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Psychiatry and Palliative care
medicine
Post graduate Students
MD Phase A
Department of Psychiatry
BSMMU, Dhaka.
30.11.2013
2

Contents
•
•
•
•
•
•

Mind ,Body & Psychiatry
What's happening inside
Palliative care in psychiatry
Psychiatry in palliative care
Updates
Summary
3

Mind, body & Psychiatry
Dr Md Saleh Uddin
4

Mind & Body

• Mind body dualism
(Cartesian dualism)
Dualistic categories
Psychological
Symptoms

Physical
Symptoms

Bodily Pathology

Comorbidity

Medical disease

Psychopathology

Psychiatric
disorder

Somatization
5

• Integrated approach
Neural basis
Mind & Brain
(Two sides of same coin)
6

Mind & Body

Mental Process/Psychology/Neuro cognition
•
•
•
•
•
•
•

Perception
Emotion
Motivation
Learning
Memory
Thought
Personality etc
7

Mind & Body

Psychiatry
• Perception: Hallucination, Illusion
• Thought: Delusion, Obsession
• Mood: Mania, Depression
• Abnormal behavior etc
8

Mind & Body

Differences
• Psychology (Process)

Nice flower!

• Psychiatry (Function)

I saw that!

• Neurology (Morphology)

Seizure/ICSOL
9

Normal
functioning

MENTAL
HEALTH

Psychopathology

MENTAL
DISORDER

Mental process
10

THANK YOU
11

Inside of mind
Dr Hosnea Ara
12

Contents
•
•
•
•
•
•
•
•

Learning
Motivation
Memory
Perception
Thought
Personality
Emotion
Stress
Personality
Personality can be defined as the unique patterning of
behavioral and mental process that characterizes an
individual and the individuals interactions with the
environment
Perspective on personality
1.
2.
3.
4.

Psychodynamic perspective
Trait perspective
Behavioral perspective
Humanistic perspective
personality

• Types of Personality
Introvert
Extrovert
• Personality Trait
• Personality Factors
Emotion
An emotion defined by psychologist usually
includes three components...
1.A characteristics feeling or subjective experience
2.A pattern of physiological arousal

3.A pattern of overt expression
emotion

Types:
• Positive emotions

• Negative emotions
• Primary emotions

• Complex emotions
• Opposite emotion
Stress
Stress can be defined as a disruption of our normal
psychological and physiological functioning that occurs
when a challenge threatens our ability to cope
adequately
Stressful events
Minor or daily hassles
Chronic sources of stress
Stress

Stress reaction
1. Disruption of emotion
2. Cognitive disruption
3. Physiological disruption
Methods of coping

1.Emotion focused
2.Problem focused
19

THANK YOU
20

Palliative care in Psychiatry
Dr. Towhidul Islam
• A 42 year old lady suffering from MDD for last
10 years consulted with her psychiatrist
complaining recent low mood , anorexia, weight
loss and headache , insomnia and suicidal
ideation.
• Her husband informed that she had cough for
last one month
Who needs palliative care in
psychiatric population?
•
•
•
•
•
•
•
•

Schizophrenia
Major Depressive Disorder
Bipolar mood disorder
Dementia
PTSD
PD
Anorexia Nervosa
Organic /Secondary
Why ?
• Psychiatric disease itself may be non-curable, potentially
life threatening due to higher suicidal and accident rates
• Patient with severe persistent psychiatric illness (SMPI)
has double the incidence than general population of
diseases including neoplasm.
• Patients are often neglected , marginalized both by
family and medical community
• Patient often fail to communicate symptoms further
complicating diagnosis and management
How?
• Palliative care should be provided to psychiatric
patients in the same way it is provided to any
other -needs for pain and symptom control,
maintenance of function, enhancement of
quality of life, support for relationships, and the
possibility of dying well

• Unique nature of psychiatric patient should be
taken in to account
How?

• A therapeutic relationship based on respect, dignity,
hope, and nonabandonment is central to this
approach
• Access to care should be ensured

• Revise or develop policies and guidelines to address
the needs of this population.
• Integrate principles of hospice palliative care in endof-life care for people with SPMI
• Conduct more research specific to this population
Challenges
• Different presentation of diseases than general
population
• Psychiatric units may not be trained to deal with
palliative needs.
• Palliative units may not be trained to deal with
psychiatric problems.
• Patient‟s difficulty to exercise autonomy in decision
making
Can we overcome the challenges?
Similarities
Something is common

A person-centered practice
Relationship- based connectedness
Compassionate and Holistic Care
Respect for autonomy and choice
Concern for quality of life as defined by the
client
• Focus on family as unit of care
• Concern to keep patient in familiar environment
•
•
•
•
•
Next steps
• Cross training ( already started !!!)
• Multi disciplinary assessment
• Multi disciplinary treatment planning
• Service integration
THANK YOU
32

Psychiatry in palliative care
Dr Mahjabeen Aftab Solaiman
What is Palliative Care?
• Medical care that focuses on alleviating the
intensity of symptoms of disease.
• Palliative care focuses on reducing the
prominence and severity of symptoms.
WHO Definition
“An approach that improves the quality of life of
patients and their families facing the problems
associated with life-threatening illness, through
the prevention and relief of suffering by means
of
early
identification
and
impeccable
assessment and treatment of pain and other
problems, physical, psychosocial and spiritual."
Aspects of Palliative Care
 Provides relief from pain and other distressing symptoms
 Affirms life and regards dying as a normal process
 Intends neither to hasten or postpone death

 Integrates the psychological and spiritual aspects of patient care
 Offers a support system to help patients live as actively as possible
until death
 Offers support system to help the family cope during the patients
illness and in their own bereavement
 Uses a team approach to address the needs of patients and their
families, including bereavement counseling, if indicated
Aspects of Palliative Care

 Enhances quality of life, and may also positively influence the
course of illness
 Applicable early in the course of illness, in conjunction with
other therapies that are intended to prolong life, such as
chemotherapy or radiation therapy, and includes those
investigations needed to better understand and manage
distressing clinical complications
 Overall improvement of the quality of life for individuals who
are suffering from severe diseases
 Offers a diverse array of assistance and care to the terminal
patients.
Psychiatry in Palliative Care
• Common Symptoms in Palliative Patients





Pain
Fatigue
Somnolence
Gastro-intestinal problem
Psychiatry in Palliative Care

• Spectrum of Disorder 50%
0%

80%

Normal Response to
Terminal Diseases
Day-to-Day Stress

Adjustment
Disorders
With depressive &
Anxiety symptoms

Crisis
Depression
Delirium
Anxiety Disorder
Personality Disorder
Others

100%
Psychiatry in Palliative Care

• Periods of Distress
Psychiatry in Palliative Care

• Major Psychiatry issues in Palliative Care
▫ Depression
▫ Anxiety
▫ Delirium
Depression
Depression
• Median prevalence of major depression in
advanced cancer 15% (5-26%)
• Often undiagnosed or under diagnosed
▫ Low mood „understandable‟
▫ Some physical symptoms – appetite change,
lethargy, sleep disturbance – common in
advanced cancer
Depression
• The Depression Continuum
Normal (Grief / Stress Reaction)

Adjustment Disorder
Minor Depression (Sub Clinical)
Major Depression (Functional /
Organic)
Depression
• Diagnosis of Depression
▫
▫
▫
▫
▫
▫
▫

Weight change
Sleep disturbance
Psychomotor problems
Lack of energy
Excessive guilt
Poor concentration
Suicidal ideation
Causes
• Illness Related Causes
▫ Persistent symptoms eg pain
▫ Increased physical impairment or discomfort
▫ Treatment-related eg radiotherapy,
chemotherapy, drugs such as corticosteroid,
▫ Endocrine/Metabolic abnormalities e.g .
hypothyroidism, hypercalcemia,
▫ Types: Pancreatic, head & neck cancer
Causes

• Others
▫ History of depression, suicide attempts
▫ Family history of depression (genetic
vulnerability)
▫ History of alcoholism or drug abuse
▫ Concurrent Life stressors e.g. going
through divorce, financial strain
Management
• Medication
• Psychosocial Intervention
• Psychological Therapy
Anxiety
Causes
•
•
•
•

Disease & Treatment Related Anxiety
Substance Induced Anxiety
Reactive Anxiety / Adjustment
Psychiatric Anxiety
Symptoms
• Physical
Autonomic Hyperactivity, Insomnia, Loss of Appetite

• Mood
Anxiety, Irritable, Vigilance

• Cognitive
Impaired Concentration, Negative Thinking, Excessive
Worrying
Management
• Relieving Pain & other Distressing Symptoms
• Medication / Drugs Adjustment
• Psychological methods
▫ Explanation
▫ CBT, relaxation therapy
▫ Counseling
Delirium
Delirium
• Is an acute state of confusion
• Characterized by mental clouding – poor
attention, disorientation, cognitive impairment
• Fluctuating conscious level
• Common in hospitalized elderly patients
Symptoms
• Early Symptoms
▫ Transient periods of disorientation esp time
(confused)
▫ Irritability , restless
▫ Withdrawal , refusal to talk
▫ Forgetfulness that was not previously present
Symptoms

• Advanced Symptoms
▫ Disorientated to time, place and person
▫ Delusion – often paranoid
▫ Hallucinations - visual , auditory
Causes
•
•
•
•
•
•

Intracranial pathology
Metabolic e.g. Organ failure, electrolyte disturbance
Sepsis
Drugs
Drug withdrawal
Circulatory e.g. dehydration

But often patients are too frail for a thorough
search for causes
Management
• Treatment of the cause
▫ Including review of medications

• General measures
▫ Well-lit, calming environment
▫ Try to avoid restraints

• Drug treatment
THANK YOU
59

Palliative care psychiatry
Dr Md Saleh Uddin
60

Talk plan
• The need for psychiatry

• Recent Advances
• Steps ahead
61

Why needed?
• “Total pain”
• Psychiatric syndromes
Normal response?
Unrecognized?
Primary/ Secondary?
Chronic cases?
Interventions?
62

Recent Updates
• Psychotherapy
• Depression, Anxiety, Delirium
• Models of care, Education, System development
63

Recent updates
64

Recent updates

Psychotherapy
(Randomized Clinical Trial)

• Dignity therapy: Existential distress
Greater level ofPerceived helpfulness, Improved QOL, Greater dignity,
Helpfulness to the family
• Meaning centered group psychotherapy(MCGP):
Bolster meaning and spiritual wellbeing.
65

Recent updates

Clinical syndromes:
• Hospice patient: 50% -depression, 70%-anxiety
Nearly all- Delirium
• Depression

• Anxiety
• Delirium

Stimulants (Methylphenidate)
Ketamine
Non pharmacological (Hypnotherapy,
Concreteness training)
No clinical trial
66

Recent updates

Education, Models of care
• Educational opportunity (training)
• Integration model
Liaison consultation
Part of team
67

Steps ahead
• Distinguishing variations of illness
• Managing Comorbidities
• Ethical issues
68

Summary
• Mental Health and mental illness is not
synonymous.

• EBM approach of management.
• Education is needed both way.
• Palliative care psychiatry is an emerging
dimension.
69

References
•

Shorter Oxford textbook of Psychiatry, Sixth edition, Philip Cowen, Paul Harrison, Tom Burns,
Oxford university press, 2012

•

Oxford Handbook of Psychiatry, Third edition, David Semple, Roger Smyth, Oxford university
press, 2013

•

Psychology, Fourth edition, Andrew B Crider, George R Goethals, Robert D Kavanaugh, Paul R
Solomon, Harper Collins College Publisher, 1933

•

Desk reference to the DIAGNOSTIC CRITERIA from DSM5, American Psychiatric Association,
2013

•

Palliative care Psychiatry: Update n Emerging Dimension of Psychiatric Practice, N Fairman, S A
Irwin, Corr Psychiatry Rep (2013)15:374, Springer

•

Availability of psychiatric consultation liaison services as an integral components of palliative care
programs at Japanese cancer Hospital, Aogawa et al, Jpn J Clin Oncol 2012; 42(1)42-52

•

Palliative Medicine and Psychiatry, Editorial, AD Macleod, Journal of Palliative Medicine, Volume
16, Number 4, 2013

•

How we can improve end of life care, Rachel Kester, Psychiatry resident, Residents voice, Current
Psychiatry, Vol 12, No5, 2013
70

References
• Plaskota M, Lucas C, Pizzoferro K, et al. A hypnotherapy intervention for the
treatment of anxiety in patient with cancer receiving palliative care, Int J Palliat
Nurse. 2012;18(2):69-75
• Chochinov HM, Hack T, et al. Dignity therapy: a novel psychotherapeutic
intervention for pateints near the end of life, J clin Oncol, 2005;23(24)5520-5525.
• Breibart W et al. Meaning centered psychotherapy for patient with advance cancer:
pilot randomized controlled trial, psychooncology, 2010 january‟19(1) 21-28
71
72

THANK YOU

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Psychiatry and palliative care medicine

  • 1. 1 Psychiatry and Palliative care medicine Post graduate Students MD Phase A Department of Psychiatry BSMMU, Dhaka. 30.11.2013
  • 2. 2 Contents • • • • • • Mind ,Body & Psychiatry What's happening inside Palliative care in psychiatry Psychiatry in palliative care Updates Summary
  • 3. 3 Mind, body & Psychiatry Dr Md Saleh Uddin
  • 4. 4 Mind & Body • Mind body dualism (Cartesian dualism) Dualistic categories Psychological Symptoms Physical Symptoms Bodily Pathology Comorbidity Medical disease Psychopathology Psychiatric disorder Somatization
  • 5. 5 • Integrated approach Neural basis Mind & Brain (Two sides of same coin)
  • 6. 6 Mind & Body Mental Process/Psychology/Neuro cognition • • • • • • • Perception Emotion Motivation Learning Memory Thought Personality etc
  • 7. 7 Mind & Body Psychiatry • Perception: Hallucination, Illusion • Thought: Delusion, Obsession • Mood: Mania, Depression • Abnormal behavior etc
  • 8. 8 Mind & Body Differences • Psychology (Process) Nice flower! • Psychiatry (Function) I saw that! • Neurology (Morphology) Seizure/ICSOL
  • 11. 11 Inside of mind Dr Hosnea Ara
  • 13. Personality Personality can be defined as the unique patterning of behavioral and mental process that characterizes an individual and the individuals interactions with the environment Perspective on personality 1. 2. 3. 4. Psychodynamic perspective Trait perspective Behavioral perspective Humanistic perspective
  • 14. personality • Types of Personality Introvert Extrovert • Personality Trait • Personality Factors
  • 15. Emotion An emotion defined by psychologist usually includes three components... 1.A characteristics feeling or subjective experience 2.A pattern of physiological arousal 3.A pattern of overt expression
  • 16. emotion Types: • Positive emotions • Negative emotions • Primary emotions • Complex emotions • Opposite emotion
  • 17. Stress Stress can be defined as a disruption of our normal psychological and physiological functioning that occurs when a challenge threatens our ability to cope adequately Stressful events Minor or daily hassles Chronic sources of stress
  • 18. Stress Stress reaction 1. Disruption of emotion 2. Cognitive disruption 3. Physiological disruption Methods of coping 1.Emotion focused 2.Problem focused
  • 20. 20 Palliative care in Psychiatry Dr. Towhidul Islam
  • 21. • A 42 year old lady suffering from MDD for last 10 years consulted with her psychiatrist complaining recent low mood , anorexia, weight loss and headache , insomnia and suicidal ideation. • Her husband informed that she had cough for last one month
  • 22. Who needs palliative care in psychiatric population? • • • • • • • • Schizophrenia Major Depressive Disorder Bipolar mood disorder Dementia PTSD PD Anorexia Nervosa Organic /Secondary
  • 23. Why ? • Psychiatric disease itself may be non-curable, potentially life threatening due to higher suicidal and accident rates • Patient with severe persistent psychiatric illness (SMPI) has double the incidence than general population of diseases including neoplasm. • Patients are often neglected , marginalized both by family and medical community • Patient often fail to communicate symptoms further complicating diagnosis and management
  • 24. How? • Palliative care should be provided to psychiatric patients in the same way it is provided to any other -needs for pain and symptom control, maintenance of function, enhancement of quality of life, support for relationships, and the possibility of dying well • Unique nature of psychiatric patient should be taken in to account
  • 25. How? • A therapeutic relationship based on respect, dignity, hope, and nonabandonment is central to this approach • Access to care should be ensured • Revise or develop policies and guidelines to address the needs of this population. • Integrate principles of hospice palliative care in endof-life care for people with SPMI • Conduct more research specific to this population
  • 26. Challenges • Different presentation of diseases than general population • Psychiatric units may not be trained to deal with palliative needs. • Palliative units may not be trained to deal with psychiatric problems. • Patient‟s difficulty to exercise autonomy in decision making
  • 27. Can we overcome the challenges?
  • 29. Something is common A person-centered practice Relationship- based connectedness Compassionate and Holistic Care Respect for autonomy and choice Concern for quality of life as defined by the client • Focus on family as unit of care • Concern to keep patient in familiar environment • • • • •
  • 30. Next steps • Cross training ( already started !!!) • Multi disciplinary assessment • Multi disciplinary treatment planning • Service integration
  • 32. 32 Psychiatry in palliative care Dr Mahjabeen Aftab Solaiman
  • 33. What is Palliative Care? • Medical care that focuses on alleviating the intensity of symptoms of disease. • Palliative care focuses on reducing the prominence and severity of symptoms.
  • 34. WHO Definition “An approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial and spiritual."
  • 35. Aspects of Palliative Care  Provides relief from pain and other distressing symptoms  Affirms life and regards dying as a normal process  Intends neither to hasten or postpone death  Integrates the psychological and spiritual aspects of patient care  Offers a support system to help patients live as actively as possible until death  Offers support system to help the family cope during the patients illness and in their own bereavement  Uses a team approach to address the needs of patients and their families, including bereavement counseling, if indicated
  • 36. Aspects of Palliative Care  Enhances quality of life, and may also positively influence the course of illness  Applicable early in the course of illness, in conjunction with other therapies that are intended to prolong life, such as chemotherapy or radiation therapy, and includes those investigations needed to better understand and manage distressing clinical complications  Overall improvement of the quality of life for individuals who are suffering from severe diseases  Offers a diverse array of assistance and care to the terminal patients.
  • 37. Psychiatry in Palliative Care • Common Symptoms in Palliative Patients     Pain Fatigue Somnolence Gastro-intestinal problem
  • 38. Psychiatry in Palliative Care • Spectrum of Disorder 50% 0% 80% Normal Response to Terminal Diseases Day-to-Day Stress Adjustment Disorders With depressive & Anxiety symptoms Crisis Depression Delirium Anxiety Disorder Personality Disorder Others 100%
  • 39. Psychiatry in Palliative Care • Periods of Distress
  • 40. Psychiatry in Palliative Care • Major Psychiatry issues in Palliative Care ▫ Depression ▫ Anxiety ▫ Delirium
  • 42. Depression • Median prevalence of major depression in advanced cancer 15% (5-26%) • Often undiagnosed or under diagnosed ▫ Low mood „understandable‟ ▫ Some physical symptoms – appetite change, lethargy, sleep disturbance – common in advanced cancer
  • 43. Depression • The Depression Continuum Normal (Grief / Stress Reaction) Adjustment Disorder Minor Depression (Sub Clinical) Major Depression (Functional / Organic)
  • 44. Depression • Diagnosis of Depression ▫ ▫ ▫ ▫ ▫ ▫ ▫ Weight change Sleep disturbance Psychomotor problems Lack of energy Excessive guilt Poor concentration Suicidal ideation
  • 45. Causes • Illness Related Causes ▫ Persistent symptoms eg pain ▫ Increased physical impairment or discomfort ▫ Treatment-related eg radiotherapy, chemotherapy, drugs such as corticosteroid, ▫ Endocrine/Metabolic abnormalities e.g . hypothyroidism, hypercalcemia, ▫ Types: Pancreatic, head & neck cancer
  • 46. Causes • Others ▫ History of depression, suicide attempts ▫ Family history of depression (genetic vulnerability) ▫ History of alcoholism or drug abuse ▫ Concurrent Life stressors e.g. going through divorce, financial strain
  • 47. Management • Medication • Psychosocial Intervention • Psychological Therapy
  • 49. Causes • • • • Disease & Treatment Related Anxiety Substance Induced Anxiety Reactive Anxiety / Adjustment Psychiatric Anxiety
  • 50. Symptoms • Physical Autonomic Hyperactivity, Insomnia, Loss of Appetite • Mood Anxiety, Irritable, Vigilance • Cognitive Impaired Concentration, Negative Thinking, Excessive Worrying
  • 51. Management • Relieving Pain & other Distressing Symptoms • Medication / Drugs Adjustment • Psychological methods ▫ Explanation ▫ CBT, relaxation therapy ▫ Counseling
  • 53. Delirium • Is an acute state of confusion • Characterized by mental clouding – poor attention, disorientation, cognitive impairment • Fluctuating conscious level • Common in hospitalized elderly patients
  • 54. Symptoms • Early Symptoms ▫ Transient periods of disorientation esp time (confused) ▫ Irritability , restless ▫ Withdrawal , refusal to talk ▫ Forgetfulness that was not previously present
  • 55. Symptoms • Advanced Symptoms ▫ Disorientated to time, place and person ▫ Delusion – often paranoid ▫ Hallucinations - visual , auditory
  • 56. Causes • • • • • • Intracranial pathology Metabolic e.g. Organ failure, electrolyte disturbance Sepsis Drugs Drug withdrawal Circulatory e.g. dehydration But often patients are too frail for a thorough search for causes
  • 57. Management • Treatment of the cause ▫ Including review of medications • General measures ▫ Well-lit, calming environment ▫ Try to avoid restraints • Drug treatment
  • 60. 60 Talk plan • The need for psychiatry • Recent Advances • Steps ahead
  • 61. 61 Why needed? • “Total pain” • Psychiatric syndromes Normal response? Unrecognized? Primary/ Secondary? Chronic cases? Interventions?
  • 62. 62 Recent Updates • Psychotherapy • Depression, Anxiety, Delirium • Models of care, Education, System development
  • 64. 64 Recent updates Psychotherapy (Randomized Clinical Trial) • Dignity therapy: Existential distress Greater level ofPerceived helpfulness, Improved QOL, Greater dignity, Helpfulness to the family • Meaning centered group psychotherapy(MCGP): Bolster meaning and spiritual wellbeing.
  • 65. 65 Recent updates Clinical syndromes: • Hospice patient: 50% -depression, 70%-anxiety Nearly all- Delirium • Depression • Anxiety • Delirium Stimulants (Methylphenidate) Ketamine Non pharmacological (Hypnotherapy, Concreteness training) No clinical trial
  • 66. 66 Recent updates Education, Models of care • Educational opportunity (training) • Integration model Liaison consultation Part of team
  • 67. 67 Steps ahead • Distinguishing variations of illness • Managing Comorbidities • Ethical issues
  • 68. 68 Summary • Mental Health and mental illness is not synonymous. • EBM approach of management. • Education is needed both way. • Palliative care psychiatry is an emerging dimension.
  • 69. 69 References • Shorter Oxford textbook of Psychiatry, Sixth edition, Philip Cowen, Paul Harrison, Tom Burns, Oxford university press, 2012 • Oxford Handbook of Psychiatry, Third edition, David Semple, Roger Smyth, Oxford university press, 2013 • Psychology, Fourth edition, Andrew B Crider, George R Goethals, Robert D Kavanaugh, Paul R Solomon, Harper Collins College Publisher, 1933 • Desk reference to the DIAGNOSTIC CRITERIA from DSM5, American Psychiatric Association, 2013 • Palliative care Psychiatry: Update n Emerging Dimension of Psychiatric Practice, N Fairman, S A Irwin, Corr Psychiatry Rep (2013)15:374, Springer • Availability of psychiatric consultation liaison services as an integral components of palliative care programs at Japanese cancer Hospital, Aogawa et al, Jpn J Clin Oncol 2012; 42(1)42-52 • Palliative Medicine and Psychiatry, Editorial, AD Macleod, Journal of Palliative Medicine, Volume 16, Number 4, 2013 • How we can improve end of life care, Rachel Kester, Psychiatry resident, Residents voice, Current Psychiatry, Vol 12, No5, 2013
  • 70. 70 References • Plaskota M, Lucas C, Pizzoferro K, et al. A hypnotherapy intervention for the treatment of anxiety in patient with cancer receiving palliative care, Int J Palliat Nurse. 2012;18(2):69-75 • Chochinov HM, Hack T, et al. Dignity therapy: a novel psychotherapeutic intervention for pateints near the end of life, J clin Oncol, 2005;23(24)5520-5525. • Breibart W et al. Meaning centered psychotherapy for patient with advance cancer: pilot randomized controlled trial, psychooncology, 2010 january‟19(1) 21-28
  • 71. 71