KPFM

Z range = 5 nm Z range = 150 mV

Pyrene RGO
nanocrystals Single sheet

Improved charge mobility in Polythiophene-RGO FET
SOURCE

DRAIN
P3HT

Selective improvement of hole
mobility

Charge mobility/graphene coverage

ION/IOFF ratio ∼
105


Design
and
synthesis
of
mul2func2onal

π-‐conjugated
organic
and
hybrid
materials

Manuela
Melucci,
Laura
Favare/o,
Massimo
Zambianchi


π-‐Conjugated
Materials

Proper8es:
Fluorescence,
Charge
transport,
Self-‐assembly…..

Applica8ons:
organic
electronics
(FET,
LED,
PVD,
oLET),
nano(bio)technology
(sensing,

imaging)


From
molecular
to
complex
hybrid
materials

Sustainable

chemistry

Property-‐speciﬁc
design
and
synthesis
of……
Molecular
materials

20
µm
50
µm

SiO2
SiC

graphene
NPs
Nanowires

(Bio)
Polymers
Hybrid
1D,
2D,
3D
(nano)materials


MOLECULAR
MATERIALS
FOR
ORGANIC
DEVICES

Liquid
crystals

Thin
ﬁlm
transistor

Crystals,ﬁbers,
helics
and
more…………..


Engineered
biopolymers
for
photovoltaics:

renewable
materials
for

a
renewable
energy
technology


Mul2color
dye-‐doped
silica
nanopar2cles
for
bioimaging

30 nm

MW

Chemosensors

surface

anchoring

Mul2color
emission
by
N-‐complexa2on

pH
7

pH
1

20
µm

pH
5
pH
4
pH
1
pH
7

Op2cal

devices
for
pH/
ca2on
sensing


MDSD LAB
Molecular design synthesis and delivery Laboratory

http://mdsdlab.bo.cnr.it

Via Gobetti 101 40129 Bologna Tel. 051 639 8283 Fax. 051 639 8349


NANOPARTICELLE POLIMERICHE PER APPLICAZIONI BIOLOGICHE

Hydroquinone, O
O + Br
N N 5
7 50°C; 24h
O O Br
(1)

H2O, N2, 300 rpm, 80°C

methylmethacrylate, N
15 min; AIBA, 4h Br



AcO O OH
Ph

O NH O
O
H
Ph O OAc
Na+ OH O
O O O
Ph

NaO3S 11

O
N
N
O

N N O O
+Na-O S N
3
O
13



CORE di PMMA
co-polimerizzato con
Fluorofori



APPARATI EXTRA-CORPOREI PER LA RIMOZIONE DELLA EPARINA E
DELLE CITOCHINE INFIAMMATORIE


SCAFFOLDS MOLECOLARI CON ATTIVITA’ BIOLOGICA


SCAFFOLDS MOLECOLARI CON ATTIVITA’ BIOLOGICA

PROGETTAZIONE - SINTESI - ANALISI PRECLINICA

TUMORE ALLA PROSTATA IN FASE AVANZATA/RESISTENTE

TERAPIA ORMONALE SOSTITUTIVA (andropausa, calo della libido,
depressione, osteoporosi da glucocorticoidi e da postmenopausa)

ANABOLIZZANTI NELLA CACHESSIA NEOPLASTICA

SINDROME DI KENNEDY


TUMORE ALLA PROSTATA

  Stati Uniti 70/100.000   Origine etnica
  Età
  Europa 40/100.000
  Storia familiare
  Dieta
  Asia 3-4/100.000

Nat
Rev
Cancer,
(2001)


ANDROPAUSA

LA PERCENTUALE DI SOGGETTI CON BASSI LIVELLI DI TESTOSTERONE AUMENTA CON L’ETA’

Eﬀetti negativi dell abuso di androgeni

-  blocco transitorio della spermatogenesi ed infertilità
-  ipertro a prostatica > carcinoma prostata
-  sleep-apnea
-  obesità viscerale
-  dislipidemia ed aterosclerosi
-  poliglobulia
-  epatotossicità > epatomi

MODULATORI SELETTIVI DI AR: NUOVA GENERAZIONE

WO/2010/092546: Androgen Receptor Modulating Coumponds, Preparation and
uses Thereof

WO/2010/116342: Non-Steroidal Compounds for Androgen Receptor
Modulation, Processes for the Preparation and Uses Thereof

Applicants: CONSIGLIO NAZIONALE DELLE RICERCHE, Dipartimento di
Progettazione Molecolare
ISTITUTO SCIENTIFICO ROMAGNOLO PER LO STUDIO E LA CURA DEI TUMORI
(I.R.S.T.) S.R.L.

Inventors: Greta Varchi, Andrea Guerrini, Anna Tesei, Giovanni Brigliadori.


workshop cnr isof_r2b

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