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Cavendish Global Health Impact Forum
October 25-28, 2015
• Ed Addison,
• Chairman, Co-Founder and CEO

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PRESENTATION TITLE
Cavendish Global Health Impact Forum
October 25-28, 2015
• Ed Addison,
• Chairman, Co-Founder and CEO

5. About Our Company
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6. About Our Company
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Our Content
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Our Company
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www.cloudpharmaceuticals.com 01

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One Column Text
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www.cloudpharmaceuticals.com 01

14. Contains every small molecule to
increase the wellness of people around
the world, to prevent people from dying,
to relieve their pain and suffering
The trick is to find the right ones
Virtual Molecular Space
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www.cloudpharmaceuticals.com 01

15. Cloud Pharmaceuticals
Atomwise
Pharmacopia
Numerate
E-Therapeutics
Verseon
Schrodinger
ACCURACY
D I V E R S I T Y
Competitive Landscape
Competitive Advantages
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Use of artificial intelligence searches novel molecular
space to identify the strongest matches to protein
targets, resulting in original IP and enormous diversity
Binding affinity of molecules to targets achieves
>80% correlation using quantum chemistry, making
our process very accurate
Biophysical models of chemical properties enables
selection of very good drug candidates
1
1
www.cloudpharmaceuticals.com 01

16. Collaboration developing
12 drugs, validation data
Grant for development
of discovery methods
and select drugs
Muscle growth
and inflammation research
Autism and cancer research Malaria collaboration
Collaboration
developing
7 drug programs
Valuable Relationships
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www.cloudpharmaceuticals.com 01

17. Pancreatic Cancer
People diagnosed50,000 Of all cancers in the US
3%
Of all cancer deaths in the US7%Will die from
pancreatic cancer40,560
Key statistics for 2015 from the American Cancer Society:

18. Quantum Molecular Design Process
How We Do It
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Design compounds that inhibit the activity of protein
targets, which are produced by the genes responsible for
certain pathologies
Combine high-performance cloud computing, quantum
mechanics/molecular mechanics, and molecular
property simulation
Fundamentally transform and improve the design of
new medicines
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03
www.cloudpharmaceuticals.com 01

19. Questions?
Ed Addison, CEO
Cloud Pharmaceuticals Inc.
6 Davis Drive
Research Triangle Park, NC 27709
(910) 398-1200
ed.addison@cloudpharmaceuticals.com

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DRUG DISCOVERY
10,000
COMPOUNDS
PRE-CLINICAL
250
CLINICAL
TRIALS
1
DRUG
Traditional
discovery has
Low probability
of success
High-throughput
screening is
Very inefficient
Timelines and costs
of past development
efforts are
Prohibitive
Previous
in silico
methods are
Unreliable
The Opportunity
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ACHIEVES
FDA APPROVAL
www.cloudpharmaceuticals.com 01

21. • Why?
• Moore's Law
• Accessibility of cloud-based
super computing
• Artificial intelligence
• How?
• Store 3D model of every
human protein in the
druggable genome
• Analyze a proposed drug for
toxicity prior to clinical trial
Emerging life sciences data center
The Time is Now for In Silico
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www.cloudpharmaceuticals.com 01

22. Appendix
1
Cloud Pharmaceuticals
Investor Overview
Fall 20152

23. AI technology identifies novel
targets by souring published
research enabling basket trials
Designs drug leads for those targets
and filters for drug properties such
as blood–brain barrier
Finding a Cure
www.cloudpharmaceuticals.com 01

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Targets pancreatic cancer
using real genomics data
Uses genome data and
DNA analysis
to discover novel drug targets
Designing drug leads for
those targets
Finding a Cure
Put your great subtitle here
www.cloudpharmaceuticals.com 01