1. Drug Delivery System(DDS)
Names Topics
Shafqat Shakeel Introduction to DDS
Aqsa Tariq Types of DDS
Allah Rakhia Components of DDS
Imdad Hussain Advantages
Fardeen khan Challenges and future trends
Ammar yasir Applications
Abdullah Basit Summarize
Mis Anum batool
Biotechnology
7Th morning
To
By
3. Drug Delivery System
What are drug delivery systems?
Drug delivery systems describe technologies that carry drugs into or throughout
the body. These technologies include the
1. method of delivery, such as a pill that you swallow or a
2. vaccine that is injected.
Drug delivery systems can also describe the way that drugs are ‘packaged’—like
a nanoparticle—that protects the drug from degradation and allows it to travel
wherever it needs to go in the body.
4. Drug Delivery System (DDS):
the method or process used to administer pharmaceutical compounds to achieve a
therapeutic effect.
Importance of Efficient Drug Delivery:
1. Targeted drugs formulation
2. Enhanced Therapeutic Efficacy
3. Optimized Drug Bioavailability
4. Innovation in Drug Development
5. Reduce risk of damage to other tissues
5. Types
Conventional DDS
Classical method for delivery of drug into the body
1. Oral
2. Buccal
3. Intravenous
4. Subcutaneous
5. Intramuscular
6. Noval Drug delivery system
A novel drug delivery system is a new approach that utilizes new technologies,
innovative ideas, and methodologies to deliver the active molecules
Modes:
1. Targeted DDS (Targeted Drug Delivery Systems (TDDS) revolutionize medicine by
delivering medications precisely to the intended site of action
2. Sustained DDS (Sustained Drug Delivery Systems, which are designed to release a
therapeutic agent over an extended period, maintaining a consistent concentration
of the drug in the body)
3. Modulated DDS ("Modulated DDS" refers to Modulated Drug Delivery Systems,
which are designed to vary the rate or timing of drug release according to
predetermined patterns or specific needs.)
7.
8. Components of Drug Delivery System
The components of a drug delivery system typically include:
1. Drug Reservoir: This component stores the medication or therapeutic
substance to be delivered.
2. Release Mechanism: It controls the release of the drug from the system,
ensuring it is dispensed at the appropriate rate and duration.
3. Targeting System: This component guides the delivery of the drug to the specific
site within the body where it is needed, minimizing systemic exposure and
maximizing local concentration.
9. 4. Rate Control System: This regulates the rate at which the drug is released,
often ensuring a sustained or controlled release over time.
5. Protective Coatings or Layers: These may be included to protect the drug or
the delivery system from the external environment or to govern the delivery
process.
6. Sensors and Feedback Mechanisms: In some advanced systems, sensors and
feedback mechanisms may be incorporated to monitor drug release and respond
to changes in physiological conditions.
These elements collectively contribute to the efficacy, safety, and controlled
administration of drugs within the body, optimizing therapeutic outcomes.
10. Advantages
Improved Patient Compliance:
Enhanced Therapeutic Efficacy:
targeted delivery systems can increase drug effectiveness.
Reduced Side Effects:
Tailored Drug Release Profiles:
11. Challenges and Future Trends
Challenges in Drug Delivery:
Biological barriers (blood-brain barrier, mucosal barriers).
Stability and shelf-life issues.
Current Research and Innovations:
nanotechnology in drug delivery. Nano robots using as drug carrier
personalized medicine and its potential. Vary person to person
12. Applications
Drug Delivery Systems (DDS) have a wide range of applications across various medical
fields. Here are some notable applications:
Cancer Treatment
- DDS is extensively used in oncology to deliver chemotherapy drugs directly to tumor
sites, minimizing damage to healthy tissues and reducing side effects.
Chronic Disease Management
- For conditions like diabetes, cardiovascular diseases, and autoimmune disorders,
DDS helps in sustained drug release, improving patient adherence and disease
management.
Pain Management
- DDS is employed in pain management to provide sustained release of analgesics,
offering continuous pain relief for chronic conditions.
13. Hormone Replacement Therapy:
- DDS enables controlled release of hormones for hormone replacement therapy,
ensuring a steady and regulated hormonal balance.
Vaccines
- DDS is explored for vaccine delivery to improve immunization strategies,
providing controlled and sustained release for enhanced immune responses.
