6 A) �Cu�l de las siguientes afirmaciones sobre la se�alizaci�n de l.pdf

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6 A) Cul de las siguientes afirmaciones sobre la sealizacin de la quinasa PI-3 NO es cierta? Las mutaciones de prdida de funcin en PTEN provocan una sealizacin excesiva de PI-3K y se encuentran en muchos cnceres humanos. La base de la inactividad de PKB en clulas no estimuladas es la autoinhibicin conformacional. La PI-3 quinasa genera molculas de sealizacin de PI 3-fosfato despus del reclutamiento en la membrana mediante la unin de su dominio SH2 a los receptores activados. La protena quinasa B activada promueve la apoptosis al fosforilar el factor de transcripcin FOXO3a. 6 B) Qu va de sealizacin pueden activar las citoquinas? JAK/STAT y PI-3 quinasa Ras/MAP quinasa Todas las respuestas son correctas. JAK/STAT PI-3 quinasa.

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