Cholethiasis refers to the presence of gallstones within the gallbladder or bile ducts. These stones can be composed of cholesterol, bilirubin, or a combination of both, and their formation is often attributed to an imbalance in the components of bile. Factors such as obesity, rapid weight loss, certain medications, and specific medical conditions can contribute to their development. Cholethiasis may lead to symptoms such as intense abdominal pain, nausea, vomiting, and jaundice. Treatment options vary depending on the severity of symptoms and may involve dietary modifications, medication, or, in severe cases, surgical removal of the gallbladder.