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Transfusion pathology
- 3. intro Rh ABO products other groups indications testing dangers www.freelivedoctor.com
- 10. What are the antigens? Type A Type B Type AB Type O www.freelivedoctor.com intro Rh ABO products other groups indications testing dangers
- 12. H antigen A antigen B antigen www.freelivedoctor.com intro Rh ABO products other groups indications testing dangers
- 14. www.freelivedoctor.com Genotype Antigens Blood type AA A A AO BB B B BO AB A and B AB OO None O intro Rh ABO products other groups indications testing dangers
- 15. How common is each blood type? www.freelivedoctor.com Blood type Percent of population A 40% B 12% AB 6% O 42% intro Rh ABO products other groups indications testing dangers
- 17. So what? Type A Type B Type AB Type O www.freelivedoctor.com intro Rh ABO products other groups indications testing dangers
- 18. www.freelivedoctor.com Genotype Antigens Blood type Antibodies AA A A anti-B AO BB B B anti-A BO AB A and B AB none OO None O anti-A anti-B intro Rh ABO products other groups indications testing dangers
- 19. Compatible blood types * type O = universal d O nor! www.freelivedoctor.com Recipient blood type Donor blood type A A or O * B B or O AB AB, A, B, or O O O intro Rh ABO products other groups indications testing dangers
- 23. www.freelivedoctor.com Genotype Antigens Blood type DD D Rh + Dd D Rh + dd none Rh - intro Rh ABO products other groups indications testing dangers
- 30. Whole Blood Red Cells Granulocytes Platelet-Rich Plasma BLOOD PRODUCTS www.freelivedoctor.com
- 31. Whole Blood Red Cells Granulocytes Platelet-Rich Plasma BLOOD PRODUCTS www.freelivedoctor.com
- 32. Whole Blood Red Cells Granulocytes Platelet-Rich Plasma BLOOD PRODUCTS www.freelivedoctor.com
- 33. Whole Blood Red Cells Granulocytes Platelet-Rich Plasma Platelets BLOOD PRODUCTS Fresh Frozen Plasma www.freelivedoctor.com
- 34. Whole Blood Red Cells Granulocytes Platelet-Rich Plasma Platelets Fresh Frozen Plasma VIII Cryoprecipitate BLOOD PRODUCTS IX Albumin IgG www.freelivedoctor.com
- 36. Whole Blood Use: massive hemorrhage RBC WBC platelets plasma Contents: INDICATIONS www.freelivedoctor.com
- 37. Whole Blood Red Cells Use: low hemoglobin RBC a few WBC a few platelets a little plasma Contents: INDICATIONS www.freelivedoctor.com
- 38. Whole Blood Red Cells Granulocytes Use: sepsis in neutropenic patients neutrophils Contents: INDICATIONS www.freelivedoctor.com
- 39. Whole Blood Red Cells Granulocytes Platelet-rich plasma INDICATIONS www.freelivedoctor.com
- 40. Whole Blood Red Cells Granulocytes Platelet-Rich Plasma Platelets Use: bleeding due to thrombocytopenia platelets Contents: INDICATIONS www.freelivedoctor.com
- 41. Whole Blood Red Cells Granulocytes Platelet-Rich Plasma Platelets Fresh Frozen Plasma Use: bleeding due to multiple factor deficiencies (e.g., DIC) Plasma (including ALL coagulation factors) Contents: INDICATIONS www.freelivedoctor.com
- 42. Whole Blood Red Cells Granulocytes Platelet-Rich Plasma Platelets Fresh Frozen Plasma Cryoprecipitate Uses: low fibrinogen, vW disease, hemophilia A fibrinogen von Willebrand factor VIII Contents: INDICATIONS www.freelivedoctor.com
- 43. Whole Blood Red Cells Granulocytes Platelet-Rich Plasma Platelets Fresh Frozen Plasma Cryoprecipitate INDICATIONS A bunch of other stuff Use: rarely used www.freelivedoctor.com
- 45. patient red cells (type A) FORWARD TYPE anti-A antibodies AHG Forward typing is done using both anti-A and anti-B antibodies! www.freelivedoctor.com
- 46. patient serum (with anti-B Ab) AHG reagent red cells (type B) REVERSE TYPE Reverse typing is done using both type A and type B reagent cells! www.freelivedoctor.com
- 47. patient serum AHG donor red cells CROSSMATCH www.freelivedoctor.com
- 48. patient serum AHG reagent RBC number 1 patient serum AHG reagent RBC number 2 ANTIBODY SCREEN no agglutination (negative test ) agglutination (positive test) www.freelivedoctor.com
- 58. What’s the risk of getting an infection? www.freelivedoctor.com Bug Risk Hepatitis C One in 50,000 Hepatitis B One in 100,000 HTLV One in 100,000 Bacterial infection One in a million Other infections One in a million HIV One in 2 million intro Rh ABO products other groups indications testing dangers
- 59. What’s the risk of other complications? www.freelivedoctor.com Complication Risk Allergic reaction One in 100 (severe: one in 20,000) Febrile reaction One in 200 Circulatory overload One in 3,000 Delayed hemolysis One in 4,000 (fatal: one in 4 million) Acute hemolysis One in 20,000 (fatal: one in 600,000) intro Rh ABO products other groups indications testing dangers