Phamacology in pregnancy& paediatrics

Pediatric and Perinatal Pharmacology www.freelivedoctor.com

[object Object],Pregnancy www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Changes during pregnancy www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Changes during pregnancy (con’t) www.freelivedoctor.com

[object Object],[object Object],[object Object],GOAL: www.freelivedoctor.com

Drug Therapy in Pregnancy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

I. Physicochemical Properties of the Drug ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

I. Physicochemical Properties of the Drug ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

[object Object],[object Object],[object Object],www.freelivedoctor.com

[object Object],www.freelivedoctor.com

[object Object],Umbilical arteries Umbilical vein Chorionic villus Placental septum Endometrial arteries and veins Intervillus space Chorion Amnion www.freelivedoctor.com

The Maternal-Fetal Unit ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

I. Physicochemical Properties of the Drug ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

II. Amount of Drug Reaching the Fetus ,[object Object],www.freelivedoctor.com

III. Exposure Rate ,[object Object],www.freelivedoctor.com

IV. Duration of Exposure ,[object Object],[object Object],www.freelivedoctor.com

V. Tissue Distribution ,[object Object],[object Object],[object Object],www.freelivedoctor.com

VI. Developmental Stage ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Fetal Development CNS Heart Eyes Legs Arms 0 5 15 Teeth Palate Ex. genitalia Ear Full term www.freelivedoctor.com

Drug Affinity for Specific Tissues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Factors Affecting Placental Transfer of Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Drug Therapy in Pregnancy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

I. Maternal Factors ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

II. Fetal Therapy ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

III. Drug Toxicity ,[object Object],[object Object],[object Object],www.freelivedoctor.com

IV. Teratogenicity ,[object Object],[object Object],[object Object],www.freelivedoctor.com

IV. Teratogenicity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Drugs that cause severe adverse effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Misoprostol Penicillamine Phencyclidine Phenytoin Propylthiouracil Streptoycin Tamoxifen Tetracycline Thalidomide Trimethadione Valproic acid Warfarin www.freelivedoctor.com

IV. Teratogenicity ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

IV. Teratogenicity ,[object Object],[object Object],www.freelivedoctor.com

IV. Teratogenicity ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Drug Therapy in Infants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Drug Therapy in Infants ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Drug Therapy in Infants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Drug Therapy in Infants ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Biotransformation of Benzodiazepines From Katzung, 1998 www.freelivedoctor.com

Drug Therapy in Infants ,[object Object],www.freelivedoctor.com

Drug Therapy in Infants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

FDA Drug Categories ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Phamacology in pregnancy& paediatrics

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