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Dots plus and childhood tb
1. DR RAGHURAM V, MD
PROFESSOR AND HEAD
DEPT OF COMMUNITY MEDICINE
DOTS-PLUS
2. INTRODUCTION
It is a regimen included under RNTCP
programme for treating cases of drug resistant TB
Involves use of second line anti-tubercular drugs
Duration of treatment longer.
6. DOTS –PLUS REGIMEN
The regimen should usually comprise 6 drugs
Pyrazinamide, Ethambutol, a later generation
Fluoroquinolone (such as high dose Levofloxacin)
and a parenteral agent (such as Kanamycin or
Amikacin), Ethionamide (or Prothionamide), and
either Cycloserine or PAS (P-aminosalicyclic
acid), if Cycloserine cannot be used.
7. CONTD..
This regimen should be used during six to nine
months of the intensive phase.
Four drugs usually Levoflaxacin, Ethionamide,
Ethambutol and Cycloserine, should be used
during the 18 months of the continuation phase.
8.
9. CHILDHOOD TB
Prevalence of the disease in India
15-25 per 1000 population
15 million infected, 25% sputum positive
3 to 4 million infected are children
10. Portal of entry for tuberculosis
Inhalation of Tubercle bacilli in >95% (M.TB)
Ingestion of milk containing Bovine Tubercle
bacilli (M. bovis)
Contamination of superficial skin or mucous
membrane lesion with tubercle bacilli
Congenital infection when mother has
lymphohematogenous spread during
pregnancy
11. Primary infection- Children vs. Adults
Adult primary infection tends to be more local and
pulmonary.
In children the disease tends to be more
disseminated .
12. Symptoms of childhood
tuberculosis
Failure to thrive } &
Intermittent fever } are the commonest symptoms
Pleural effusion
Ascites
Abdominal mass (Painless)
Limp / Arthritis
Painless lymphadenopathy
Persistent skin ulcer
Sterile pyuria
Meningitis
13. Diagnosis of TB
Z-N staining
AFB culture on L-J Medium
PCR amplification of targeted mycobacterial DNA
sequences
BACTEC radiometric assay
Septichek AFB system
MGIT – mycobacterial growth indicator tube
system
14. Mantoux test
For establishing diagnosis of TB in children
Delayed type hypersensitivity reaction
0.1 ml of 5 TU PPD is injected intradermally into
the volar aspect of the forearm (or 2 TU of PPD
RT 23)
A wheal of 5 mm should be raised
Reaction is read after 48 – 72 hrs
Look for induration and erythema
15. Interpretation
48-72 hours later diameter of induration is measured
transversely to the long axis of the forearm.
Induration > 10mm is suggestive of natural infection.
5-10 mm - borderline; considered positive in
immunocompromised host
<5mm - Negative mantoux test does not rule
out TB
18. Treatment for TB
Isoniazid (INAH) 5 mg/kg/day H
Rifampicin 10 mg/kg/day R
Pyrazinamide 25 mg/kg/day Z
Ethambutol 20 mg/kg/day E
Streptomycin 20mg/kg/day S
19. 2nd Line drugs
Drug resistant cases or when first line drugs cant
be used
Eg. Cycloserine, ethionamaide, PAS, kanamycin
Other drugs
Strictly for drug resistant cases
Eg. Quinolones, rifamycin, amikacin, imipenem,
ampicillin
20. Phases of Treatment
Intensive Phase
Eliminate bacterial load
Prevent emergence of drug resistant strains
Atleast 3 Bactericidal Drugs used
Continuation Phase
Continue and complete therapy
Atleast 2 Bactericidal drugs used
23. Introduction
BCG (Bacille Calmette Guerin) prepared from
Mycobacterium bovis DANISH 1331 strain which
is closely related to Mycobacterium tuberculosis,
the agent responsible for tuberculosis.
It prevents development of more severe forms
of TB, particularly TB meningitis in children .
24. Contd..
It is freeze-dried and need to be mixed with the
correct diluent from the same manufacturer
before administration
Dose:
a vial with 20doses, dose for new born is 0.05ml.
Route:
ID into the Rt. upper arm.
BCG vaccine vials must be discarded 6hrs after
mixing.
BCG can be given up to 1 year .
31. Problem statement
As per NACO sentinel surveillance report of
2007, the prevalence of HIV infection is estimated
to be 0.34 % of the population, which translates
to 2.31 million people living with HIV/AIDS in
India.
Tuberculosis (TB) continues to be a public health
challenge in India and is estimated that 1.9 million
new cases of TB occur in India annually.
Active TB disease is the commonest opportunistic
infection amongst HIV-infected individuals.
32.
33.
34.
35. TB –HIV COLLABORATION
TB-HIV collaborative activities between RNTCP
and NACP started initially in the year 2001, in the
six states with high prevalence of HIV/AIDS i.e.
Andhra Pradesh ,Karnataka, Maharashtra,
Manipur, Nagaland and Tamil Nadu.
The collaborative activities were extended to 8
additional states in 2004.
36. OBJECTIVES
To strengthen the mechanisms for coordination
between RNTCP and NACP at National, State
and District levels.
To decrease morbidity and mortality due to
tuberculosis among persons living with HIV/AIDS.
To decrease the impact of HIV in tuberculosis
patients and provide access to HIV related care
and support to HIV- infected TB patients
37. SPECIFIC TB/HIV
COLLABORATIVE ACTIVITIES
Establish / Strengthen NACP-RNTCP
coordination mechanisms at national, state and
district level.
Scaling up of Intensified TB/HIV Package of
Services across the country.
Joint Monitoring and Evaluation including
standardized reporting shared between the two
programmes.
Training of the programme and field staff on
TB/HIV
TB and HIV service delivery coordination