The document summarizes the structure and function of hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen from the lungs to tissues and carbon dioxide from tissues back to the lungs. It is composed of heme and globin proteins. Heme contains iron and is produced in mitochondria, while globin chains are produced by ribosomes and combine with heme to form hemoglobin. The main types of hemoglobin in humans are fetal hemoglobin during development and adult hemoglobin after birth. Hemoglobin transports oxygen via an oxygen-binding reaction that allows it to efficiently deliver oxygen to tissues and receive carbon dioxide.

1. Structure and function of Haemoglobin Dr. Tariq M Roshan Department of Hematology PPSP

5. Synthesis of Haemoglobin

7. Structure of Haem

8. Synthesis of globin

10. Globin gene clusters

12. Globin chain switch

13. Alpha & beta chains

14. Adult haemoblobin 0.5-0.8 % 1.5-3.2 % 96-98 % Normal %  2  2  2  2  2  2 structure Hb F Hb A 2 Hb A

16. Oxy & deoxyhaemoglobin

18. Hb-oxygen dissociation curve