1. MicroRNA Research Tools, Diagnostics and Therapeutics:
Global Markets
Report Details:
Published:November 2012
No. of Pages: 138
Price: Single User License – US$4850
This report on global markets for MicroRNA Research Tools, Diagnostics and Therapeutics
provides:
•An overview of the global market for microRNA diagnostics and therapeutics, with an analysis of
the commercial potential of this research field
•Analyses of global market trends, with data from 2011, estimates for 2012, and projections of
compound annual growth rates (CAGRs) through 2017
•Examination of the extensive portfolio of miRNA pathway drug candidates, some already in
Phase II clinical trials, showing promising clinical data in different areas of medicine, such as
cancer, HCV infection, and cardiovascular diseases
•A focus on recent drug candidates, products, deals between different pharmaceutical companies,
major participants, and new trends and developments during the last two years
•Forecasts of the future situation and major drawbacks of the miRNA drug development model
and possible solutions for these obstacles, especially in context of drug stability and delivery
•Identification of the main markets for RNA therapeutics
•Comprehensive company profiles of major players in the industry.
This report provides an overview of the current state of the microRNA market, focusing specifically
on tools, reagents, techniques, diagnostics and therapeutics products. It describes products and
tests currently on the market and a detailed analysis of the competitive environments, including
new potential trends and markets for novel products and assay development. This study includes
information about significant players, trends, and obstacles and other information affecting this
market and its different sectors.
REASONS FOR DOING THIS STUDY
The microRNA phenomenon was discovered in the early 1990s. Yet only now scientists and
industry insiders are recognizing the importance of this discovery.
The microRNA biogenesis process is essentially the basis for current RNA interference drug
discovery and therapeutics research. It led to the development of a very important experimental
approach of gene silencing by synthetic double stranded RNA molecules. Today, siRNA tools are

2. among the routine laboratory techniques and essential requirements for scientific proof of
concept. Moreover, scientists came to realize that the microRNA silencing pathway is efficient in
downregulation of number of target genes, which makes it better in terms of therapeutics
development. More importantly, the microRNA expression profile represents critical signatures for
biomarker and diagnostic product development.
These facts force diagnostics and therapeutics companies to reconsider microRNA space and to
look more closely into microRNA research, diagnostics and therapeutics product development.
Although microRNAs are part of the RNA research market in general, the microRNA sector
exhibits specific characteristics and differences in its market participants and competitive
landscape.
This report highlights the main segments in the microRNA market: reagents and tools essential for
research, current diagnostics products and their development, and drug candidates in the
pipelines of different companies. This report also discusses major players, current and future
trends, and influences. Drivers and challenges in each segment of this industry are described in
detail, including forecasts for the next five years.
SCOPE AND FORMAT
This report is a business tool that can help market players properly evaluate new commercial
opportunities in the microRNA reagent, diagnostic and therapeutic submarkets. The geographic
scope of this study is global. This market is generally complex and consists of a number of
different segments, each of which is affected differently by scientific and technological
developments. This report identifies the main factors affecting each segment, and forecasts
market growth, future trends, and product development in every major segment of this market.
METHODOLOGY AND INFORMATION SOURCES
Both primary and secondary research methodologies were used in preparing this study. Initially, a
comprehensive and exhaustive search of the literature on drug discovery and already marketed
products was conducted. These secondary sources included drug discovery and science–related
journals, textbooks, press releases, marketing literature, other product/promotional literature,
annual reports, security analyst reports, and other publications. A patent search and analysis
were also conducted.
In a second phase, a series of semi–structured interviews was conducted with company
representatives, bench scientists, marketing representatives, and other personnel at biotechnology
and pharmaceutical companies. Other sources included academics, technology, and consulting
companies. Subsequent analysis of the documents and interview notes was iterative.
INTENDED AUDIENCE
This report is intended for business development professionals, entrepreneurs, and other investors
who need to fully understand and properly evaluate each segment in the market for microRNA
research tools, diagnostics and therapeutics. It provides insights into the market position of major
companies, and shows new opportunities otherwise overlooked or less known to the business

3. community.
ANALYST CREDENTIALS
Dr. Marianna Tcherpakov has more than seven years of experience as a bench scientist
specializing in biochemistry, cell biology, and industrial assay development. She has contributed
to a number of scientific publications and holds several patents. She has expertise as an assay
development scientist and is familiar with different research field trends and likely future
developments.
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Major points covered in Table of Contents of this report include
Chapter- 1: Introduction
Study Goals And Objectives
Reasons For Doing This Study
Scope And Format
Methodology And Information Sources
Intended Audience
Analyst Credentials
Related Reports
Bcc On-Line Services
Disclaimer
Chapter- 2: Summary
Table Summary : Global Market For Microrna Research Tools, Diagnostic And Therapeutic
Products, Through 2017
Figure Summary : Global Market For Microrna Research Tools, Diagnostic And Therapeutic
Products, 2010–2017
Chapter- 3: Introduction To Microrna Research
Overview
Microrna Discovery
Microrna Definition
Biogenesis Of Microrna
Function Of Microrna
Microrna Market Overview
Importance Of Patents In Microrna Research

4. Chapter- 4: Research Tools And Reagents For Microrna Research And Product
Development
Overview
Analysis Of Main Sectors In The Microrna Research Tools And Technologies Market
Summary Of Life Science Tools And Reagents Market For Microrna Research
Chapter- 5: Microrna Diagnostics And Biomarker Market
Overview
Microrna And Cancer Diagnostics
Importance Of Microrna Signatures In Different Diseases
Current State Of Microrna Diagnostic And Biomarker Product Development Market
Chapter- 6: Microrna Therapeutics In Rna Drug Discovery Market
Overview
Rna Therapeutics
Microrna Approach In Drug Discovery
Summary Of General Rna Therapeutics Drug Discovery Market
Chapter- 7: Importance Of Bioinformatics Tools And Recourses For Microrna Research And
Product Development
Overview
Effect Of Ngs Trend On Microrna Research And Bioinformatics Tool Development
Chapter- 8: New Technologies, Applications And Markets In Microrna Research And
Product Development
New Technologies And Drug Discovery Approaches
New Applications And Target Markets In Microrna Research
Chapter- 9: Market Summary For Microrna Research And Product Development
Chapter- 10: Profiles Of Select Companies
Alnylam Pharmaceuticals
Asuragen, Inc.
Exiqon A/S
Isis Pharmaceuticals

5. Mirna Therapeutics
Regulus Therapeutics
Rosetta Genomics
Santaris Pharma A/S
Chapter- 11: List Of Companies Mentioned In Report
Access Pharmaceuticals
Aegera Therapeutics
Affymetrix
Agilent Technologies
Alnylam Pharmaceuticals
Antisense Pharma Gmbh
Aparna Biosciences Corp.
Applied Biological Materials Inc.
Astrazeneca Pharmaceuticals Lp
Asuragen Inc.
Avi Biopharma/Sarepta Therapeutics
Benitec Biopharma
Biocancell Therapeutics Inc.
Biogen Idec
Calando Pharmaceuticals Inc.
Cbc Comprehensive Biomarker Center Gmbh
Cenix Bioscience Gmbh
Clontech Laboratories
Covance Inc.
Dicerna Pharmaceuticals Inc.
Egen Inc.
Eli Lilly And Co.
Emd4biosciences
Enzo Biochem
Enzon Pharmaceuticals Inc.
Exiqon A/S
F. Hoffman-La Roche Ag
Fluidigm
Genecopoeia Inc.
Genosensor Corp.
Gensignia Inc.
Genta Inc.
Groove Biopharma
Gsk U.S.
Htg Molecular Diagnostics Inc.

6. Ico Therapeutics Inc.
Idera Pharmaceuticals
Illumina Inc.
Inovio
Interna Technologies B.V.
Isis Pharmaceuticals
Lc Sciences
Life Technologies Corp.
Lorus Therapeutics Inc.
Marina Biotech
Merck
Miragen Therapeutics
Mirna Therapeutics
Nanostring Technologies
Norgen Biotek
Novartis International Ag
Opko Health Inc.
Pfizer
Phalanx Biotech Group
Phaserx
Prolias Technologies
Qiagen
Quark Pharmaceuticals Inc.
Regulus Therapeutics
Rosetta Genomics
Rxi Pharmaceuticals Corp.
Sanofi U.S.
Santaris Pharma A/S
Senesco Technologies Inc.
Sigma-Aldrich
Silence Therapeutics
Sirnaomics Inc.
Sirnasense
Sylentis
Tacere Therapeutics Inc.
Tekmira Pharmaceuticals Corp.
Theradiag
Thermo Fisher Scientific Inc.
Traversa Therapeutics Inc.
Wafergen Biosystems Inc.
List Of Tables

7. Summary Table : Global Market For Microrna Research Tools, Diagnostic And Therapeutic
Products, Through 2017
Table 1 : Global Market For Reagents And Tools For Dna/Rna Research, Through 2016
Table 2 : Market For Cancer Profiling Technologies, Through 2015
Table 3 : Patents And Patent Application Search In Microrna Research Using Specific Key Words,
Through 2012
Table 4 : Number Of Patents And Patent Applications In Microrna Research According To
Assignee
Table 5 : Types Of Reagents And Tools For Microrna Research And Drug Discovery And Their
Relative Market Share, 2011
Table 6 : Examples Of Microrna Sample Preparation Services And Their Price Ranges
Table 7 : Global Market Shares Of Rna Isolation Products By Company
Table 8 : Global Rt–Pcr Market Shares By Company, 2011
Table 9 : Platforms And Vendors Of Qrt–Pcr Producst For Microrna Research
Table 10 : Global Market For Qrt–Pcr Reagents For Microrna Research, Through 2017
Table 11 : Main Representative Microarray Products For Microrna Research
Table 12 : Annual Revenues Of Affymetrix, 2009–2011
Table 13 : Global Market For Microarray Reagents And Products For Microrna Research, Through
2017
Table 14 : Global Market For Ngs Sequencing, Through 2016
Table 15 : Ngs Market Share By Company, 2011
Table 16 : Platforms And Vendors Used For Microrna Sequencing
Table 17 : Value Of Global Ngs Sample Prep Market, Through 2016
Table 18 : Summary Of Microrna Profiling Techniques Advantages And Disadvantages
Table 19 : Examples Of Products For Functional Assays And Their Representative Vendors
Table 20 : Global Market For Research Tools In Microrna Research, Through–2017
Table 21 : Number Of Publications In Microrna Research Based On Different Search Criteria
Table 22 : Examples Of Differentially Expressed Microrna In Different Cancer Types
Table 23 : Examples Of Microrna Expression In Cvs Conditions
Table 24 : Examples Of Microrna Downregulated Or Upregulated In Different Neurodegenerative
Pathologies
Table 25 : Global Biomarkers Market, Through 2015
Table 26 : Challenges Associated With Microrna Measurements As Biomarker
Table 27 : Diagnostics Products By Rosetta Genomics
Table 28 : Revenues For Rosetta Genomics, 2009-2011
Table 29 : Global Microrna Diagnostics Market Through 2017
Table 30 : Example Of Exiqon Revenues, 2009-2012
Table 31 : Example Of Lipitor Sales As An Estimate For Kynamro, 2008-2010
Table 32 : Examples For Isis Pharmaceuticals Revenues, 2009-2011
Table 33 : Revenues Of Alnylam Pharmaceuticals And Tekmira Pharmaceuticals, 2009–2011
Table 34 : Examples Of Drug Candidates In Antisense And Rna Interference Based Approaches

8. Table 35 : Global Market For Antisense Drug Discovery Through 2017
Table 36 : Examples Of Deals And Collaboration In Rnai Therapeutics, 2009-2012
Table 37 : Global Market For Rnai Therapeutic Approach, Through 2017
Table 38 : Examples Of Microrna Differential Expression In Different Cellular Processes
Table 39 : Different Approaches For Development Of Microrna Based Therapeutics
Table 40 : Global Market For Rna Drug Delivery, Through 2017
Table 41 : Main Approaches And Techniques In Nonviral Rna Drug Delivery
Table 42 : Rna Drug Delivery Systems By Company
Table 43 : Summary Of Main Drug Development Platforms For Microrna Therapeutics: Limitations
And Advantages
Table 44 : Main Market Participants In Microrna Drug Discovery And Examples Of Their Drug
Candidates
Table 45 : Sales Of Incivek And Victrelis, 2011 And 2012
Table 46 : Revenues For Santaris Pharma And Regulus Therapeutics, 2008-2011
Table 47 : Recent Collaborations, Deals And Agreements In The Microrna Drug Discovery Market,
2008-2012
Table 48 : Global Market For Microrna Drug Discovery Through 2017
Table 49 : Global Market For Rna–Based Therapeutics, Through 2017
Table 50 : Geographical Distribution Of Rna-Based Drug Discovery Companies
Table 51 : Global Bioinformatics Market, Through 2016
Table 52 : Databases For Microrna Research
Table 53 : Examples Of Computational Tools For Microrna Prediction And Target Identification
Table 54 : Protein Targets For Drug Discovery Research In Microrna
Table 55 : Global Market For Biofuels, Through 2017
Table 56 : Global Market For Microrna Research Tools, Diagnostic And Therapeutic Products,
Through 2017
Table 57 : Main Market Participants In Microrna Research Market
List Of Figures
Summary Figure : Global Market For Microrna Research Tools, Diagnostic And Therapeutic
Products, 2010–2017
Figure Sample Figure : Global Market For Microrna Research Tools, Diagnostic And Therapeutic
Products, 2010–2017
Figure 1 : Schematic Representation Of Microrna Biogenesis And Its Effect On Protein Translation
Figure 2 : Global Market For Research Tools In Microrna Research, 2010–2017
Figure 3 : Global Microrna Diagnostics Market, 2010–2017
Figure 4 : Global Market For Microrna Drug Discovery 2010-2017
Figure 5 : Global Market For Rna Based Therapeutics, 2010-2017
Figure 6 : Global Market For Microrna Research Tools, Diagnostic And Therapeutic Products,
2010-2017

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