Mutants Simon Bishop 613545

Mutants Simon Bishop 613545 An organism or cell with a mutation. A mutation is a DNA base pair change or chromosome change. Mutants defective in a biological process can be used to increase our understanding of that process.

Point Mutations Missense mutation Nonsense mutation Neutral mutation Silent mutation Frameshift mutation Fig 19.3 from Essential iGenetics, Russell Mutants can be studied by selecting for known phenotype or genotype .

Model organisms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

1. The Cell Cycle Engine ,[object Object],[object Object],[object Object],[object Object],[object Object],Figure 2 from Nature vol 256 (1975) p549

2. Knockout organisms i ,[object Object],[object Object]

2. Knockout organisms ii Exon Neomycin R Intron Knockout chromosome (vector DNA) Chromosome of ES cell Plate on medium with Neomycin wt

2. Knockout Organisms iii Diagram from Introduction to Genetic Analysis, Gelbart, W et al Parents F1 F2

2. Knockout Organisms iv ,[object Object],[object Object],[object Object],Figure 1a from Nature Genetics vol 31 p385

2. Knockout Organisms v ,[object Object],[object Object],[object Object],[object Object],Figure 4g,h from Nature Genetics vol 31 p385

Summary ,[object Object],[object Object],[object Object],[object Object],[object Object]

Mutants Simon Bishop 613545

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Mutants Simon Bishop 613545