How it occurs: Outside the catheter- Inside the catheter- Urinary Catheter Contamination can occur in two ways, Extraluminal- Insertion of the urinary catheter tip, from organisms on the external urethral meatus Dragging of organisms along the full length of the urethra as the catheter is inserted fully into the bladder Pathogens in the perineum ascending from the catheter to the urethra. Ex. Enterococci , Staphylococci , and Candida species Capillary action in the thin mucous film surrounding the catheter, can lead to BSI Intraluminal- Retrograde reflux of contaminated urine. Moving or manipulating the catheter or collection system. Opening the closed drainage system. The most common organisms associated with CAUTI are Escherichia coli (21.4%), Candida (21%), Enterococcus (14.9%), Pseudomonas aeruginosa (10%), Klebsiella pneumonia (7.7%), and Enterobacter (4.1%). If a biofilm occurs when the catheter is not properly inserted causing damage to the urethra or when catheter care is not performed. This leads to a polysaccharide matrix caused by multiple microorganisms growing on the catheter. Occurs within 18 ° can lead to bladder obstruction, sepsis/ BSI, and/or death. The only way to rid of a biofilm on the catheter is to replace it with a new one.