According to data recently published in Diabetes Care, the American Diabetes Association’s official journal, the number of diabetes-related limb amputations is on the rise in the United States.

1. New Algae-Based Therapy Could Prevent Lower Extremity
Amputation
According to data recently published in Diabetes Care, the American
Diabetes Association’s official journal, the number of diabetes-
related limb amputations is on the rise in the United States. Another
recent article published in the American Journal of Managed Care
notes that 200, 000 non-traumatic limb amputations occur in the US
each year. Every 17 seconds, a person is diagnosed with diabetes,
and 230 Americans living with diabetes suffer an amputation every
day. The data also estimates that a leg is amputated every 30
seconds throughout the world, and 85% of these limp
amputations are a result of diabetic foot ulcers.
These results are alarming, even scaring, especially since they come
at a time when multidisciplinary approaches in the management
and treatment of diabetic foot ulcers have been reported to
decrease amputation rates by over 50%. It, therefore, follows that
any preventative medical strategies in this field of medicine are very
welcome. The good news is that we are headed in the right direction.
New research published in the NPJ Regenerative Medicine journal suggests that algae could help prevent
lower extremity amputations. The researchers from King’s College London and St. Thomas’ Hospital have
developed a new algae-based critical limb ischemia treatment. Surgeon Prof. Bijan Modarai and his
colleagues came up with small capsules made from brown algae, key in the new therapy. The capsules were
shown to hold macrophages and increase blood flow in damaged limb tissues, accelerating the healing
process.
In the study, the researchers delivered the algae capsules to injured muscle tissues in the back limbs of
mice. The brown algae macrophages were seen to remain in the injured areas successfully, new blood
vessels were formed, and consequently, there was more blood flow to the damaged areas. The scientists
now hope to extend the research to human clinical trials. With an estimated 2 million people living with
critical limb ischemia in the US alone, these findings wouldn’t have come at a better time.
Critical limb ischemia (CLI) is a very serious condition that occurs when limb arteries become blocked due to
a build-up of fat deposits. This reduces blood flow into the limbs significantly. Research
(https://www.vasculardiseasemanagement.com/content/prevalence-incidence-and-outcomes-
critical-limb-ischemia-us-medicare-population) shows that up to 40.42% of all patients diagnosed with
CLI end up with a limb amputation. Studies have also shown that if blood flow isn’t restored in good time,
up to 50% of CLI patients will have a limb amputated or die of the condition. These statistics, again, stress
the need for effective amputation prevention measures.
In their report, the Prof. Modarai-led research team says, “we hope this new cell therapy will reduce the
need for amputations greatly in patients whose CLI has become untreatable.” As a practicing podiatric who
is frequently looking to help patients prevent limb amputation, I must admit that this new algae-based
therapy will play a critical role in therapy should it be viable on humans. It will especially be very impactful
Published: 2019-12-17 Views: 29
Author: relefordinstitute
Published in: Diabetes

2. in the prevention of diabetic amputations among high-risk and vulnerable populations across the globe.
At the Releford Foot and Ankle Institute, our goal is to decrease the diabetes-related amputation rate
both domestically and abroad. We are keeping a watchful eye on this and other innovations to help prevent
amputations in vulnerable communities and populations. Following these research findings, the future
looks bright.
Author Bio
Dr. Bill Releford, a podiatric surgeon based in Los Angeles, is a graduate of the Temple School of
Podiatric Medicine in Philadelphia. He began his practice in 1990 and established the Releford Foot
and Ankle Institute. Dr. Bill Releford specializes in diabetic amputation prevention in an effort to
reduce the astronomical diabetes-related amputation rate experienced by high-risk populations both
domestically and internationally. This disparity inspired Dr. Releford to dedicate his life to developing
innovative medical as well as outreach strategies to promote the adoption of healthier lifestyles that will
ultimately decrease the amputation rate in underserved communities.
From an outreach perspective, Dr. Bill J. Releford is the founder of the Black Barbershop Health
Outreach Program, the only national barbershop-based health initiative in the country. The program
has screened over 30,000 African American men for diabetes as well as high blood pressure throughout
the country. The ultimate goal of the program is to screen over 1 million men.
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