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Owen
Harper
Dr waleed tawfik
Ass.lecturer OB &Gyn
Benha university
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
 What is
 Does it stimulate reproductive
Human release
 Is it helpful in IVF
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
 Kisspeptins are a family of proteins that are
essential for fertility.
 The first gene member of the family was
discove...
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
 Kisspeptin is produced from
the hypothalamus and causes a chain reaction
which leads to production of neurotransmitters
...
 LH FSH
Estrogen /
testesterone
Kisspeptin/GPR54
hypothalmus
Ant. pitutary
gonads
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
HCG trigger
FSH stimulation
mature
immature
ovary
Excessive
stimulation
OHSS
16/4/2015waleed tawfik,benha university
Pleural effusion
Ascites
Renal failure
16/4/2015waleed tawfik,benha university
 Ovarian hyperstimulation syndrome (OHSS) is
a major medical problem.
 It can be fatal in severe cases and it occurs in
...
GnRh
hypothalamus
kisspeptin
GnRH agonist
Ant pitutary
ovary HCGLH
receptor
LH FSH
16/4/2015waleed tawfik,benha university
Kisspeptin is a novel
physiological trigger
for inducing oocyte
maturation in IVF
therapy
16/4/2015waleed tawfik,benha uni...
16/4/2015waleed tawfik,benha university
rFSH
GnRH
ant
rFSH
GnRH
ant
16/4/2015waleed tawfik,benha university
53 patients
1.6/3.2 nmol/kg
N=(5)
6.4nmol/kg
N=(24)
12.8 nmol/kg
N=(24)
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
16/4/2015waleed tawfik,benha university
 We are in front of a new revolution in
human reproduction understanding.
 Kisspeptin can be used as a novel
physiologic...
16/4/2015waleed tawfik,benha university
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Kisspeptin hope about to become reality

dr waleed tawfik

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Kisspeptin hope about to become reality

  1. 1. Owen Harper Dr waleed tawfik Ass.lecturer OB &Gyn Benha university 16/4/2015waleed tawfik,benha university
  2. 2. 16/4/2015waleed tawfik,benha university
  3. 3. 16/4/2015waleed tawfik,benha university
  4. 4. 16/4/2015waleed tawfik,benha university
  5. 5.  What is  Does it stimulate reproductive Human release  Is it helpful in IVF 16/4/2015waleed tawfik,benha university
  6. 6. 16/4/2015waleed tawfik,benha university
  7. 7.  Kisspeptins are a family of proteins that are essential for fertility.  The first gene member of the family was discovered in 1996 (KISS 1) by a group working in Hershey, Pennsylvania. It is named after the city’s chocolate ‘Kisses’, which are made in Hershey. 16/4/2015waleed tawfik,benha university
  8. 8. 16/4/2015waleed tawfik,benha university
  9. 9. 16/4/2015waleed tawfik,benha university
  10. 10.  Kisspeptin is produced from the hypothalamus and causes a chain reaction which leads to production of neurotransmitters from the pituitary gland. The neurotransmitter signals lead to the release of other hormones (luteinising hormone and follicle stimulating hormone) into the blood. These act on testes andovaries to produce the sex hormones testosterone and oestradiol, which cause the physical and emotional changes that are well recognised during puberty. Dhillo et al .,2005 16/4/2015waleed tawfik,benha university
  11. 11.  LH FSH Estrogen / testesterone Kisspeptin/GPR54 hypothalmus Ant. pitutary gonads 16/4/2015waleed tawfik,benha university
  12. 12. 16/4/2015waleed tawfik,benha university
  13. 13. HCG trigger FSH stimulation mature immature ovary Excessive stimulation OHSS 16/4/2015waleed tawfik,benha university
  14. 14. Pleural effusion Ascites Renal failure 16/4/2015waleed tawfik,benha university
  15. 15.  Ovarian hyperstimulation syndrome (OHSS) is a major medical problem.  It can be fatal in severe cases and it occurs in women undergoing IVF treatment who are otherwise very healthy.  We really need more effective natural triggers for egg maturation during IVF treatment 16/4/2015waleed tawfik,benha university
  16. 16. GnRh hypothalamus kisspeptin GnRH agonist Ant pitutary ovary HCGLH receptor LH FSH 16/4/2015waleed tawfik,benha university
  17. 17. Kisspeptin is a novel physiological trigger for inducing oocyte maturation in IVF therapy 16/4/2015waleed tawfik,benha university
  18. 18. 16/4/2015waleed tawfik,benha university
  19. 19. rFSH GnRH ant rFSH GnRH ant 16/4/2015waleed tawfik,benha university
  20. 20. 53 patients 1.6/3.2 nmol/kg N=(5) 6.4nmol/kg N=(24) 12.8 nmol/kg N=(24) 16/4/2015waleed tawfik,benha university
  21. 21. 16/4/2015waleed tawfik,benha university
  22. 22. 16/4/2015waleed tawfik,benha university
  23. 23. 16/4/2015waleed tawfik,benha university
  24. 24. 16/4/2015waleed tawfik,benha university
  25. 25. 16/4/2015waleed tawfik,benha university
  26. 26. 16/4/2015waleed tawfik,benha university
  27. 27.  We are in front of a new revolution in human reproduction understanding.  Kisspeptin can be used as a novel physiological trigger for egg maturation in IVF therapy.  Future studies will assess efficacy in women at high risk of OHSS. 16/4/2015waleed tawfik,benha university
  28. 28. 16/4/2015waleed tawfik,benha university

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