by M.A Moghimi Ophthalmology resident AJUMS

5. Cystoid changes in retina.
 The differential diagnosis includes:
 ▶ Diabetic macular edema
 ▶ Branch retinal vein occlusion
 ▶ Central retinal vein occlusion
 ▶ Retinal telangiectasias (e.g. Coat’s disease, macular telangiectasia)
 ▶ Retinitis pigmentosa
 ▶ Uveitis/retinal vasculitis
 ▶ Post surgery
 ▶ Nicotinic acid maculopathy
 ▶ Vitreomacular disorders (vitreomacular traction, epiretinal membrane)
 ▶ Chronic subretinal fluid (e.g. retinal detachment, choroidal neovasclar
membrane, central
 serous chorioretinopathy)
 ▶ Idiopathic.

8. Clear subretinal fluid.
 differential diagnosis includes:
 ▶ Central serous chorioretinopathy
 ▶ Choroidal neovascular membranes (secondary to e.g.
age-related macular degeneration,
 myopia)
 ▶ Serous retinal detachments (secondary to tumors,
inflammation, trauma)
 ▶ Rhegmatogenous retinal detachment
 ▶ Tractional retinal detachment

11. RPE atrophy and loss of photoreceptors
with mild cystic change in the retina.
 differential diagnosis includes:
 ▶ Geographic atrophy secondary to age-related macular
degeneration
 ▶ Advanced chorioretinal scarring secondary to retinal
degenerations and macular dytrophies
 (e.g. retinitis pigmentosa, Stargardt’s disease, cone
dystrophy)
 ▶ Chorioretinal atrophy secondary to inflammatory
disorders (e.g. ocular histoplasmosis,
 multifocal choroiditis)
 ▶ Severe myopic degeneration
 ▶ Angioid streaks

14. OCT showing larger (between arrows) and smaller (between arrowheads) areas of
GA. In areas of GA, there is loss of the outer retinal layers and RPE. Due to absence
of the RPE in these areas, the OCT signal is able to penetrate more deeply, which
exaggerates the typical signal pattern so that there is a ‘reverse’ shadowing effect.

15. Dry age-related macular degeneration (AMD)
`Color fundus photograph of dry AMD with many drusen of varying size
intermixed with RPE hyperpigmentation and hypopigmentation. There is an area
of geographic atrophy (arrowheads), which is
difficult to appreciate clinically
OCT showing features of dry AMD. There are
many discrete, round, hill-shaped elevations
below the RPE, which are basal linear drusen
(arrows). Drusen exhibit a medium-intensity

16. Color photograph of a myopic
CNV shows a well-circumscribed,
darkly pigmented submacular lesion
involving the inferior fovea.
CNV
shows thin subretinal fluid
with overlying intraretinal
fluid at the edge of the lesion.

18. Vitreomacular adhesion.
Note the dense posterior
hyaloid face (arrows).
The retina appears to be
normal.
Vitreomacular Adhesion
and Vitreomacular
Traction
Early vitreomacular
traction/stage 1 macular
hole. The OCT shows an
adherent vitreoretinal
interface with retinal
changes.

21. an acute macular hole showing intraretinal cysts, a cuff of
subretinal fluid and an operculum . Note that the vitreous is detached from the fovea.

25. Fundus photo showing
a discrete, well-
circumscribed
elevation at the
macula
F/A in the early phase
shows an area of
hyperfluorescence
(arrowhead) with
leakage.
OCT:Neurosensory
retinal detachment. A
small pigment
epithelial detachment
CSCR

27. NPDR

28. DME

29. shows thickening with outer retinal cystic changes (arrows)
Also note the hyperreflective clusters in the outer retina, the trace subretinal fluid or SRF
(arrow) and that the external limiting membrane is relatively well-preserved in this patient
(arrow) while the IS–OS/ellipsoid layer shows some disruption centrally (arrow).

30. (A,B) BRVO with a range of findings. Note hemorrhages along the blocked
blood vessels, and the cotton wool spots (A) as well as the hard exudates (B). (C) A late
frame fluorescein angiogram with collaterals (arrows) and leakage from the vessels.

33. OCT scans through the macula of the patient (A) with diffuse
retinal thickening and cystic changes (arrows). Note the cotton
wool spots (CWS) (arrows) in the nerve fiber layer that cause
shadowing of the layers beneath them. Some hard exudates
(HE) are noted (arrow) as hyper-reflective clusters deeper
within the retina and spanning several layers. SRF is also seen
(arrow).
(B) Note that only part of the retina is thickened unlike in
CRVO.

34. Fundus photograph of a CRVO
shows four quadrants of intraretinal
hemorrhages, cotton wool spots and
retinal edema. The fluorescein
angiogram highlights the dilated,
tortuous vessels. There is blockage
noted because of the intraretinal
hemorrhages.

35. Intraretinal thickening is noted. Cystic changes are seen in the outer retina
that span multiple retinal layers. There is some subretinal fluid. The thickening
does not respect the horizontal raphe as seen on the thickness map (inset).
There is ellipsoid IS-OS disruption seen.

36. Color fundus photograph
shows sectoral retinal whitening
(arrowheads) in the distribution of
the occluded branch retinal artery.
There is also a visible embolus
(arrow).
Fluorescein angiography
(corresponding to Figure 15.1.1) shows a
significant perfusion delay in the sector of
retina affected by the branch arterial
occlusion.
BRAO

37. BRAO

38. Acute branch retinal artery occlusion. OCT vertical cut shows
inner retinal hyper-reflectivity and thickening only in the sectoral area
of retina that is affected by the branch arterial occlusion (left of
arrowheads).
As with the case in central retinal artery occlusion, the inner hyper-
reflectivity in the affected region causes shadowing of the outer layers,
which attenuates the signal from the outer retina and retinal pigment
epithelium (RPE).

39. CiRAO

41. RP

45. stargardt

48. Cone dystrophy

50. Color fundus photograph
shows
disc edema and hemorrhages
and active
lesions just nasal to the disc.
The lesions are
hypofluorescent in the
intermediate stages of a
fluorescein angiogram.
Multi focal
choroiditis

51. OCT through an active choroidal lesion demonstrates ‘solid RPE
detachments’ or drusen-like deposits below the RPE with some overlying
RPE and outer retinal atrophy
(arrow). Lesions with transretinal hyperreflectivity are also seen (arrow)

52. The OCT scan temporal to the
optic nerve shows retinal edema (arrow). Note
that the choroid appears thickened and the
posterior choroido–scleral border is not visible
(arrowhead).

53. Color fundus photograph of a patient with Vogt–Koyanagi–Harada
shows the
classic exudative posterior pole detachment (arrows). Intermediate
stage fluorescein angiography
shows multiple hyperfluorescent spots at the choroidal level and
some diffuse pooling of dye in
the subretinal space. Late stage fluorescein angiography shows disc
hyperemia and staining with
pooling of dye in the serous retinal detachment.

56. Color photograph of primary
toxoplasmosis chorioretinitis superior to the
optic nerve in a 14-year-old female who had
congenital toxoplasmosis infection.

59. Commotio retinae

61. choroidal rupture

62. Color photograph of two
separate choroidal rupture sites (arrowheads)
and shallow overlying subretinal hemorrhage
two weeks following blunt trauma
Fluorescein angiography shows
hyperfluorescence due to window defects
in the location of the two choroidal
rupture sites

63. OCT through two separate
choroidal rupture sites two weeks following
injury. Overlying subretinal hemorrhage is also
present