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As OuiShare Fest teaser puts it: "communities are transforming cities, organizations and civic action everywhere in the world". As this transformations prove to grow bigger every day, questions about their consequences arise. What are their meaning and direction? What relationships between individuals and corporations do communities allow for? Who governs them and how is value created allocated? More widely, we should now seriously question the new balances being established between empowerment and exploitation.

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Versão Lean da palestra sobre novos modelos de negócios, organizações exponenciais e transformação digital, no Congresso Paraibano de Excelência em Gestão - CONPEG 2015: http://conpeg.com.br/ Gustavo Machado, MS Consultor e Professor de Inovação e Empreendedorismo http://www.ConsultorInovacao.com.br http://www.linkedin.com/in/consultorinovacao/pt gustavo@gustavo-machado.com Skype: Gustavo.Machado40 (19) 99238-3918 "A melhor forma de prever o futuro é desenhá-lo!" - Peter Drucker

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Workshop Design Thinking - Inovação Sempre Presente. Realizado no Instituto Eldorado em Dezembro de 2014. Contato Gustavo Machado, MS Consultor e Professor de Inovação e Empreendedorismo http://www.ConsultorInovacao.com.br http://www.linkedin.com/in/consultorinovacao/pt http://www.gustavo-machado.com/professor gustavo@gustavo-machado.com Skype: Gustavo.Machado40 (19) 99238-3918 DesignEducation.ca - Sharing our Future http://www.designeducation.ca "A melhor forma de prever o futuro é desenhá-lo!" - Peter Drucker

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i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource. This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and Associate Division Director for Ambulatory Operations The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma. STATEMENT OF NEED Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL. Target Audience Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL). Learning Objectives 1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL 2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults 3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection

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