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What s Available for Trans-
            Radial Access
                          Amit Segev, MD, FESC
                        Interventional Cardiology
                       Chaim Sheba Medical Center
Sheba Medical Center
Tel Hashomer                                   The Leviev Heart Center
Anatomy
                         Radial
                         Artery           Ulnar
                                         Artery




                       Palmar
                       Arch




Sheba Medical Center
Tel Hashomer                        The Leviev Heart Center
Allen s test




Sheba Medical Center
Tel Hashomer                          The Leviev Heart Center
Interpretation of Allen s




Sheba Medical Center
Tel Hashomer                             The Leviev Heart Center
Assessment of ulnar arch by
                       oxymetry
  n Allen’s test is subjective and difficult to
     interpret
  n Barbeau score


                                                    2	
  min	
  




Sheba Medical Center   Barbeau.	
  G	
  et	
  al;	
  Am	
  Heart	
  J	
  2004;147:489–93	
  
Tel Hashomer                                                                                   The Leviev Heart Center
Barbeau score




                                                 NO	
  

Sheba Medical Center
                       Barbeau.	
  G	
  et	
  al;	
  Am	
  Heart	
  J	
  2004;147:489–93	
  
Tel Hashomer                                                                            The Leviev Heart Center
Room Setup




Sheba Medical Center
Tel Hashomer                        The Leviev Heart Center
Immobilizing wrist




Sheba Medical Center
Tel Hashomer                            The Leviev Heart Center
Access
                Anatomic Limitations



Sheba Medical Center
Tel Hashomer                     The Leviev Heart Center
RADIAL ACCESS
                          Micro Puncture kit
                          Hydrophilic Sheath




Sheba Medical Center
Tel Hashomer                                   The Leviev Heart Center
Radial Spasm
  n  Prevention
          n Sedation / Nitro / Verapamil
          n Hydrophilic-coated sheath and catheter
  n  Treatment
          n Nitro / sedation / verapamil / Time…



                                    8 minutes
                                      later




Sheba Medical Center
Tel Hashomer                                     The Leviev Heart Center
Terumo Wire




Sheba Medical Center
Tel Hashomer                         The Leviev Heart Center
Anatomic variations
  n  23 % of 2 211 radial procedures
  n  Tortuosity:
                n  3.8 %
                n  98.8 % of success rate of the procedure
  n  Stenotic radial artery
                n  1.7 %
                n  91.9 % of success rate of the procedure
  n  Hypoplastic radial artery
                n  7.7 %
                n  93.9 % success rate
  n  Radio-ulnar loop/radial reccurent artery
                n  0.8 %
                n  83.3 % success rate
            Catheterization and Cardiovascular Interventions 67:870–878 (2006)
Sheba Medical Center
Tel Hashomer                                                            The Leviev Heart Center
Radial/Brachial loop
n Terumo GW
n Coronary 0.014 wire
n Straightened the brachial loop with 4-5-6 F
   catheter
n Long exchange wires




             Catheterization and Cardiovascular Interventions 68:260–262 (2006)
Sheba Medical Center
Tel Hashomer                                                            The Leviev Heart Center
Tortuous Subclavian / Innominate artery

   n  Deep breath to lower the heart
   n  Terumo wire
   n  Coronary wire
   n  Straighten Subclavian by placing stiff wire
   n  Long sheath




Sheba Medical Center
Tel Hashomer                                         The Leviev Heart Center
Understanding the Catheter s Course


    Right Radial        Left Radial     Femoral




          2 points of    1 point of     1 point of
          resistance     resistance     resistance


Sheba Medical Center
Tel Hashomer                          The Leviev Heart Center
TRA: Mechanisms of Failure
     Total number of Failures                             98/2100 (4.6%)

     Failure of arterial access
       Inadequate arterial puncture                                        13%
     Failure to advance catheter to ascending aorta
       Radial artery spasm                                                 34%
                      HYDROPHYLIC SHEATHS NOT USED
       Radial artery dissection                                            10%
       Radial artery loop/tortuosity                                        6%
       Radial artery stenosis                                               1%
     Failure to complete PCI due to lack of guide support
       Subclavian tortuosity                                               18%
       Inadequate guide backup support                                     17%


            n=2,100              Dehghani, P. et al. J Am Coll Cardiol Intv 2009;2:1057-1064

Sheba Medical Center
Tel Hashomer                                                    The Leviev Heart Center
Catheter selection – why
                       Standard femoral Dx catheters may be used as
                           well as several other universal curves


  •  Learning curve
  •  Single vs. Double catheter technique
         –  Judkins: JL3.5 and JR4 or 5 (XB??)
         –  Single catheters:
                •  Jacky, Tiger, Sarah, Kimny, Fajadet
  •  TRA PCI
         –  Right: JR4 or 5 – Left: EBU 3.5 / XB3.0
         –  Single Catheter Technique: Ikari L

Sheba Medical Center
Tel Hashomer                                                          The Leviev Heart Center
Catheter Selection: Femoral vs Radial
           Radial access requires the use of finger-based torque movements instead of 

                             the wrist-based used in femoral access

     •  Catheter Manipulation Technique
            –  Transradial approach can involve more tortuosity than the femoral
               approach
            –  TRA necessitating small (finger-based) clockwise and
               counterclockwise torquing movements and active catheter holding
               as there may be multiple friction points in the subclavian and the
               aorta




                              JL 3.5 Radial                JL 4.0 Femoral
                       Different curve mechanics, 

Sheba Medical Center   sizing and backup support
Tel Hashomer                                                                The Leviev Heart Center
Transradial Curves for Left Coronary –
                          Judkins Left




 Standard curve for the left coronary artery
  (may be particularly useful for short left
            coronary arteries)
            Sizing suggestions:
Downsize the curve by 0.5 from what is used 
   Judkins engagement technique, similar to
          for a femoral approach                femoral approach. Very fine torquing
                                                movements may be required to direct the
                                                catheter toward the left coronary artery

   Sheba Medical Center
   Tel Hashomer                                                       The Leviev Heart Center
Transradial Curves for Left Coronary – Extra Backup




Workhorse curve for left coronary
            artery
          Sizing suggestions:
         JL3.5 = EBU3.5 / XB3
            JL4.0 = EBU3.75
             Comparable to:
          Cordis: XB, XBLAD
   BSC: Muta Left, Radial Curve,
         Brachial Curve

Sheba Medical Center
Tel Hashomer                                      The Leviev Heart Center
Transradial Curves for Left Coronary – EBU/XB




Sheba Medical Center
Tel Hashomer                          The Leviev Heart Center
Single Catheter Solutions
                       for Diagnostic Catheterization

 Terumo s Optitorque
  Diagnostic Catheter
Available in 5F and 6F

                                                                               Amplatz
                                                                               shape tip




                                      Tiger                   Jacky

                           Rarely coaxial, good for   Amplatz type tip (to address
                           RCA, the tip tends to      engagement issues), better
                           point superior             suited for LV




Sheba Medical Center
Tel Hashomer                                                               The Leviev Heart Center
Jacky Catheter: Selective Engagement of
               RCA and LM




Sheba Medical Center
Tel Hashomer                    The Leviev Heart Center
IKARI Left Catheter




Sheba Medical Center
Tel Hashomer                             The Leviev Heart Center
IKARI Catheter vs. Standard Catheters




                              Ikari Y, et. al. Journal of Invasive Cardiology 2005
Sheba Medical Center
Tel Hashomer                                           The Leviev Heart Center
IKARI Left Catheter: Multivessel Intervention




Sheba Medical Center
Tel Hashomer                         The Leviev Heart Center
Transradial Curves for Right Coronary –
                     Judkins Right




Standard curve for right coronary artery
    (may be particularly useful for
           inferior takeoffs)
          Sizing suggestions:
       Same as femoral approach
               Comparable to:              Judkins engagement technique, similar to
                                             femoral approach. Apply a clockwise
           Cordis: Judkins Right            rotation to engage right coronary artery
            BSC: Judkins Right
Sheba Medical Center
Tel Hashomer                                                       The Leviev Heart Center
Transradial Curves for Right Coronary –
                 Judkins Right




                       Deep intubation of RCA with JR4

Sheba Medical Center
Tel Hashomer                                             The Leviev Heart Center
Considerations for Using 5F Guide Catheters



     •  Miniaturization of products allow 5F use
     •  Small radial arteries may not be suited for
        6F guides
     •  Less spasm, less patient discomfort
     •  Lower incidence of radial vessel occlusion
     •  Less contrast/ injection = less nephrotoxicity




Sheba Medical Center
Tel Hashomer                                             The Leviev Heart Center
My Way…
                       Works in >95% of cases
  •  Lidocaine 2% 0.5cc
  •  Dedicated radial sheath: Terumo,
     Cordis 6FR
  •  IA verapamil 2.5 mg
  •  IV heparin 3000-5000U
  •  Diagnostic catheters 5FR– JL3.5 + JR4
  •  Guiding catheters 6FR – XB3.0 or JR4

Sheba Medical Center
Tel Hashomer                               The Leviev Heart Center
Conclusions
     •  Room setup is crucial
     •  Radial puncture – follow rules
            –  Use only dedicated radial kits
     •  NEVER push against even minor resistance
     •  Find the catheter that works best for you – Practice
        makes perfect
     •  Catheter engagement and support represent
        significant barriers to transradial procedural success
            –  Keep the guidewire in the catheter until you cannulate
     •  Knowledge of catheter selection and technique enable
        successful PCI
     •  Complex PCI is achievable with existing equipment
            –  CTO, bifurcations….
     •  TR specific guiding catheters may offer advantages

Sheba Medical Center
Tel Hashomer                                              The Leviev Heart Center

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Segev A

  • 1. What s Available for Trans- Radial Access Amit Segev, MD, FESC Interventional Cardiology Chaim Sheba Medical Center Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 2. Anatomy Radial Artery Ulnar Artery Palmar Arch Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 3. Allen s test Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 4. Interpretation of Allen s Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 5. Assessment of ulnar arch by oxymetry n Allen’s test is subjective and difficult to interpret n Barbeau score 2  min   Sheba Medical Center Barbeau.  G  et  al;  Am  Heart  J  2004;147:489–93   Tel Hashomer The Leviev Heart Center
  • 6. Barbeau score NO   Sheba Medical Center Barbeau.  G  et  al;  Am  Heart  J  2004;147:489–93   Tel Hashomer The Leviev Heart Center
  • 7. Room Setup Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 8. Immobilizing wrist Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 9. Access Anatomic Limitations Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 10. RADIAL ACCESS Micro Puncture kit Hydrophilic Sheath Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 11. Radial Spasm n  Prevention n Sedation / Nitro / Verapamil n Hydrophilic-coated sheath and catheter n  Treatment n Nitro / sedation / verapamil / Time… 8 minutes later Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 12. Terumo Wire Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 13. Anatomic variations n  23 % of 2 211 radial procedures n  Tortuosity: n  3.8 % n  98.8 % of success rate of the procedure n  Stenotic radial artery n  1.7 % n  91.9 % of success rate of the procedure n  Hypoplastic radial artery n  7.7 % n  93.9 % success rate n  Radio-ulnar loop/radial reccurent artery n  0.8 % n  83.3 % success rate Catheterization and Cardiovascular Interventions 67:870–878 (2006) Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 14. Radial/Brachial loop n Terumo GW n Coronary 0.014 wire n Straightened the brachial loop with 4-5-6 F catheter n Long exchange wires Catheterization and Cardiovascular Interventions 68:260–262 (2006) Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 15. Tortuous Subclavian / Innominate artery n  Deep breath to lower the heart n  Terumo wire n  Coronary wire n  Straighten Subclavian by placing stiff wire n  Long sheath Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 16. Understanding the Catheter s Course Right Radial Left Radial Femoral 2 points of 1 point of 1 point of resistance resistance resistance Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 17. TRA: Mechanisms of Failure Total number of Failures 98/2100 (4.6%) Failure of arterial access Inadequate arterial puncture 13% Failure to advance catheter to ascending aorta Radial artery spasm 34% HYDROPHYLIC SHEATHS NOT USED Radial artery dissection 10% Radial artery loop/tortuosity 6% Radial artery stenosis 1% Failure to complete PCI due to lack of guide support Subclavian tortuosity 18% Inadequate guide backup support 17% n=2,100 Dehghani, P. et al. J Am Coll Cardiol Intv 2009;2:1057-1064 Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 18. Catheter selection – why Standard femoral Dx catheters may be used as well as several other universal curves •  Learning curve •  Single vs. Double catheter technique –  Judkins: JL3.5 and JR4 or 5 (XB??) –  Single catheters: •  Jacky, Tiger, Sarah, Kimny, Fajadet •  TRA PCI –  Right: JR4 or 5 – Left: EBU 3.5 / XB3.0 –  Single Catheter Technique: Ikari L Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 19. Catheter Selection: Femoral vs Radial Radial access requires the use of finger-based torque movements instead of 
 the wrist-based used in femoral access •  Catheter Manipulation Technique –  Transradial approach can involve more tortuosity than the femoral approach –  TRA necessitating small (finger-based) clockwise and counterclockwise torquing movements and active catheter holding as there may be multiple friction points in the subclavian and the aorta JL 3.5 Radial JL 4.0 Femoral Different curve mechanics, 
 Sheba Medical Center sizing and backup support Tel Hashomer The Leviev Heart Center
  • 20. Transradial Curves for Left Coronary – Judkins Left Standard curve for the left coronary artery (may be particularly useful for short left coronary arteries) Sizing suggestions: Downsize the curve by 0.5 from what is used 
 Judkins engagement technique, similar to for a femoral approach femoral approach. Very fine torquing movements may be required to direct the catheter toward the left coronary artery Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 21. Transradial Curves for Left Coronary – Extra Backup Workhorse curve for left coronary artery Sizing suggestions: JL3.5 = EBU3.5 / XB3 JL4.0 = EBU3.75 Comparable to: Cordis: XB, XBLAD BSC: Muta Left, Radial Curve, Brachial Curve Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 22. Transradial Curves for Left Coronary – EBU/XB Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 23. Single Catheter Solutions for Diagnostic Catheterization Terumo s Optitorque Diagnostic Catheter Available in 5F and 6F Amplatz shape tip Tiger Jacky Rarely coaxial, good for Amplatz type tip (to address RCA, the tip tends to engagement issues), better point superior suited for LV Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 24. Jacky Catheter: Selective Engagement of RCA and LM Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 25. IKARI Left Catheter Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 26. IKARI Catheter vs. Standard Catheters Ikari Y, et. al. Journal of Invasive Cardiology 2005 Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 27. IKARI Left Catheter: Multivessel Intervention Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 28. Transradial Curves for Right Coronary – Judkins Right Standard curve for right coronary artery (may be particularly useful for inferior takeoffs) Sizing suggestions: Same as femoral approach Comparable to: Judkins engagement technique, similar to femoral approach. Apply a clockwise Cordis: Judkins Right rotation to engage right coronary artery BSC: Judkins Right Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 29. Transradial Curves for Right Coronary – Judkins Right Deep intubation of RCA with JR4 Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 30. Considerations for Using 5F Guide Catheters •  Miniaturization of products allow 5F use •  Small radial arteries may not be suited for 6F guides •  Less spasm, less patient discomfort •  Lower incidence of radial vessel occlusion •  Less contrast/ injection = less nephrotoxicity Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 31. My Way… Works in >95% of cases •  Lidocaine 2% 0.5cc •  Dedicated radial sheath: Terumo, Cordis 6FR •  IA verapamil 2.5 mg •  IV heparin 3000-5000U •  Diagnostic catheters 5FR– JL3.5 + JR4 •  Guiding catheters 6FR – XB3.0 or JR4 Sheba Medical Center Tel Hashomer The Leviev Heart Center
  • 32. Conclusions •  Room setup is crucial •  Radial puncture – follow rules –  Use only dedicated radial kits •  NEVER push against even minor resistance •  Find the catheter that works best for you – Practice makes perfect •  Catheter engagement and support represent significant barriers to transradial procedural success –  Keep the guidewire in the catheter until you cannulate •  Knowledge of catheter selection and technique enable successful PCI •  Complex PCI is achievable with existing equipment –  CTO, bifurcations…. •  TR specific guiding catheters may offer advantages Sheba Medical Center Tel Hashomer The Leviev Heart Center