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Serious Adverse Events Associated with use of the Anti-TNF alpha Drugs William B. Tauber, M.D. Division of Therapeutic Biologic Internal Medicine Products Center for Drug Evaluation and Research Food and Drug Administration
Introduction ,[object Object],[object Object]
Approved TNF alpha Blocking Agents ,[object Object],[object Object],[object Object]
Mechanism of Action Infliximab ,[object Object],[object Object],[object Object],[object Object],[object Object]
Mechanism of Action Etanercept ,[object Object],[object Object],[object Object]
Mechanism of Action Adalimumab ,[object Object],[object Object],[object Object],[object Object]
Serious Adverse Events- Associated with TNF blockers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Protean Role of TNF-alpha in Infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Serious Infections associated with anti-TNF-alpha Agents ,[object Object],[object Object]
Tuberculosis and Infliximab-I ,[object Object],[object Object]
Tuberculosis and Infliximab-II ,[object Object],[object Object],[object Object]
Tuberculosis and Etanercept ,[object Object],[object Object],[object Object],[object Object],[object Object]
Tuberculosis and Adalimumab ,[object Object],[object Object]
Fungal Infections and anti-TNF alpha Agents ,[object Object],[object Object],[object Object],[object Object],[object Object]
Role of TNF-alpha in Heart Failure ,[object Object],[object Object],[object Object]
Results of anti-TNF alpha Heart Failure Trials ,[object Object],[object Object],[object Object]
Serious Neurologic Adverse Events ,[object Object],[object Object]
Lymphomas Associated with Anti-TNF alpha Agents ,[object Object],[object Object]
Lymphomas and Infliximab ,[object Object],[object Object],[object Object]
Lymphomas and Etanercept ,[object Object],[object Object],[object Object]
Lymphomas and Adalimumab ,[object Object],[object Object],[object Object]
Autoimmunity and Anti-TNF alpha Agents ,[object Object],[object Object],[object Object],[object Object]
Conclusions ,[object Object],[object Object]

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Tauber

  • 1. Serious Adverse Events Associated with use of the Anti-TNF alpha Drugs William B. Tauber, M.D. Division of Therapeutic Biologic Internal Medicine Products Center for Drug Evaluation and Research Food and Drug Administration
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