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Dr. Adhiraj Mishra, M.V.Sc (1st Year), Div. of Epidemiology
Dr. DK Singh, Principal Scientist, Veterinary Public Health
Dr. Bhoj R Singh, Principal Scientist and Head, Division of Epidemiology
MAGNITUDE OF GLOBAL TRAVEL
 International arrivals will
reach 1.6 billion by 2020.

International Tourist (million)

903

940

2007

2010

 Travel to developing
countries increased from

31 % to 47% and to Asia
Pacific and Middle East
have doubled in last
decade.
(UNWTO-2012)

435

1990
MODE OF TRAVEL

6%

41%

51%
(UNWTO-2012)
REASON OF TRAVEL

International Travel & Health, 2012
TRAVEL RELATED RISK factors
 Mode of transport.
 Destination.
 Duration and season of travel.

 Purpose of travel.
 Behaviour of the travellers.

 Underlying health of the travellers.
AIR TRAVEL & Associated Risks
 Quality of Aircraft cabin






air & HEPA Filter.
Auxiliary Air Unit.
Aircraft Disinsection.
Disease
transmission:
Coughing, sneezing and
direct or indirect contact.
e.g-TB, Influenza, SARS
SEA TRAVEL & Associated Risks
 13 million passengers travel worldwide on cruise ship.

(UNWTO).
 Disease transmission through: Contaminated food &
Water, Whirlpool spa, inhalation. e.g. Gastroenteritis
(2006), Influenza & other RTI, Legionellosis (1994)
(International Travel & Health, 2012)
MODES OF DISEASE TRANSMISSION
Routes

Diseases

Food borne &
Waterborne

Traveller’s diarrhoea,
Cholera,
Cryptosporidiosis,
Giardiaisis, Hepatitis A & E, Listeriosis & Typhoid Fever

Air borne

TB, SARS, Mumps, diptheria, measles

Vector Borne
Animal Borne

Malaria, Yellow Fever, Dengue, Japanese Encephalitis,
Chikungunya & Tick borne encephalitis.
Rabies, Brucellosis, Leptospirosis

Blood borne

Hepatitis B & C, HIV/AIDS and Malaria

Sexually Transmitted

Hepatitis, HIV/AIDS & Syphilis

Soil borne

Anthrax, Ascariasis, Trichuris, Fungal infections

Recreational Water

Leptospira, Pseudomanas, Legionellosis, Schistosoma,
CLM, Giardia, Cryptosporidium, Tinea & Cutaneous
papilloma.
DISEASE DIAGNOSIS BY GEOSENTINEL SITES
Diagnosis

Cases

Malaria

1,762

Giardiasis

1,296

Dengue Fever

888

Campylobacteriosis

596

Cutaneous Larva migrans

577

Rabies P E Prophylaxis

349

Enteric Fever

262

Spotted Fevers

220

Chikungunya

120

Acute Hepatitis A

94

Confirmed Influenza A/B

84
Leader K, Torresi J et al, 2013
SEVERE ACUTE RESPIRATORY SYNDROME (SARS)
 Zoonotic viral disease caused by the SARS-CoV.
 By July 2003, 8,273 cases and 775 deaths reported in

multiple countries (9.6% fatality rate). Within weeks, SARS
spread from Hong Kong to 37 countries in early 2003.
(WHO)
 1st seen- Guangdong Province of China-16th Nov, 2002
 Dr. Liu Jianlun reached Hong Kong-21st Feb, 2003
 Stayed in Metropole Hotel Room No.911 and shifted to
Hospital on 22nd Feb 2003 and died on 4th March
Contd.
 American businessman who stayed

in the same hotel, now travelling
from China to Singapore had
emergency landing in Vietnam and
died.
 Disease
spread
to
Canada, Singapore, China, Vietnam
, United States, Mongolia etc.
 WHO issued global alert on 12th
March 2003.
 1st case in India- 32 year man in
Goa, who returned from Hong
Kong and Singapore on 17th April
2003.
GLOBAL SPREAD OF SARS

The WHO Report, 2003
PANDEMIC INFLUNZA (H1N1)
 “pH1N1", 1st identified in April 2009, and

initially spread in Mexico and then
globally.
 Emerged from pigs in Asia, and was
carried to North America by infected
persons.
 The first case of the Swine flu in India -on
13 May 2009, when a 23 year old man
travelling by Emirates Airline from New
York to Hyderabad via Dubai.
AVIAN INFLUNZA (H5N1)
 Avian influenza A (H5N1), first seen in Hong Kong in

1997. Then, it reappeared in Vietnam in 2003 and has
been in continuous circulation ever since.
 H5N1 has primarily affected poultry, from 2003
through 2011, 578 human illnesses in 15 countries were
reported, with an alarming case-fatality ratio of 59%.
 The countries with the most cases of human disease
(Indonesia, Vietnam, and Egypt) account for 80% of
all cases and 78% of all deaths.
(Ostroff SM, 2012)
AVIAN INFLUENZA IN CHINA
 Avian influenza A (H7N9) virus was first reported in

China among human beings and poultry.
 Till 6th Nov, 2o13, 139 H7N9 human infections were
reported & 45 people died. (ProMED-Mail).
 Person-to-person spread of H7N9 is rare.
PREVENTION OF RESPIRATORY
INFECTIONS








Frequent washing of hands with
soap & water.
Disinfection
of
household
surfaces.
Wear disposable gloves and
apron and N-95 mask.
Eye protection (e.g. face shield or
goggles) if splash or spray of
body fluids is likely.
Thermal Screening at airport &
Quarantine.
Social distancing.
HIV/AIDS and Travel
 HIV-I pandemic started by

mid 70s and 80s spread to
five continents through air
travel, sea travel and human
migration.
 Case of ‘Patient Zero’, a
Canadian flight attendant
who travelled extensively
worldwide.
 In the United States, the
rapid spread of AIDS
between 1984 and 1990 can
be modelled accurately
using air traffic flows
between cities.
(CDC, Yellow Book 2012)
DRUG RESISTANCE
 MRSA, Strains of N. gonorrhoeae & multidrug resistant

Acinetobacter
travellers.

baumannii

have been

spread

(Ostroff SM, 2012)

by
Travel of NDM-1
 First detected in patient’s stool

who returned to Sweeden after
hospitalisation in India in Jan
2008.
 A total of 37 isolates with
NDM-1 were recovered from
50 UK patients and 143 from
patients
at
Indian
subcontinent
 Since Aug 2010, it has
worldwide distribution except
in Central and South America.
GLOBAL SPREAD OF NDM (June2012)

Ostroff SM, 2012
DENGUE VOYAGE
 In 2000, Dengue spread to the US

via infected travellers.
60

50
40
30
20
10

0
South East
South
Asia
Central Asia

Central
America

South
America

Caribbean Sub Saharan
Africa

Cases of Dengue among travellers (Leader K, Torresi J et al 2013)
CHIKUNGUNYA FLIGHTS
 Restricted to Africa & Asia

and after the Kenya
outbreak in 2004 it
appeared in islands of
Indian Ocean in 2005 and
then
reached
Indian
Subcontinent in 2006.
 Travellers to India and
Indian visitors then spread
it to Europe, North
America and Australia
having viable vectors.
WEST NILE VIRUS
The West Nile Virus is
believed to reach United
States in 1999 via mosquitoes
that crossed oceans by aircraft
wheel wells.
(CDC Yellow Book 2012)
MASS GATHERINGS (MG)
HAJJ PILIGRIMAGE & DISEASES
Health Requirements
Entry Visa:

for

Yellow Fever-Risk area
Meningococcal Meningitis.

(A,C,Y,W135)
Poliomyelitis-Oral Vaccine.
Seasonal Influenza.
(Weekly Epid. Report, 2013)
Spread of Emerging Diseases
 MERS-CoV-EMC/2012

a novel
Corona virus first reported on
24th Sept, 2012 in Saudi Arabia.
 As on 19th Nov, 2013 157 people
affected
with
66
deaths.
(ProMED Mail)
 ‘Sacrifice Voucher’ can spread
Meat borne Zoonoses.
 Blood Borne Pathogen like
Heaptitis B, C and HIV.
(Balaban V, Ahmed, Q, 2011)
KUMBH MELA
100 million people, 600 km pipes, 92 million litres clean
water/day, 35,000 temporary toilets and 10,000 night soil
sweepers.
( Balsari S, 2013)
SPORTS EVENTS
London Olympic 2012:
 15,000 athletes, 70,000
volunteers,
20,000
journalists
and
10
million spectators.
FIFA World Cup 2010:
South Africa
 32 national teams & 3.2
million spectators
World Cup Cricket, 2007
Caribbean islands:
 16 participating nations
and 1 million spectators.
INTERNATIONAL ORGANISATIONS
FOOD AND WATER PRECAUTIONS
 Bottled water.
 Selection of foods
 well-cooked and hot.

 Avoidance of
 salads, raw vegetables, raw or

undercooked eggs and meat.
 unpasteurized dairy products
 street vendors
 Ice.
30
VECTOR PRECAUTIONS
 Protective Clothing.
 Insect repellent containing DEET 25 – 50%
 Treatment of outer clothing with
permethrin or etofenprox.
 Use of permethrin-impregnated bed net
 Use of insect screens over open windows
 Air conditioned rooms
 Use of aerosol insecticide indoors
 Use of pyrethroid coils outdoors
31
BLOODBORNE DISEASES & STD PRECAUTIONS
Avoid
 Unprotected sexual activity
 Commercial sex workers
 Tattooing and body piercing
 Blood products
 Dental and surgical procedures

32
INTERNATIONAL HEALTH REGULATIONS, 2005
 Came into force on 15th June 2007.

Their main objectives are to ensure:
(1) Routine, preventive measures (e.g. at ports and airports)
and the use by all countries of internationally approved
documents (e.g. vaccination certificates);
(2)The notification to WHO of all events that may constitute
a public health emergency of international concern; and
(3) The implementation of any temporary recommendations
should the WHO Director-General have determined that
such an emergency is occurring.
(International travel & health, 2012)
ANIMAL TRAVEL & DISEASES
Species

Diseases

Bovine

Bovine Spongiform Encephalopathy, CBPP, FMD, BVD.

Equine

Equine Infectious Anaemia, Glanders, Dourine, Equine
Infectious Metritis,
Infectious Equine Abortion,
Piroplasmosis, Equine Influenza, VEE.
(AQ&CS, Govt. Of India)

Caprine & Ovine

Borders Disease, PPR.

Swine

Nipah Viral Encephalitis,
Respiratory Syndrome.

Porcine

Avain

Reproductive

&

HPAI, LPAI, IBD, New Castle Diseases.

•The Livestock Importation Act, 1898.
•The Prevention & Control of Infectious and Contagious
Diseases in Animal Act , 2009
WHAT TO DO?
 Pre-travel Medical Consultation.
 Strengthening of travel industry.
 Redefine responsibility of the travellers.
 Introduction of Travel Health & Mass Gathering Health in

Public Health Curriculum.
 Medical Insurance of travellers.

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Global travel and spread of infections

  • 1. MINOR CREDIT SEMINAR Dr. Adhiraj Mishra, M.V.Sc (1st Year), Div. of Epidemiology Dr. DK Singh, Principal Scientist, Veterinary Public Health Dr. Bhoj R Singh, Principal Scientist and Head, Division of Epidemiology
  • 2. MAGNITUDE OF GLOBAL TRAVEL  International arrivals will reach 1.6 billion by 2020. International Tourist (million) 903 940 2007 2010  Travel to developing countries increased from 31 % to 47% and to Asia Pacific and Middle East have doubled in last decade. (UNWTO-2012) 435 1990
  • 4. REASON OF TRAVEL International Travel & Health, 2012
  • 5. TRAVEL RELATED RISK factors  Mode of transport.  Destination.  Duration and season of travel.  Purpose of travel.  Behaviour of the travellers.  Underlying health of the travellers.
  • 6. AIR TRAVEL & Associated Risks  Quality of Aircraft cabin     air & HEPA Filter. Auxiliary Air Unit. Aircraft Disinsection. Disease transmission: Coughing, sneezing and direct or indirect contact. e.g-TB, Influenza, SARS
  • 7. SEA TRAVEL & Associated Risks  13 million passengers travel worldwide on cruise ship. (UNWTO).  Disease transmission through: Contaminated food & Water, Whirlpool spa, inhalation. e.g. Gastroenteritis (2006), Influenza & other RTI, Legionellosis (1994) (International Travel & Health, 2012)
  • 8. MODES OF DISEASE TRANSMISSION Routes Diseases Food borne & Waterborne Traveller’s diarrhoea, Cholera, Cryptosporidiosis, Giardiaisis, Hepatitis A & E, Listeriosis & Typhoid Fever Air borne TB, SARS, Mumps, diptheria, measles Vector Borne Animal Borne Malaria, Yellow Fever, Dengue, Japanese Encephalitis, Chikungunya & Tick borne encephalitis. Rabies, Brucellosis, Leptospirosis Blood borne Hepatitis B & C, HIV/AIDS and Malaria Sexually Transmitted Hepatitis, HIV/AIDS & Syphilis Soil borne Anthrax, Ascariasis, Trichuris, Fungal infections Recreational Water Leptospira, Pseudomanas, Legionellosis, Schistosoma, CLM, Giardia, Cryptosporidium, Tinea & Cutaneous papilloma.
  • 9. DISEASE DIAGNOSIS BY GEOSENTINEL SITES Diagnosis Cases Malaria 1,762 Giardiasis 1,296 Dengue Fever 888 Campylobacteriosis 596 Cutaneous Larva migrans 577 Rabies P E Prophylaxis 349 Enteric Fever 262 Spotted Fevers 220 Chikungunya 120 Acute Hepatitis A 94 Confirmed Influenza A/B 84 Leader K, Torresi J et al, 2013
  • 10. SEVERE ACUTE RESPIRATORY SYNDROME (SARS)  Zoonotic viral disease caused by the SARS-CoV.  By July 2003, 8,273 cases and 775 deaths reported in multiple countries (9.6% fatality rate). Within weeks, SARS spread from Hong Kong to 37 countries in early 2003. (WHO)  1st seen- Guangdong Province of China-16th Nov, 2002  Dr. Liu Jianlun reached Hong Kong-21st Feb, 2003  Stayed in Metropole Hotel Room No.911 and shifted to Hospital on 22nd Feb 2003 and died on 4th March
  • 11. Contd.  American businessman who stayed in the same hotel, now travelling from China to Singapore had emergency landing in Vietnam and died.  Disease spread to Canada, Singapore, China, Vietnam , United States, Mongolia etc.  WHO issued global alert on 12th March 2003.  1st case in India- 32 year man in Goa, who returned from Hong Kong and Singapore on 17th April 2003.
  • 12. GLOBAL SPREAD OF SARS The WHO Report, 2003
  • 13. PANDEMIC INFLUNZA (H1N1)  “pH1N1", 1st identified in April 2009, and initially spread in Mexico and then globally.  Emerged from pigs in Asia, and was carried to North America by infected persons.  The first case of the Swine flu in India -on 13 May 2009, when a 23 year old man travelling by Emirates Airline from New York to Hyderabad via Dubai.
  • 14. AVIAN INFLUNZA (H5N1)  Avian influenza A (H5N1), first seen in Hong Kong in 1997. Then, it reappeared in Vietnam in 2003 and has been in continuous circulation ever since.  H5N1 has primarily affected poultry, from 2003 through 2011, 578 human illnesses in 15 countries were reported, with an alarming case-fatality ratio of 59%.  The countries with the most cases of human disease (Indonesia, Vietnam, and Egypt) account for 80% of all cases and 78% of all deaths. (Ostroff SM, 2012)
  • 15. AVIAN INFLUENZA IN CHINA  Avian influenza A (H7N9) virus was first reported in China among human beings and poultry.  Till 6th Nov, 2o13, 139 H7N9 human infections were reported & 45 people died. (ProMED-Mail).  Person-to-person spread of H7N9 is rare.
  • 16. PREVENTION OF RESPIRATORY INFECTIONS       Frequent washing of hands with soap & water. Disinfection of household surfaces. Wear disposable gloves and apron and N-95 mask. Eye protection (e.g. face shield or goggles) if splash or spray of body fluids is likely. Thermal Screening at airport & Quarantine. Social distancing.
  • 17. HIV/AIDS and Travel  HIV-I pandemic started by mid 70s and 80s spread to five continents through air travel, sea travel and human migration.  Case of ‘Patient Zero’, a Canadian flight attendant who travelled extensively worldwide.  In the United States, the rapid spread of AIDS between 1984 and 1990 can be modelled accurately using air traffic flows between cities. (CDC, Yellow Book 2012)
  • 18. DRUG RESISTANCE  MRSA, Strains of N. gonorrhoeae & multidrug resistant Acinetobacter travellers. baumannii have been spread (Ostroff SM, 2012) by
  • 19. Travel of NDM-1  First detected in patient’s stool who returned to Sweeden after hospitalisation in India in Jan 2008.  A total of 37 isolates with NDM-1 were recovered from 50 UK patients and 143 from patients at Indian subcontinent  Since Aug 2010, it has worldwide distribution except in Central and South America.
  • 20. GLOBAL SPREAD OF NDM (June2012) Ostroff SM, 2012
  • 21. DENGUE VOYAGE  In 2000, Dengue spread to the US via infected travellers. 60 50 40 30 20 10 0 South East South Asia Central Asia Central America South America Caribbean Sub Saharan Africa Cases of Dengue among travellers (Leader K, Torresi J et al 2013)
  • 22. CHIKUNGUNYA FLIGHTS  Restricted to Africa & Asia and after the Kenya outbreak in 2004 it appeared in islands of Indian Ocean in 2005 and then reached Indian Subcontinent in 2006.  Travellers to India and Indian visitors then spread it to Europe, North America and Australia having viable vectors.
  • 23. WEST NILE VIRUS The West Nile Virus is believed to reach United States in 1999 via mosquitoes that crossed oceans by aircraft wheel wells. (CDC Yellow Book 2012)
  • 25. HAJJ PILIGRIMAGE & DISEASES Health Requirements Entry Visa: for Yellow Fever-Risk area Meningococcal Meningitis. (A,C,Y,W135) Poliomyelitis-Oral Vaccine. Seasonal Influenza. (Weekly Epid. Report, 2013)
  • 26. Spread of Emerging Diseases  MERS-CoV-EMC/2012 a novel Corona virus first reported on 24th Sept, 2012 in Saudi Arabia.  As on 19th Nov, 2013 157 people affected with 66 deaths. (ProMED Mail)  ‘Sacrifice Voucher’ can spread Meat borne Zoonoses.  Blood Borne Pathogen like Heaptitis B, C and HIV. (Balaban V, Ahmed, Q, 2011)
  • 27. KUMBH MELA 100 million people, 600 km pipes, 92 million litres clean water/day, 35,000 temporary toilets and 10,000 night soil sweepers. ( Balsari S, 2013)
  • 28. SPORTS EVENTS London Olympic 2012:  15,000 athletes, 70,000 volunteers, 20,000 journalists and 10 million spectators. FIFA World Cup 2010: South Africa  32 national teams & 3.2 million spectators World Cup Cricket, 2007 Caribbean islands:  16 participating nations and 1 million spectators.
  • 30. FOOD AND WATER PRECAUTIONS  Bottled water.  Selection of foods  well-cooked and hot.  Avoidance of  salads, raw vegetables, raw or undercooked eggs and meat.  unpasteurized dairy products  street vendors  Ice. 30
  • 31. VECTOR PRECAUTIONS  Protective Clothing.  Insect repellent containing DEET 25 – 50%  Treatment of outer clothing with permethrin or etofenprox.  Use of permethrin-impregnated bed net  Use of insect screens over open windows  Air conditioned rooms  Use of aerosol insecticide indoors  Use of pyrethroid coils outdoors 31
  • 32. BLOODBORNE DISEASES & STD PRECAUTIONS Avoid  Unprotected sexual activity  Commercial sex workers  Tattooing and body piercing  Blood products  Dental and surgical procedures 32
  • 33. INTERNATIONAL HEALTH REGULATIONS, 2005  Came into force on 15th June 2007. Their main objectives are to ensure: (1) Routine, preventive measures (e.g. at ports and airports) and the use by all countries of internationally approved documents (e.g. vaccination certificates); (2)The notification to WHO of all events that may constitute a public health emergency of international concern; and (3) The implementation of any temporary recommendations should the WHO Director-General have determined that such an emergency is occurring. (International travel & health, 2012)
  • 34. ANIMAL TRAVEL & DISEASES Species Diseases Bovine Bovine Spongiform Encephalopathy, CBPP, FMD, BVD. Equine Equine Infectious Anaemia, Glanders, Dourine, Equine Infectious Metritis, Infectious Equine Abortion, Piroplasmosis, Equine Influenza, VEE. (AQ&CS, Govt. Of India) Caprine & Ovine Borders Disease, PPR. Swine Nipah Viral Encephalitis, Respiratory Syndrome. Porcine Avain Reproductive & HPAI, LPAI, IBD, New Castle Diseases. •The Livestock Importation Act, 1898. •The Prevention & Control of Infectious and Contagious Diseases in Animal Act , 2009
  • 35. WHAT TO DO?  Pre-travel Medical Consultation.  Strengthening of travel industry.  Redefine responsibility of the travellers.  Introduction of Travel Health & Mass Gathering Health in Public Health Curriculum.  Medical Insurance of travellers.